418 research outputs found
Effects of f(R) Model on the Dynamical Instability of Expansionfree Gravitational Collapse
Dark energy models based on f(R) theory have been extensively studied in
literature to realize the late time acceleration. In this paper, we have chosen
a viable f(R) model and discussed its effects on the dynamical instability of
expansionfree fluid evolution generating a central vacuum cavity. For this
purpose, contracted Bianchi identities are obtained for both the usual matter
as well as dark source. The term dark source is named to the higher order
curvature corrections arising from f(R) gravity. The perturbation scheme is
applied and different terms belonging to Newtonian and post Newtonian regimes
are identified. It is found that instability range of expansionfree fluid on
external boundary as well as on internal vacuum cavity is independent of
adiabatic index but depends upon the density profile, pressure
anisotropy and f(R) model.Comment: 26 pages, no figure. arXiv admin note: text overlap with
arXiv:1108.266
Interference in a Spherical Phase-Space and Asymptotic-Behavior of the Rotation Matrices
We extend the interference in the phase-space algorithm of Wheeler and Schleich [W. P. Schleich and J. A. Wheeler, Nature 326, 574 (1987)] to the case of a compact, spherical topology in order to discuss the large j limits of the angular momentum marginal probability distributions. These distributions are given in terms of the standard rotation matrices. It is shown that the asymptotic distributions are given very simply by areas of overlap in the classical spherical phase-space parametrized by the components of angular momentum. The results indicate the very general validity of the interference in phase-space concept for computing semiclassical limits in quantum mechanics
Patient preferences for the design of a pharmacy-based colorectal cancer screening program
Purpose: To assess preferences for design of a pharmacy-based colorectal cancer (CRC) screening program (PharmFIT™) among screening-eligible adults in the United States (US) and explore the impact of rurality on pharmacy use patterns (e.g., pharmacy type, prescription pick-up preference, service quality rating). Methods: We conducted a national online survey of non-institutionalized US adults through panels managed by Qualtrics, a survey research company. A total of 1,045 adults (response rate 62%) completed the survey between March and April 2021. Sampling quotas matched respondents to the 2010 US Census and oversampled rural residents. We assessed pharmacy use patterns by rurality and design preferences for learning about PharmFIT™; receiving a FIT kit from a pharmacy; and completing and returning the FIT kit. Results: Pharmacy use patterns varied, with some notable differences across rurality. Rural respondents used local, independently owned pharmacies more than non-rural respondents (20.4%, 6.3%, p < 0.001) and rated pharmacy service quality higher than non-rural respondents. Non-rural respondents preferred digital communication to learn about PharmFIT™ (36% vs 47%; p < 0.001) as well as digital FIT counseling (41% vs 49%; p = 0.02) more frequently than rural participants. Preferences for receiving and returning FITs were associated with pharmacy use patterns: respondents who pick up prescriptions in-person preferred to get their FIT (OR 7.7; 5.3–11.2) and return it in-person at the pharmacy (OR 1.7; 1.1–2.4). Conclusion: Pharmacies are highly accessible and could be useful for expanding access to CRC screening services. Local context and pharmacy use patterns should be considered in the design and implementation of PharmFIT™
Decreased occurrence of ketoacidosis and preservation of beta cell function in relatives screened and monitored for type 1 diabetes in Australia and New Zealand
Published December 2022Aims: Islet autoantibody screening of infants and young children in the Northern Hemisphere, together with semi-annual metabolic monitoring, is associated with a lower risk of ketoacidosis (DKA) and improved glucose control after diagnosis of clinical (stage 3) type 1 diabetes (T1D). We aimed to determine if similar benefits applied to older Australians and New Zealanders monitored less rigorously. Methods: DKA occurrence and metabolic control were compared between T1D relatives screened and monitored for T1D and unscreened individuals diagnosed in the general population, ascertained from the Australasian Diabetes Data Network. Results: Between 2005 and 2019, 17,105 relatives (mean (SD) age 15.7 (10.8) years; 52% female) were screened for autoantibodies against insulin, glutamic acid decarboxylase, and insulinoma-associated protein 2. Of these, 652 screened positive to a single and 306 to multiple autoantibody specificities, of whom 201 and 215, respectively, underwent metabolic monitoring. Of 178 relatives diagnosed with stage 3 T1D, 9 (5%) had DKA, 7 of whom had not undertaken metabolic monitoring. The frequency of DKA in the general population was 31%. After correction for age, sex and T1D family history, the frequency of DKA in screened relatives was >80% lower than in the general population. HbA1c and insulin requirements following diagnosis were also lower in screened relatives, consistent with greater beta cell reserve. Conclusions: T1D autoantibody screening and metabolic monitoring of older children and young adults in Australia and New Zealand, by enabling pre-clinical diagnosis when beta cell reserve is greater, confers protection from DKA. These clinical benefits support ongoing efforts to increase screening activity in the region and should facilitate the application of emerging immunotherapies.John M. Wentworth, Helena Oakey, Maria E. Craig, Jennifer J. Couper, Fergus J. Cameron, Elizabeth A. Davis, Antony R. Lafferty, Mark Harris, Benjamin J. Wheeler, Craig Jefferies, Peter G. Colman, Leonard C. Harriso
