Spin depolarization in the transport of holes across GaMnAs/GaAlAs/p-GaAs

We study the spin polarization of tunneling holes injected from ferromagnetic GaMnAs into a p-doped semiconductor through a tunneling barrier. We obtain an upper limit to the spin injection rate. We find that spin-orbit interaction interaction in the barrier and in the drain limits severely spin injection. Spin depolarization is stronger when the magnetization is parallel to the current than when is perpendicular to it.Comment: Accepted in Phys. Rev. B. 4 pages, 4 figure

Abnormal Fetal Growth:Small for Gestational Age, Fetal Growth Restriction, Large for Gestational Age: Definitions and Epidemiology

Abnormal fetal growth (growth restriction and overgrowth) is associated with perinatal morbidity, mortality, and lifelong risks to health. To describe abnormal growth, "small for gestational age" and "large for gestational age" are commonly used terms. However, both are statistical definitions of fetal size below or above a certain threshold related to a reference population, rather than referring to an abnormal condition. Fetuses can be constitutionally small or large and thus healthy, whereas fetuses with seemingly normal size can be growth restricted or overgrown. Although golden standards to detect abnormal growth are lacking, understanding of both pathologic conditions has improved significantly.</p

A multiverse analysis of early attempts to replicate memory suppression with the Think/No-think Task

In 2001, Anderson and Green [2001. Suppressing unwanted memories by executive control. Nature, 410(6826), 366-369] showed memory suppression using a novel Think/No-think (TNT) task. When participants attempted to prevent studied words from entering awareness, they reported fewer of those words than baseline words in subsequent cued recall (i.e., suppression effect). The TNT literature contains predominantly positive findings and few null-results. Therefore we report unpublished replications conducted in the 2000s (N = 49; N = 36). As the features of the data obtained with the TNT task call for a variety of plausible solutions, we report parallel "universes" of data-analyses (i.e., multiverse analysis) testing the suppression effect. Two published studies (Wessel et al., 2005. Dissociation and memory suppression: A comparison of high and low dissociative individuals' performance on the Think-No think Task. Personality and Individual Differences, 39(8), 1461-1470, N = 68; Wessel et al., 2010. Cognitive control and suppression of memories of an emotional film. Journal of Behavior Therapy and Experimental Psychiatry, 41(2), 83-89. https://doi.org/10.1016/j.jbtep.2009.10.005, N = 80) were reanalysed in a similar fashion. For recall probed with studied cues (Same Probes, SP), some tests (sample 3) or all (samples 2 and 4) showed statistically significant suppression effects, whereas in sample 1, only one test showed significance. Recall probed with novel cues (Independent Probes, IP) predominantly rendered non-significant results. The absence of statistically significant IP suppression effects raises problems for inhibition theory and its implication that repression is a viable mechanism of forgetting. The pre-registration, materials, data, and code are publicly available (https://osf.io/qgcy5/).</p

Recurrence Plot Based Measures of Complexity and its Application to Heart Rate Variability Data

The knowledge of transitions between regular, laminar or chaotic behavior is essential to understand the underlying mechanisms behind complex systems. While several linear approaches are often insufficient to describe such processes, there are several nonlinear methods which however require rather long time observations. To overcome these difficulties, we propose measures of complexity based on vertical structures in recurrence plots and apply them to the logistic map as well as to heart rate variability data. For the logistic map these measures enable us not only to detect transitions between chaotic and periodic states, but also to identify laminar states, i.e. chaos-chaos transitions. The traditional recurrence quantification analysis fails to detect the latter transitions. Applying our new measures to the heart rate variability data, we are able to detect and quantify the laminar phases before a life-threatening cardiac arrhythmia occurs thereby facilitating a prediction of such an event. Our findings could be of importance for the therapy of malignant cardiac arrhythmias

Defining the natural history of rare genetic liver diseases:Lessons learned from the NAPPED initiative

