Liquid meal composition, postprandial satiety hormones, and perceived appetite and satiety in obese women during acute caloric restriction

OBJECTIVE: The purpose of this study was to compare postprandial satiety regulating hormone responses (pancreatic polypeptide (PP) and peptide tyrosine tyrosine (PYY)) and visual analog scale- (VAS) assessed perceived appetite and satiety between liquid high-protein (HP) and high-carbohydrate (HC) meals in obese women during acute (24-h) caloric restriction. DESIGN: Eleven obese premenopausal women completed two conditions in random order in which they consumed 1500 calories as six 250-calorie HP meals or six 250-calorie HC meals over a 12-h period. Blood samples were taken at baseline and every 20 min thereafter and analyzed for PP and PYY concentrations. At these same points, perceived hunger and fullness were assessed with a VAS. The incremental area under the curve (iAUC) was used to compare postprandial responses. RESULTS: THE 12-H PP AND PYY IAUC WERE GREATER (P0.05) DURING THE HP CONDITION (PP: 4727±1306 pg/ml×12 h, PYY: 1373±357 pg/ml×12 h) compared with the HC condition (PP: 2300±528 pg/ml×12 h, PYY: 754±246 pg/ml×12 h). Perceived hunger and fullness were not different between conditions (P>0.05). The greatest changes in PYY and perceived fullness occurred after the morning meals during both conditions. CONCLUSIONS: These data suggest that in obese women during acute caloric restriction before weight loss, i) liquid HP meals, compared with HC meals, result in greater postprandial PP and PYY concentrations, an effect not associated with differential appetite or satiety responses, and ii) meal-induced changes in PYY and satiety are greatest during the morning period, regardless of dietary macronutrient composition

Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function.

BACKGROUND: Anemia is associated with decreased functional capacity, reduced quality of life, and worsened outcomes among patients with heart failure (HF) due to reduced left ventricular ejection fraction (HFREF). We sought to evaluate the independent effect of anemia on clinical outcomes among those with HFREF. HYPOTHESIS: Anemia is associated with cardiovascular events in patients with heart failure. METHODS: The HF-ACTION trial was a prospective, randomized trial of exercise therapy vs usual care in 2331 patients with HFREF. Patients with New York Heart Association class II to IV HF and left ventricular ejection fractions of ≤ 35% were recruited. Hemoglobin (Hb) was measured up to 1 year prior to entry and was stratified by quintile. Anemia was defined as baseline Hb/dL and/dL in men and women, respectively. Hemoglobin was assessed in 2 models: a global prediction model that had been previously developed, and a modified model including variables associated with anemia and the studied outcomes. RESULTS: Hemoglobin was available at baseline in 1763 subjects (76% of total study population); their median age was 59.0 years, 73% were male, and 62% were Caucasian. The prevalence of anemia was 515/1763 (29%). Older age, female sex, African American race, diabetes, hypertension, and lower estimated glomerular filtration rates were all more frequent in lower Hb quintiles. Over a median follow-up of 30 months, the primary outcome of all-cause mortality or all-cause hospitalization occurred in 78% of those with anemia and 64% in those without (P \u3c 0.001). The secondary outcomes of all-cause mortality alone,cardiovascular (CV) mortality or CV hospitalization, and CV mortality or HF hospitalization occurred in 23% vs 15%, 67% vs 54%, and 44 vs 29%, respectively (P \u3c 0.001). Heart failure hospitalizations occurred in 36% vs 22%, and urgent outpatient visits for HF exacerbations occurred in 67% and 55%, respectively (P \u3c 0.001). For the global model, there was an association observed for anemia and all-cause mortality or hospitalization (adjusted hazard ratio [HR]: 1.15, 95% confidence interval [CI]: 1.01-1.32, P = 0.04), but other outcomes were not significant at P \u3c 0.05. In the modified model, the adjusted HR for anemia and the primary outcome of all-cause mortality or all-cause hospitalization was 1.25 (95% CI: 1.10-1.42, P \u3c 0.001). There were independent associations between anemia and all-cause death (HR: 1.11, 95% CI: 0.87-1.42, P = 0.38), CV death or CV hospitalization (HR: 1.16, 95% CI: 1.01-1.33, P = 0.035), and CV death and HF hospitalization (HR: 1.27, 95% CI: 1.06-1.51, P = 0.008). CONCLUSIONS: Anemia modestly is associated with increased rates of death, hospitalization, and HF exacerbation in patients with chronic HFREF. After adjusting for other important covariates, anemia is independently associated with an excess hazard for all-cause mortality and all-cause hospitalization. Anemia is also associated with combinations of CV death and CV/HF hospitalizations as composite endpoints

