The age of white dwarf companions

Original paper can be found at: http://www.iop.org/EJ/conf DOI: 10.1088/1742-6596/172/1/012019 [16th European White Dwarfs Workshop]We carried out a spectroscopic investigation of single lined white dwarfs (WDs) in double degenerate (DD) systems and discuss their binary evolution. Simulated spectra of the Hα region are used to derive upper limits on the temperature of the invisible component and thus lower limits on the cooling age. This is done for a range of hypothetical secondary masses and a minimum cooling age deduced. Results are compared with the well known parameters of the visible primary, which allows us to determine a lower limit for the cooling age difference of both WDs. Most of the ten systems in our sample have a minimum age difference of not larger than 0.5 Gyr and their small orbital separation is highly suggestive of at least one unstable mass transfer phase. However, a stable first mass transfer phase is feasible as the age difference is less then 1 Gyr. The results imply that unstable mass transfer is the most likely final contact binary scenario to have occurred in DD systems but the first mass transfer phase is not constrained.Peer reviewe

Contributory Negligence in Product Liability

This article does not purport to be exhaustive. It does explore the extent to which classical defenses of contributory negligence, assumption of risk and their relative, misuse of product, are available in product liability actions. Caveat: By the time this printer\u27s ink is drysome of these applications may be available no longer

Group B streptococcal infection and activation of human astrocytes.

BACKGROUND:Streptococcus agalactiae (Group B Streptococcus, GBS) is the leading cause of life-threatening meningitis in human newborns in industrialized countries. Meningitis results from neonatal infection that occurs when GBS leaves the bloodstream (bacteremia), crosses the blood-brain barrier (BBB), and enters the central nervous system (CNS), where the bacteria contact the meninges. Although GBS is known to invade the BBB, subsequent interaction with astrocytes that physically associate with brain endothelium has not been well studied. METHODOLOGY/PRINCIPAL FINDINGS:We hypothesize that human astrocytes play a unique role in GBS infection and contribute to the development of meningitis. To address this, we used a well- characterized human fetal astrocyte cell line, SVG-A, and examined GBS infection in vitro. We observed that all GBS strains of representative clinically dominant serotypes (Ia, Ib, III, and V) were able to adhere to and invade astrocytes. Cellular invasion was dependent on host actin cytoskeleton rearrangements, and was specific to GBS as Streptococcus gordonii failed to enter astrocytes. Analysis of isogenic mutant GBS strains deficient in various cell surface organelles showed that anchored LTA, serine-rich repeat protein (Srr1) and fibronectin binding (SfbA) proteins all contribute to host cell internalization. Wild-type GBS also displayed an ability to persist and survive within an intracellular compartment for at least 12 h following invasion. Moreover, GBS infection resulted in increased astrocyte transcription of interleukin (IL)-1β, IL-6 and VEGF. CONCLUSIONS/SIGNIFICANCE:This study has further characterized the interaction of GBS with human astrocytes, and has identified the importance of specific virulence factors in these interactions. Understanding the role of astrocytes during GBS infection will provide important information regarding BBB disruption and the development of neonatal meningitis

Appeasement of Tort Claimants

Justice does not always mean that a case should be tried. By the same token, justice does not always mean that every case should be settled without trial. One of our difficulties is that too often there is more interest in the expedient settlement of differences between litigants than in a judicial determination of rights according to principles of law

Increased human pathogenic potential of Escherichia coli from polymicrobial urinary tract infections in comparison to isolates from monomicrobial culture samples

The current diagnostic standard procedure outlined by the Health Protection Agency for urinary tract infections (UTIs) in clinical laboratories does not report bacteria isolated from samples containing three or more different bacterial species. As a result many UTIs go unreported and untreated, particularly in elderly patients, where polymicrobial UTI samples are especially prevalent. This study reports the presence of the major uropathogenic species in mixed culture urine samples from elderly patients, and of resistance to front-line antibiotics, with potentially increased levels of resistance to ciprofloxacin and trimethoprim. Most importantly, the study highlights that Escherichia coli present in polymicrobial UTI samples are statistically more invasive (P<0.001) in in vitro epithelial cell infection assays than those isolated from monomicrobial culture samples. In summary, the results of this study suggest that the current diagnostic standard procedure for polymicrobial UTI samples needs to be reassessed, and that E. coli present in polymicrobial UTI samples may pose an increased risk to human health

A Modified Fock Function for the Distribution of Currents in the Penumbra Region With Discontinuity in Curvature

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116088/1/rds1966191045.pd

The impact of the AuScope VLBI observations and the regional AUSTRAL sessions on the TRF

The AuScope VLBI array was built with the purpose to improve the terrestrial (TRF) and celestial reference frames in the southern hemisphere. Since 2010 the three 12-m antennas in Hobart (Tasmania), Katherine (Northern Territory) and Yarragadee (Western Australia) heavily contribute to the global VLBI observations coordinated by the International VLBI Service for Geodesy and Astrometry. In 2011, the AUSTRAL VLBI program was started, with more than 40 sessions being observed so far. In the AUSTRALs, the three AuScope antennas observe together with the new 15-m dish in Hartebeesthoek (South Africa) and the 12-m antenna in Warkworth (New Zealand). Recently, the planned observations have been expanded again, with 50 additional sessions scheduled until mid-2015, along with 3 continuous campaigns covering 15 days each. All AUSTRALs are recorded with an increased data rate of 1 Gbps, allowing to compensate for the reduced sensitivity of the generally smaller dish size. We evaluate the positive impact of the AuScope VLBI program on the global TRF. This is due to the increased number of observations and the improved homogeneity of the global VLBI network. All data collected within this intense observing program is analysed and geodetic results are presented. This includes time series of baseline lengths and station coordinates of the contributing stations. We compare the results obtained within the regional AUSTRAL sessions with the ones of the classical global VLBI networks and identify superiorities and shortcomings of both. The high number of sessions gives high accuracies and good repeatabilities of the determined parameters. Additionally, remaining variations of baseline lengths can be identified and are compared against by default un-modelled station motions due to hydrology and atmosphere loading. Finally, we give an outlook on future plans for the AuScope antennas and the AUSTRAL observing program: on future operations, expected improvements through hardware upgrades as well as research on the use of sibling telescopes available at two sites within the AUSTRAL array (Hobart and Hartebeesthoek)