54 research outputs found

    Final LDRD report : science-based solutions to achieve high-performance deep-UV laser diodes.

    Get PDF
    We present the results of a three year LDRD project that has focused on overcoming major materials roadblocks to achieving AlGaN-based deep-UV laser diodes. We describe our growth approach to achieving AlGaN templates with greater than ten times reduction of threading dislocations which resulted in greater than seven times enhancement of AlGaN quantum well photoluminescence and 15 times increase in electroluminescence from LED test structures. We describe the application of deep-level optical spectroscopy to AlGaN epilayers to quantify deep level energies and densities and further correlate defect properties with AlGaN luminescence efficiency. We further review our development of p-type short period superlattice structures as an approach to mitigate the high acceptor activation energies in AlGaN alloys. Finally, we describe our laser diode fabrication process, highlighting the development of highly vertical and smooth etched laser facets, as well as characterization of resulting laser heterostructures

    Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

    Get PDF
    Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

    Why is Enceladus' surface so radar-bright?

    No full text
    International audienceThe recent Cassini RADAR Enceladus E16 data reveal a tectonically-complex surface near the South Pole, including areas of different apparent backscatter characteristics. These appear to be tectonically-delimited, implying that the backscatter intensity is the result of either tectonic resurfacing or surface maturity. Previous studies using Earth-based and distant Cassini observations (Ostro et al., 2006, Icarus 183, 479-490, and references within) revealed that many icy satellites, particularly the most active, exhibit unusually low emissivity and high albedo at and near Ku-band (2.17 cm). However, the extreme nature of Enceladus' brightest surfaces are difficult to account for, and appear to be the most intensely backscattering non-specular surfaces in the solar system: up to ~6 dB sigma0 at 48-57 deg incidence angle. We have developed a 2-dimensional finite element model (Khankhoje et al., 2012, IGARSS) of Ku-band radar interactions with ice in order to explore what surface configurations could produce the observed backscatter, including large ice crystals, fracture planes and liquid films formed, under geologically plausible thermochemical conditions. Different structures and mechanisms that could produce the brightness will then be considered in the context of Enceladus' evolution, with due consideration given to whether these same factors could also apply on other icy worlds. Our preliminary results show that rough surfaces are insufficient. We speculate after Ostro et al. (2006) that these surfaces are the result of coherent backscatter from geologically immature surfaces, resulting in a phenomenon similar to cats eyes. The precise structures and their forming mechanisms (space weathering, deposition, or thermal or mechanical modification) are not yet understood, but several types of organized structure in the 10s of cms range are being considered: (1) quasi-spherical surface scatterers cobbles and small bounders, already observed at 10s of metres scales by the Imaging Science System; (2) complex but regular fractures; and (3) unusually large monocrystals. We will continue to investigate these, whittling them down by a process of deduction

    Bibliographie

    No full text

    Crimes de guerre des soci�t�s: Condamner le pillage des ressources naturelles (Corporate War Crimes: Prosecuting Pillage of Natural Resources)

    No full text

    Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications

    No full text
    corecore