Nebivolol, a beta adrenergic receptor antagonist blocks angiotensin II-mediated signaling in heart [abstract]

We recently showed that Nebivolol, a [beta]-adrenergic receptor (AR) antagonist attenuates myocardial oxidative stress and promotes insulin metabolic signaling in 9 week old Zucker obese (ZO) insulin resistant rats. Here, we demonstrate that Nebivolol suppresses angiotensin II type I receptor (AT1R)-mediated signaling in ZO hearts as well as in HL-1 cardiomyocytes

Using Peer Mentors to screen for CKD at dialysis units: Targeting high‐risk family members

OBJECTIVE The incidence of chronic kidney disease (CKD) is increasing and affects one in nine individuals in the United States. Genetics and lifestyle factors contribute to the incidence of CKD and serve as screening targets. We screened for predisposition to CKD at dialysis units in southeast Michigan, where obesity and hypertension are common. Families of dialysis patients, as well as non‐relatives and staff, were evaluated. Peer Mentors with CKD participated in the screening. METHODS “Prevention Fairs” utilized inexpensive screening to determine a predisposition to CKD: urine dipstick for protein, glucose, or blood; BP > 140/90; and body mass index (BMI) > 30. Peer Mentor participation, honoring long‐standing patients, and invitations to state legislators were included. RESULTS “Fairs” at 16 Michigan centers screened 497 individuals: 61% (305) had one finding, 18% (88) had two, and 6% (29) had three. Obesity was most common (220), and then hypertension (169), proteinuria (41), glycosuria (15), and hematuria (13). Although we had hypothesized that the highest risk would be found among genetic family members, positive screening was not statistically different between genetic relatives and other individuals. In addition, findings were distributed equally across varied demographic settings and races, underscoring the importance of social determinants of health. DISCUSSION Genetic factors are hypothesized to be predictors for CKD, but these results suggest that CKD risk may also be related to social determinants such as diet, exercise, health consciousness, socioeconomics, or cultural acceptance of obesity. Screening at dialysis centers, enhanced by participation of peers and social activities, contributes to referral for further treatment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86849/1/20582_ftp.pd

The Ursinus Weekly, April 12, 1973

Board of Control meets, elects John Fidler editor; New staff chosen for Fall • J-Board plans complete; Meat boycott discussed • Alpha Phi Omega plans • Ecological concern cites collection days • IR Club to go to NY • Meistersingers return; Complete successful tour • Travelin\u27 6 concert to be held May 3 • Editorial: Taking care of business; Bury the faith at Wounded Knee • Faculty portrait: Dr. J.C. Noman Miller • Student spotlight • Film review: The Poseidon Adventure • Letter to the editor: Beef about beef • Thinclads wallop F&M; Sing sets mark • Netmen drop opener • Diamond season in full swing • Lacrosse team is successful at Sanford • Doreen Rhoads competes at intercollegiateshttps://digitalcommons.ursinus.edu/weekly/1102/thumbnail.jp

The Ursinus Weekly, January 12, 1973

SFARC investigates campus issues • Six Ursinus professors named outstanding educators of America • Final exam schedule • Graduate sub-committee submits investigative study • Editorial: Shifting off of the back burner • Focus: Sarah Sellers • Much ado about something different • Letter to the editor • Grapplers take home opener • Erratic Bears split pair • Three Ursinus ladies on U.S. hockey squadhttps://digitalcommons.ursinus.edu/weekly/1095/thumbnail.jp

