Gender Differences in Bereavement among Couples after Loss of a Child: A Professionals Perspective

This qualitative study examined gender differences in bereavement, particularly among couples after the loss of a child. Data were collected through semi-standardized interviews with four helping professionals that work with couples during the bereavement process following the death of a child. Common themes were found through an open coding method that analyzed the data for commonalities among the participants. There were four different themes that emerged from the data: reactions and coping mechanisms, family structure, external influences and effect on the marriage. The majority of the findings from this study coincided with previous research. Implications for this study suggest further research into the similarities and differences of bereavement that couples experience after the loss of a child. Further research will only strengthen the understanding of gender differences in bereavement and couples, and professionals can utilize that knowledge throughout the bereavement process

Gender Differences in Bereavement among Couples after Loss of a Child: A Professionals Perspective

This qualitative study examined gender differences in bereavement, particularly among couples after the loss of a child. Data were collected through semi-standardized interviews with four helping professionals that work with couples during the bereavement process following the death of a child. Common themes were found through an open coding method that analyzed the data for commonalities among the participants. There were four different themes that emerged from the data: reactions and coping mechanisms, family structure, external influences and effect on the marriage. The majority of the findings from this study coincided with previous research. Implications for this study suggest further research into the similarities and differences of bereavement that couples experience after the loss of a child. Further research will only strengthen the understanding of gender differences in bereavement and couples, and professionals can utilize that knowledge throughout the bereavement process

Searching the ideal inhaled vasodilator: From nitric oxide to prostacyclin

Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians. The flood of scientific work focussing on this new therapeutic concept had been initiated by a fundamental new observation by Pepke-Zaba {[}1] and Frostell in 1991 {[}2]: Both scientists reported, that inhalation of exogenous nitric oxide (NO) gas selectively dilates pulmonary vessels without a concomittant systemic vasodilation. No more than another decade ago NO was identified as an important endogenous vasodilator {[}3] while having merely been regarded an environmental pollutant before that time. Although inhaled NO proved to be efficacious, alternatives were sought-after due to NO's potential side-effects. In search for the ideal inhaled vasodilator another group of endogenous mediators - the prostanoids - came into the focus of interest. The evidence for safety and efficacy of inhaled prostanoids is - among a lot of other valuable work - based on a series of experimental and clinical investigations that have been performed or designed at the Institute for Surgical Research under the guidance and mentorship of Prof. Dr. med. Dr. h.c. mult. K. Messmer {[}4-19]. In the following, the current and newly emerging clinical applications of inhaled prostanoids and the experimental data which they are based on, will be reviewed. Copyright (C) 2002 S. Karger AG, Basel

The role of microtubule movement in bidirectional organelle transport

We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions. Multiple peroxisomes move in unison over large time windows and show correlations with microtubule tip positions, indicating rapid microtubule fluctuations in the longitudinal direction. We report the first high-resolution measurement of longitudinal microtubule fluctuations performed by tracing such pairs of co-moving peroxisomes. The resulting picture shows that motor-dependent longitudinal microtubule oscillations contribute significantly to cargo movement along microtubules. Thus, contrary to the conventional view, organelle transport cannot be described solely in terms of cargo movement along stationary microtubule tracks, but instead includes a strong contribution from the movement of the tracks.Comment: 24 pages, 5 figure

Inhaliertes PGI2 versus inhaliertes NO bei hypoxisch pulmonaler Vasokonstriktion

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Structural Insights into the Methane-Generating Enzyme from a Methoxydotrophic Methanogen Reveal a Restrained Gallery of Post-Translational Modifications

Methanogenic archaea operate an ancient, if not primordial, metabolic pathway that releases methane as an end-product. This last step is orchestrated by the methyl-coenzyme M reductase (MCR), which uses a nickel-containing F430-cofactor as the catalyst. MCR astounds the scientific world by its unique reaction chemistry, its numerous post-translational modifications, and its importance in biotechnology not only for production but also for capturing the greenhouse gas methane. In this report, we investigated MCR natively isolated from Methermicoccus shengliensis. This methanogen was isolated from a high-temperature oil reservoir and has recently been shown to convert lignin and coal derivatives into methane through a process called methoxydotrophic methanogenesis. A methoxydotrophic culture was obtained by growing M. shengliensis with 3,4,5-trimethoxybenzoate as the main carbon and energy source. Under these conditions, MCR represents more than 12% of the total protein content. The native MCR structure refined at a resolution of 1.6-Å precisely depicts the organization of a dimer of heterotrimers. Despite subtle surface remodeling and complete conservation of its active site with other homologues, MCR from the thermophile M. shengliensis contains the most limited number of post-translational modifications reported so far, questioning their physiological relevance in other relatives

Kinderanästhesie zur Protonenbestrahlung: Medizin fernab der Klinik

Zusammenfassung: Die Betreuung von Kleinkindern für die Protonentherapie stellt fachlich und menschlich hohe Anforderungen an das Anästhesieteam. Das Anästhesiepersonal soll in Kinderanästhesie speziell ausgebildet und erfahren sein, insbesondere da die Kinder sich oft in einem reduzierten Allgemeinzustand befinden. Die Infrastruktur soll gemäß den aktuellen anästhesiologischen Standards eingerichtet sein. Die ständige visuelle Überwachung des sedierten Patienten und das lückenlose Monitoring der Vitaldaten müssen gewährleistet sein. Propofol eignet sich ideal für die Sedierung von Kleinkindern in Spontanatmung für die Protonentherapie. Auch bei repetitiver Gabe über mehrere Wochen wird Propofol sehr gut toleriert. Eine enge Zusammenarbeit zwischen Radioonkologe, Onkologe und Anästhesist ist notwendig, um interkurrent auftretende medizinische Probleme optimal zu behandeln. Die besonderen Belange onkologischer Patienten müssen bei der Therapieplanung berücksichtigt werde