As participações e a evocação de memórias olfativas na produção da artista Josely Carvalho

A presente pesquisa reflete sobre os modos de participação e evocação de memórias que ocorrem em trabalhos da artista brasileira Josely Carvalho, em especial, as instalações: Nidus Vitreo (2010), Vidro de Cheiro (2011) e Diário de cheiros: passagens (2011). Para abordarmos a produção da artista, estruturamos a pesquisa em três etapas, sendo a primeira: a apresentação de um panorama da história da arte por meio de um recorte que demonstre as modificações do campo, da figura do espectador, dos modos de apreensão de um trabalho e o surgimento de participações que envolvem os diversos sentidos do corpo e trazem para a experiência o repertório pessoal do participante. No segundo momento, abordamos o tema memória, seus significados, a sua ligação com o olfato e sua presença na arte. Por fim, iniciamos a abordagem da produção de Josely Carvalho que em sua extensa produção, iniciada na década de 70 nos Estados Unidos, discutiu sobre diversos temas, tais como guerras, a figura da mulher, a ideia de abrigo, dentre outros. Diante de uma escassez de estudos em relação à produção de Josely Carvalho, recorremos ao levantamento de materiais, como entrevistas, catálogos, o que tornou possível verificar a gradativa aparição do odor, da incorporação do repertório pessoal do público e da participação na carreira da artista. Os nexos existentes em sua produção, e apresentados nesta dissertação, nos revelam como a memória olfativa passou a se tornar tema principal em uma série da artista: Diary of Smells. Por meio de uma investigação, verificamos que o convite à participação se une às memórias olfativas do público, ocorrendo de formas distintas, tanto pela forma em que essas memórias são evocadas, por meio do ato consciente de rememorar ou pelo contato com um odor, e incorporadas, pela artista ou pelo próprio público, quanto pelas participações que ora ocorrem no processo de elaboração de instalações, ora no período em que uma instalação é exposta. PALAVRAS-CHAVE: Josely Carvalho; Participação; Memória Olfativa; Odor; Instalação.CAPE

Evaluating The Ecological Sustainability Of Production Networks – A Data-based Approach

The design of global production networks influences the ecological sustainability of manufacturing operations, since it determines the environment with which a production process interacts. Historically sustainability has not been a primary goal for the design of production networks and its evaluation remains a challenge. The multiple goals of sustainability and complex structures of production networks constitute to a high modelling effort that can only be managed with databased solutions. To further decrease the modelling expenditures, the data used in such a solution should be already available or easy to obtain. This paper presents a methodology and data framework to evaluate various ecological sustainability goals, which are impacted by the design of global production networks. The approach is validated with a company that produces electrical appliances

O uso de atividades lúdicas como ferramenta motivadora para o ensino da Tabela Periódica na Educação de Jovens e Adultos.

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Revisiting the use of remission criteria for rheumatoid arthritis by excluding patient global assessment: an individual meta-analysis of 5792 patients

Objectives: To determine the impact of excluding patient global assessment (PGA) from the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) Boolean remission criteria, on prediction of radiographic and functional outcome of rheumatoid arthritis (RA). Methods: Meta-analyses using individual patient data from randomised controlled trials testing the efficacy of biological agents on radiographic and functional outcomes at ≥2 years. Remission states were defined by 4 variants of the ACR/EULAR Boolean definition: (i) tender and swollen 28-joint counts (TJC28/SJC28), C reactive protein (CRP, mg/dL) and PGA (0–10=worst) all ≤1 (4V-remission); (ii) the same, except PGA >1 (4V-near-remission); (iii) 3V-remission (i and ii combined; similar to 4V, but without PGA); (iv) non-remission (TJC28 >1 and/or SJC28 >1 and/or CRP >1). The most stringent class achieved at 6 or 12 months was considered. Good radiographic (GRO) and functional outcome (GFO) were defined as no worsening (ie, change in modified total Sharp score (ΔmTSS) ≤0.5 units and ≤0.0 Health Assessment Questionnaire–Disability Index points, respectively, during the second year). The pooled probabilities of GRO and GFO for the different definitions of remission were estimated and compared. Results: Individual patient data (n=5792) from 11 trials were analysed. 4V-remission was achieved by 23% of patients and 4V-near-remission by 19%. The probability of GRO in the 4V-near-remission group was numerically, but non-significantly, lower than that in the 4V-remission (78 vs 81%) and significantly higher than that for non-remission (72%; difference=6%, 95% CI 2% to 10%). Applying 3V-remission could have prevented therapy escalation in 19% of all participants, at the cost of an additional 6.1%, 4.0% and 0.7% of patients having ΔmTSS >0.0, >0.5 and >5 units over 2 years, respectively. The probability of GFO (assessed in 8 trials) in 4V-near-remission (67%, 95% CI 63% to 71%) was significantly lower than in 4V-remission (78%, 74% to 81%) and similar to non-remission (69%, 66% to 72%). Conclusion: 4V-near-remission and 3V-remission have similar validity as the original 4V-remission definition in predicting GRO, despite expected worse prediction of GFO, while potentially reducing the risk of overtreatment. This supports further exploration of 3V-remission as the target for immunosuppressive therapy complemented by patient-oriented targets

Numerical Implementation of the QuEST Function

This paper deals with certain estimation problems involving the covariance matrix in large dimensions. Due to the breakdown of finite-dimensional asymptotic theory when the dimension is not negligible with respect to the sample size, it is necessary to resort to an alternative framework known as large-dimensional asymptotics. Recently, Ledoit and Wolf (2015) have proposed an estimator of the eigenvalues of the population covariance matrix that is consistent according to a mean-square criterion under large-dimensional asymptotics. It requires numerical inversion of a multivariate nonrandom function which they call the QuEST function. The present paper explains how to numerically implement the QuEST function in practice through a series of six successive steps. It also provides an algorithm to compute the Jacobian analytically, which is necessary for numerical inversion by a nonlinear optimizer. Monte Carlo simulations document the effectiveness of the code.Comment: 35 pages, 8 figure

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases : a systematic review

Background and aims: Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC). Biliary drainage is frequently performed to relieve symptoms of jaundice or enable palliative systemic therapy, but effective drainage can be difficult to accomplish. The aim of this study is to summarize literature on clinical outcomes of biliary drainage in mCRC patients with malignant biliary obstruction.& nbsp; Methods: We searched Medline and EMBASE for studies that included patients with malignant biliary obstruction secondary to mCRC, treated with endoscopic and/or percutaneous biliary drainage. We summarized available data on technical success, clinical success, adverse events, systemic therapy administration and survival after biliary drainage.& nbsp; Results: After screening 3584 references and assessing 509 full-text articles, seven cohort studies were included. In these studies, rates of technical success, clinical success and adverse events varied between 63%-94%, 42%81%, and 19%-39%, respectively. Subsequent chemotherapy was administered in 17%-56% of patients. Overall survival varied between 40 and 122 days across studies (278-365 days in patients who received subsequent chemotherapy, 42-61 days in patients who did not).& nbsp; Conclusions: Successful biliary drainage in mCRC patients can be challenging to achieve and is frequently associated with adverse events. Overall survival after biliary drainage is limited, but is significantly longer in patients treated with subsequent systemic therapy. Expected benefits of biliary drainage should be carefully weighed against its risks