Community Partnerships: An Innovative Model of Social Work Education and Practice

Community challenges force human service agencies to collaborate in providing services. Such collaborations require practitioners to have skills not found in mainstream social work curricula. This paper explores how a new MSW program evolved through dialog with community leaders and resulted in a curriculum with a sole concentration of community partnerships

Computing Storyline Visualizations with Few Block Crossings

Storyline visualizations show the structure of a story, by depicting the interactions of the characters over time. Each character is represented by an x-monotone curve from left to right, and a meeting is represented by having the curves of the participating characters run close together for some time. There have been various approaches to drawing storyline visualizations in an automated way. In order to keep the visual complexity low, rather than minimizing pairwise crossings of curves, we count block crossings, that is, pairs of intersecting bundles of lines. Partly inspired by the ILP-based approach of Gronemann et al. [GD 2016] for minimizing the number of pairwise crossings, we model the problem as a satisfiability problem (since the straightforward ILP formulation becomes more complicated and harder to solve). Having restricted ourselves to a decision problem, we can apply powerful SAT solvers to find optimal drawings in reasonable time. We compare this SAT-based approach with two exact algorithms for block crossing minimization, using both the benchmark instances of Gronemann et al. and random instances. We show that the SAT approach is suitable for real-world instances and identify cases where the other algorithms are preferable.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

Una checklist per la gestione dei costi nel trattamento dell’HIV

The human immunodeficiency virus (HIV) infection is currently one of the major health problems in the world. Since the first occurrence of the infection 17 years ago until today, many people have died of its devastating consequences and an enormous amount of health-related funds have been spent on the problem. The pandemic is still growing in some areas, and its negative impact on society is in-creasing. This is the main reason why scientists are trying to find the best way to reduce costs and still keep the same level of management or, in some ways, even improve it (e.g., new combination of drugs in one pill—fewer pills to be taken per day). Since HIV infection has been. a fatal, severe, and widespread disease, a so-called global problem, very early in the course of the pandemic the idea of economic evaluation was raised. Published studies mostly presented the antiretroviral drugs in the frames of pharmacoeconomic models or costs of HIV/AIDS according to development of the disease through longer time periods. The cost sections that have to be considered in any pharmacoeconomic study of HIV management are briefly presented. Often the presented costs are confusing and could be misleading. Direct, indirect, and intangible costs are described

A Spitzer IRAC Imaging Survey for T Dwarf Companions Around M, L, and T Dwarfs: Observations, Results, and Monte Carlo Population Analyses

We report observational techniques, results, and Monte Carlo population analyses from a Spitzer Infrared Array Camera imaging survey for substellar companions to 117 nearby M, L, and T dwarf systems (median distance of 10 pc, mass range of 0.6 to \sim0.05 M\odot). The two-epoch survey achieves typical detection sensitivities to substellar companions of [4.5 {\mu}m] \leq 17.2 mag for angular separations between about 7" and 165". Based on common proper motion analysis, we find no evidence for new substellar companions. Using Monte Carlo orbital simulations (assuming random inclination, random eccentricity, and random longitude of pericenter), we conclude that the observational sensitivities translate to an ability to detect 600-1100K brown dwarf companions at semimajor axes greater than ~35 AU, and to detect 500-600K companions at semimajor axes greater than ~60 AU. The simulations also estimate a 600-1100K T dwarf companion fraction of < 3.4% for 35-1200 AU separations, and < 12.4% for the 500-600K companions, for 60-1000 AU separations.Comment: 35 pages, 6 figure

Generation of folk song melodies using Bayes transforms

The paper introduces the `Bayes transform', a mathematical procedure for putting data into a hierarchical representation. Applicable to any type of data, the procedure yields interesting results when applied to sequences. In this case, the representation obtained implicitly models the repetition hierarchy of the source. There are then natural applications to music. Derivation of Bayes transforms can be the means of determining the repetition hierarchy of note sequences (melodies) in an empirical and domain-general way. The paper investigates application of this approach to Folk Song, examining the results that can be obtained by treating such transforms as generative models

Suppression of Superconducting Critical Current Density by Small Flux Jumps in MgB2MgB_2 Thin Films

By doing magnetization measurements during magnetic field sweeps on thin films of the new superconductor $MgB_2$, it is found that in a low temperature and low field region small flux jumps are taking place. This effect strongly suppresses the central magnetization peak leading to reduced nominal superconducting critical current density at low temperatures. A borderline for this effect to occur is determined on the field-temperature (H-T) phase diagram. It is suggested that the small size of the flux jumps in films is due to the higher density of small defects and the relatively easy thermal diffusion in thin films in comparison with bulk samples.Comment: 7 figures Phys. Rev. B accepted scheduled issue: 01 Feb 200

Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction

Mammalian sperm are unable to fertilize the egg immediately after ejaculation; they acquire this capacity during migration in the female reproductive tract. This maturational process is called capacitation and in mouse sperm it involves a plasma membrane reorganization, extensive changes in the state of protein phosphorylation, increases in intracellular pH (pHi) and Ca2+ ([Ca2+]i), and the appearance of hyperactivated motility. In addition, mouse sperm capacitation is associated with the hyperpolarization of the cell membrane potential. However, the functional role of this process is not known. In this work, to dissect the role of this membrane potential change, hyperpolarization was induced in noncapacitated sperm using either the ENaC inhibitor amiloride, the CFTR agonist genistein or the K+ ionophore valinomycin. In this experimental setting, other capacitation-associated processes such as activation of a cAMP-dependent pathway and the consequent increase in protein tyrosine phosphorylation were not observed. However, hyperpolarization was sufficient to prepare sperm for the acrosome reaction induced either by depolarization with high K+ or by addition of solubilized zona pellucida (sZP). Moreover, K+ and sZP were also able to increase [Ca2+]i in non-capacitated sperm treated with these hyperpolarizing agents but not in untreated cells. On the other hand, in conditions that support capacitation-associated processes blocking hyperpolarization by adding valinomycin and increasing K+ concentrations inhibited the agonist-induced acrosome reaction as well as the increase in [Ca2+]i. Altogether, these results suggest that sperm hyperpolarization by itself is key to enabling mice sperm to undergo the acrosome reaction.Fil: de La Vega Beltrán, José Luis. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: Sánchez Cárdenas, Claudia. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Hernández González, Enrique. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados; MéxicoFil: Wertheimer Hermitte, Eva Victoria. University of Massachussets; Estados UnidosFil: Trevinio, Claudia L.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: Visconti, Pablo E.. University of Massachussets; Estados UnidosFil: Darszon, Alberto. Universidad Nacional Autónoma de México. Instituto de Biotecnología; Méxic

Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance?

The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacist’s roles and responsibilities have become more clinic and patient focused. In the community (primary care), pharmacists have become important providers of healthcare as Western healthcare policy advocates patient self-care. This has resulted in pharmacists taking on greater responsibility in managing minor illness and the delivery of public health interventions. These roles require pharmacists to more fully use their clinical skills, and often involve diagnosis and therapeutic management. Community pharmacists are now, more than ever before, in a position to identify, record and report medication safety incidents. However, current research suggests that diagnostic ability of community pharmacists is questionable and they infrequently report to local or national schemes. The aim of this paper is to highlight current practice and suggest ways in which community pharmacy can more fully contribute to patient safety