One Step Forward, One Step Back: Shale Gas in Denmark and Sweden

Denmark and Sweden take two-fold positions on the question whether shale gas should be developed. At first sight, it appears the governments are supportive by licencing exploration to domestic and foreign companies. However, Denmark has suspended issuance of new licenses as doubts of extraction activities have risen. Sweden was forced to give landowners and municipalities a say in decision-making, and there is a larger context of mining minerals policy controversy. Even though both countries only have exploration activities at the moment, and the economic promise is yet unclear, public awareness and attention are increasing and cause difficulties for governments and industry to proceed without open discussions and debates. Scandinavia’s green image is at stake as the new fossil fuel opportunities are in conflict with the ambitious goals for renewable energy development. Both countries now have to prioritise energy self-sufficiency and industrial economics versus ecological consciousness

Relating the Cost of Spinning Silk to the Tendency to Share It for Three Embiids with Different Lifestyles (Order Embiidina: Clothodidae, Notoligotomidae, and Australembiidae)

Although adult female embiids (Order Embiidina) superficially lack morphological diversity, their variety of habitats may impose distinct selective pressures on behavior, such as their use of silk and their tendency to aggregate. For example, where silk serves as a primary defense from environmental threats, coloniality might be adaptive. The cost of production or spinning might also prompt them to share silk. These ideas were tested in laboratory trials involving three species of embiids with different lifestyles: an arboreal species (Antipaluria urichi (Saussure) from a neotropical rain forest, a species (Notoligotoma hardyi (Frederichs) that dwells on surfaces of granite outcrops in Australia, and another Australian species (Australembia incompta Ross) that stitches leaf litter together. The cost of spinning silk was analyzed by recording CO2 output in the short term during spinning and by measuring performance in long-term trials where embiids were forced to repeatedly replace their silk. Their subsequent development or reproductive output was scored. Overall, the cost of spinning was relatively low. However, the tendencies to spin and to aggregate varied in a manner related to how silk is used in the field. As such, the more exposed the embiid is to the elements, as for the two species that spin on surfaces, the more silk they spun and the more likely they settled near a neighbor. In contrast, the embiid that used dead leaves (not silk) as walls for their abodes produced scant silk and showed little tendency to aggregate

CSR in the Textile Sector: European Fashion Firms and the Bangladesh Safety Accord

The textile industry has long been criticized for irresponsible and dangerous labour conditions in its global supply chain, particularly in very poor Asian countries like Bangladesh. The April 2013 collapse of the Rana Plaza building in Bangladesh came to be a catalyst for reaching an agreement with international labour unions: the Bangladesh Safety Accord was created. This article analyses the Accord, the involvement of European fashion companies such as Primark, H&M and Inditex, the connection with Corporate Social Responsibility (CSR) programmes, and the outlook for improved industry standards in manufacturing clothing

The Effect of Corporate Governance toward Dividend Payout Ratio

Pupose: The existence of market uncertainty can increase agency problems that raise doubts about future cash flows, such as dividend payments. This study aims to analyze the effect of corporate governance such as the proportion of female commissioners, the proportion of female independent commissioners, the board size, board independence, board meeting, and audit committee size towards a dividend payout ratio. Method:The sample of this research is manufacturing sector companies listed on the Indonesia Stock Exchange (ISE) and the Thailand Stock Exchange (TSE). The company should have published financial reports that have been audited regularly during the study period, and the company has no negative retained earnings. This study uses a quantitative approach with two least square regression analysis models. Result: The observations on the ISE shows that the proportion of female independent commissioners and audit committee size has a significant positive effect on the dividend payout ratio. This result is because female commissioners can take control of minority shareholders by making larger payments and audit committee members can monitor more effectively and control opportunistic behavior. However, board independence and board meeting significantly adversely affect the dividend payout ratio, this is because more members of board independence and more frequent meetings can use dividends as a substitute role in reducing agency problems so that dividend payment will be below. The observations on the TSE shows that the proportion of female independent commissioners and board meetings significantly positively affects the dividend payout ratio. However, board independence has a significant adverse effect on the dividend payout ratio. This result is because board independence tends to reduce agency costs, so using dividends as a substitute role to reduce dividend payments

Angular Distribution of Prompt Photons Using the Compact Muon Solenoid Detector at √S =7 TeV

The study of the angular distribution of photon plus jet events in pp collisions at √S =7 TeV with the Compact Muon Solenoid (CMS) detector is presented. The photon is restricted to the central region of the detector (|η| \u3c 1.4442) while the jet is allowed to be present in both central and forward regions of CMS |η| \u3c 2.4). Dominant backgrounds due to jets fragmenting into neutral mesons are accounted for through the use of a template method that discriminates between signal and background. The angular distribution, |η*|, is defined as the absolute value of the difference in η between the leading photon and leading jet in an event divided by two. The angular distribution ranging from 0-1.4 was examined and compared with next-to-leading order QCD predictions and was found to be in good agreement

Herbal remedies affecting coagulation : a review

CONTEXT: Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade. OBJECTIVE: The compiling of plants investigated for effects on the coagulation cascade. METHODS: Information was withdrawn from Google Scholar and the journal databases Scopus and PubMed. RESULTS: Sixty-five herbal remedies ware identified with antiplatelet, anticoagulant or coagulating ability. Bioactive compounds included polyphenols, taxanes, coumarins, saponins, fucoidans, and polysaccharides. CONCLUSION: Although research has been conducted on the effect of herbal remedies on coagulation, most information relies on in vitro assays. Contradictory evidence is present on bleeding risks with herbal uses, though herb-drug interactions pose a threat. As the safety of many herbals has not been proven, nor their effect on blood parameters determined, the use of herbal preparations before undergoing any surgical procedure should rather be ceased.http://www.tandf.co.uk/journals/titles/13880209.as