The Ursinus Weekly, December 14, 1972

Chemotherapist speaks to Pre-med group • Messiah performance successful • Union Board of Governors holds organizing meeting • Special convocation grants degree • Board of Control meets to select Weekly editors • Ursinus Judo Club jumps into action • Editorial: Life; Victim of a third class system • In retrospect: The Fantasticks is musical for everyone • Fidler on the wax: Zappa, The Grand Wazoo • The Bear Squad • Bear hoopsters drop pair • Grapplers open season • W. A. A. sponsors activity clinic • Non-skid floor rough on ankles! • Water wonders workout daily • U.C. hosts polo clinichttps://digitalcommons.ursinus.edu/weekly/1094/thumbnail.jp

The Ursinus Weekly, May 10, 1973

USGA meets, discusses possible demerit change • Shakespeare\u27s Shrew tames Thompson-Gay gym tonight • Randy Cole, a sophomore, will study in Scotland next year • Buddhis Follies perform at Valley Forge hospital • IRC, representing India, takes third place in N.Y. • Editorial: The Food at Ursinus • Travelin\u27 6 show is a success due to variety of acts and talent • A memorial to the skipped diploma; A salute to the Good Humor man • Current events series presents wiretap lecture • Musical organizations at U.C. in review; Credit hours given • Tennis enters intercollegiates; Lacrosse places 12 in trials • Sports buffs\u27 corner • Ursinus beats Haverford in baseball, 9-2; Bears 5 & 6 • Letters to the sports editors: Seniors are, for the most part, still alive and well; Who\u27s dying out ?https://digitalcommons.ursinus.edu/weekly/1104/thumbnail.jp

Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)

BACKGROUND: The relationship between glycemic control and lipid abnormalities with urinary albumin-creatinine ratio (ACR) in chronic kidney disease (CKD) patients with diabetes mellitus (DM) is unknown. We sought to investigate the association of dyslipidemia and glycemic control with levels of albuminuria in the National Kidney Foundation (NKF) Kidney Early Evaluation Program (KEEP) participants with DM and CKD stage 3 or higher. METHODS: We performed a cross-sectional study of 6639 eligible KEEP patients with DM and CKD Stage 3 to 5 from June 2008 to December 2009. Multivariate logistic regression was used to evaluate the association of lipid parameters (per 10 mg/dl change in serum level) and glycosylated hemoglobin (HbA1c) values with three degrees of albuminuria normo (<30 mg⁄g), micro (30 to 300 mg⁄g) and macro (>300 mg⁄g). RESULTS: 2141 KEEP participants were included. HbA1c levels were strongly associated with micro-albuminuria (compared to normo-albuminuria) and macro-albuminuria (compared to normo-albuminuria and micro-albuminuria). Each 1.0% increase in HbA1c increased the odds of micro-albuminuria by 32% (OR 1.32, 95% CI 1.23-1.42) and the odds of macro-albuminuria (vs. microalbuminuria) by 16% (OR 1.16, 95% CI 1.05-1.28). Only increases in serum HDL were associated with decreased odds of micro-albuminuria; otherwise, the association between other components of the serum lipid profile with urinary ACR did not reach statistical significance. CONCLUSION: In this cross-sectional study of 2141 KEEP participants with DM and CKD stages 3–5, overall glycemic control but not lipids were associated with abnormal urinary albumin excretion, a marker of increased risk for progressive disease

The Ursinus Weekly, December 7, 1972

Ursinus Board of Directors meets; Acts on degree policy, appointments • Dr. E. H. Miller elected vice president of Northeast Political Science Association • Eleven U.C. students named to Who\u27s who • Dr. James Craft presents paper to Northeast group • Editorial: A little secret; Start suggesting stories! • Faculty portrait: Peter Forrest Small • The Case of the missing counselor • Student Union group outlines plans for Spring, \u2773 opening • Yearbook staff to present campus life realistically • Letters to the editor • Messiah performance to be thirty fifth at U.C. • Dr. Carl F. Henry, theologian, speaks at college forum • Cagers open with victory; Late rally nips Fords • U.C. hockey players off to California • Sig Rho whips Beta Sig in Ursinus football classichttps://digitalcommons.ursinus.edu/weekly/1093/thumbnail.jp