Individual Confidence-Weighting and Group Decision-Making
Group-living species frequently pool individual information so as to reach consensus decisions such as when and where to move, or whether a predator is present. Such opinion-pooling has been demonstrated empirically, and theoretical models have been proposed to explain why group decisions are more reliable than individual decisions. Behavioural ecology theory frequently assumes that all individuals have equal decision-making abilities, but decision theory relaxes this assumption and has been tested in human groups. We summarise relevant theory and argue for its applicability to collective animal decisions. We consider selective pressure on confidence-weighting in groups of related and unrelated individuals. We also consider which species and behaviours may provide evidence of confidence-weighting, paying particular attention to the sophisticated vocal communication of cooperative breeders
From the Big Bang Theory to the Theory of a Stationary Universe
We consider chaotic inflation in the theories with the effective potentials
phi^n and e^{\alpha\phi}. In such theories inflationary domains containing
sufficiently large and homogeneous scalar field \phi permanently produce new
inflationary domains of a similar type. We show that under certain conditions
this process of the self-reproduction of the Universe can be described by a
stationary distribution of probability, which means that the fraction of the
physical volume of the Universe in a state with given properties (with given
values of fields, with a given density of matter, etc.) does not depend on
time, both at the stage of inflation and after it. This represents a strong
deviation of inflationary cosmology from the standard Big Bang paradigm. We
compare our approach with other approaches to quantum cosmology, and illustrate
some of the general conclusions mentioned above with the results of a computer
simulation of stochastic processes in the inflationary Universe.Comment: No changes to the file, but original figures are included. They
substantially help to understand this paper, as well as eternal inflation in
general, and what is now called the "multiverse" and the "string theory
landscape." High quality figures can be found at
http://www.stanford.edu/~alinde/LLMbigfigs
Stellar structure and compact objects before 1940: Towards relativistic astrophysics
Since the mid-1920s, different strands of research used stars as "physics
laboratories" for investigating the nature of matter under extreme densities
and pressures, impossible to realize on Earth. To trace this process this paper
is following the evolution of the concept of a dense core in stars, which was
important both for an understanding of stellar evolution and as a testing
ground for the fast-evolving field of nuclear physics. In spite of the divide
between physicists and astrophysicists, some key actors working in the
cross-fertilized soil of overlapping but different scientific cultures
formulated models and tentative theories that gradually evolved into more
realistic and structured astrophysical objects. These investigations culminated
in the first contact with general relativity in 1939, when J. Robert
Oppenheimer and his students George Volkoff and Hartland Snyder systematically
applied the theory to the dense core of a collapsing neutron star. This
pioneering application of Einstein's theory to an astrophysical compact object
can be regarded as a milestone in the path eventually leading to the emergence
of relativistic astrophysics in the early 1960s.Comment: 83 pages, 4 figures, submitted to the European Physical Journal
Newtonian and Post Newtonian Expansionfree Fluid Evolution in f(R) Gravity
We consider a collapsing sphere and discuss its evolution under the vanishing
expansion scalar in the framework of gravity. The fluid is assumed to be
locally anisotropic which evolves adiabatically. To study the dynamics of the
collapsing fluid, Newtonian and post Newtonian regimes are taken into account.
The field equations are investigated for a well-known model of the form
admitting Schwarzschild solution. The perturbation scheme is
used on the dynamical equations to explore the instability conditions of
expansionfree fluid evolution. We conclude that instability conditions depend
upon pressure anisotropy, energy density and some constraints arising from this
theory.Comment: 20 pages, accepted for publication in Astrophys. Space Sc
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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