The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release. The Drosophila member of this protein family contains three conserved domains (A, C, and E) and is expressed in most or all synaptic terminals. Similar to mouse mutants, synapsin knock-out flies show no obvious structural defects but are disturbed in complex behaviour, notably learning and memory. RESULTS: We demonstrate that the N-terminal phosphorylation consensus motif RRxS that is conserved in all synapsins investigated so far, is modified in Drosophila by pre-mRNA editing. In mammals this motif represents the target site P1 of protein kinase A (PKA) and calcium/calmodulin dependent protein kinase I/IV. The result of this editing, by which RRFS is modified to RGFS, can be observed in cDNAs of larvae and adults and in both isolated heads and bodies. It is also seen in several newly collected wild-type strains and thus does not represent an adaptation to laboratory culture conditions. A likely editing site complementary sequence is found in a downstream intron indicating that the synapsin pre-mRNA can form a double-stranded RNA structure that is required for editing by the adenosine deaminase acting on RNA (ADAR) enzyme. A deletion in the Drosophila Adar gene generated by transposon remobilization prevents this modification, proving that the ADAR enzyme is responsible for the pre-mRNA editing described here. We also provide evidence for a likely function of synapsin editing in Drosophila. The N-terminal synapsin undeca-peptide containing the genomic motif (RRFS) represents an excellent substrate for in-vitro phosphorylation by bovine PKA while the edited peptide (RGFS) is not significantly phosphorylated. Thus pre-mRNA editing by ADAR could modulate the function of ubiquitously expressed synapsin in a cell-specific manner during development and adulthood. CONCLUSION: Similar to several other neuronal proteins of Drosophila, synapsin is modified by ADAR-mediated recoding at the pre-mRNA level. This editing likely reduces or abolishes synapsin phosphorylation by PKA. Since synapsin in Drosophila is required for various forms of behavioural plasticity, it will be fascinating to investigate the effect of this recoding on learning and memory.Published versio

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and Pglycoprotein inhibition

Abstract: Background: Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess the in vitro anticancer and P-glycoprotein inhibitory potential of extracts of S. aculeastrum fruits. Furthermore, assessment of the combinational effect with doxorubicin was also done. Methods: The crude extract was prepared by ultrasonic maceration. Liquid-liquid extraction yielded one aqueous and two organic fractions. Bioactive constituents were isolated from the aqueous fraction by means of column chromatography, solid phase extraction and preparative thin-layer chromatography. Confirmation of bioactive constituent identity was done by nuclear magnetic resonance and ultra-performance liquid chromatography mass spectrometry. The crude extract and fractions were assessed for cytotoxicity and P-glycoprotein inhibition in both cancerous and non-cancerous cell lines using the sulforhodamine B and rhodamine-123 assays, respectively. Results: Both the crude extract and aqueous fraction was cytotoxic to all cell lines, with the SH-SY5Y neuroblastoma cell line being most susceptible to exposure (IC50 = 10.72 μg/mL [crude], 17.21 μg/mL [aqueous]). Dose-dependent P-glycoprotein inhibition was observed for the crude extract (5.9 to 18.9-fold at 100 μg/mL) and aqueous fraction (2.9 to 21.2 at 100 μg/mL). The steroidal alkaloids solamargine and solanine were identified. While solanine was not bioactive, solamargine displayed an IC50 of 15.62 μg/mL, and 9.1-fold P-glycoprotein inhibition at 100 μg/mL against the SH-SY5Y cell line. Additive effects were noted for combinations of doxorubicin against the SH-SY5Y cell line. Conclusions: The crude extract and aqueous fraction displayed potent non-selective cytotoxicity and noteworthy P-glycoprotein inhibition. These effects were attributed to solamargine. P-glycoprotein inhibitory activity was only present at concentrations higher than those inducing cytotoxicity, and thus does not appear to be the likely mechanism for the enhancement of doxorubicin’s cytotoxicity. Preliminary results suggest that non-selective cytotoxicity may hinder drug development, however, further assessment of the mode of cell death is necessary to determine the route forward

One Step Forward, One Step Back: Shale Gas in Denmark and Sweden

Denmark and Sweden take two-fold positions on the question whether shale gas should be developed. At first sight, it appears the governments are supportive by licencing exploration to domestic and foreign companies. However, Denmark has suspended issuance of new licenses as doubts of extraction activities have risen. Sweden was forced to give landowners and municipalities a say in decision-making, and there is a larger context of mining minerals policy controversy. Even though both countries only have exploration activities at the moment, and the economic promise is yet unclear, public awareness and attention are in-creasing and cause difficulties for governments and industry to proceed without open discussions and debates. Scandinavia’s green image is at stake as the new fossil fuel opportunities are in conflict with the ambitious goals for renewable energy development. Both countries now have to prioritise energy self-sufficiency and industrial economics versus ecological consciousness.Keywords: Denmark, energy, energy policy, fracking, hydraulic fracturing, mining, protest, public acceptance, regulatory politics, Scandinavia, shale gas, Sweden, unconventional ga