While rare diseases collectively affect similar to 300 million people worldwide, the prevalence of each disease concerns a relatively small number of patients. Usually, only limited data with regard to natural history are available. Multicenter initiatives are needed to aggregate data and answer clinically relevant research questions. In 2017, we launched the NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) consortium. In three years, NAPPED created a global network focused on rare genetic liver diseases in the Progressive Familial Intrahepatic Cholestasis (PFIC) spectrum. During these years, we have learned important lessons which we feel should be taken into account when initiating and leading a global consortium.First, it is essential to 'keep it simple' from the start. Research questions, case report forms (CRFs) and data acquisition should be limited and clear to stay focused and keep the workload low for new participants. Secondly, early rewards and research output are needed to keep momentum and motivation. Quick output can only follow a clean and simple design. Thirdly, the leading team should be in touch and accessible. Ideally, an involved PhD-candidate is appointed as primary contact person. Lastly, be inclusive and actively involve all participants the consortium's course.Global consortia are critical for personalized medicine in rare diseases. Also, they are essential for setting up trials to investigate generic drugs and personalized therapies. We hope to herewith stimulate others that are starting (or are planning to start) a global consortium, ultimately to help improve the care for patients with a rare disease.</p

High yield fusion in a Staged Z-pinch

We simulate fusion in a Z-pinch; where the load is a xenon-plasma liner imploding onto a deuterium-tritium plasma target and the driver is a 2 MJ, 17 MA, 95 ns risetime pulser. The implosion system is modeled using the dynamic, 2-1/2 D, radiation-MHD code, MACH2. During implosion a shock forms in the Xe liner, transporting current and energy radially inward. After collision with the DT, a secondary shock forms pre-heating the DT to several hundred eV. Adiabatic compression leads subsequently to a fusion burn, as the target is surrounded by a flux-compressed, intense, azimuthal-magnetic field. The intense-magnetic field confines fusion $\alpha$-particles, providing an additional source of ion heating that leads to target ignition. The target remains stable up to the time of ignition. Predictions are for a neutron yield of $3.0\times 10^{19}$ and a thermonuclear energy of 84 MJ, that is, 42 times greater than the initial, capacitor-stored energy

Moving the needle: Directed intervention by the American Society for Surgery of the Hand is effective in encouraging diversity in expert panel composition

PURPOSE: Recent efforts have been made by the American Society for Surgery of the Hand to encourage female inclusion in expert panels. We hypothesized that female representation on expert panels has increased over the past decade and that a directed intervention by the American Society for Surgery of the Hand would be associated with an increased percentage of submissions with female panelists. METHODS: We performed a retrospective analysis of Instructional Course Lecture and Symposium submissions for the 2011 through 2021 American Society for Surgery of the Hand Annual Meetings. Authorship was reviewed, and the gender of the proposed authors was recorded. Additionally, the status of all-male panel was attributed to panels with no proposed female authors. Submissions were reviewed and compared with meeting programs to determine the status of accepted or rejected. Longitudinal analysis was performed to determine trends in the gender composition of expert panels. RESULTS: In total, 1,687 submissions were reviewed, including 1,323 Instructional Course Lectures and 364 Symposia. Female authorship constituted 18% of authorship (1,170/6,663), and lead authorship was similarly distributed, with 18% being female (296/1,687). Overall, female representation has increased steadily over the past decade, with females constituting 13% (43/332) and 20% (163/818) of the submitted authors in 2011 and 2020, respectively. Similarly, all-male panels declined from 74% (76/103) to 46% (85/185) of panels over the same timeframe. Most strikingly, a sharp increase in gender representation was observed with the directed intervention noted in the 2021 Call for Abstracts, resulting in an increase in female authorship to 26% (295/1,124) and a decline in all-male panels to 29% (70/241). CONCLUSIONS: Gender representation among hand surgery expert panels moved toward increased equity over the past decade, which has been aided by directed interventions. CLINICAL RELEVANCE: Career development and trainee decision making are impacted by gender representation; directed and intentional interventions by professional organizations are effective in encouraging greater equity and diversity within the field