6,971 research outputs found

    Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses

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    Virus infections are known to induce a transient state of immune suppression often associated with an inhibition of T cell proliferation in response to mitogen or cognate-antigen stimulation. Recently, virus-induced immune suppression has been linked to responses to type 1 interferon (IFN), a signal 3 cytokine that normally can augment the proliferation and differentiation of T cells exposed to antigen (signal 1) and co-stimulation (signal 2). However, pre-exposure of CD8 T cells to IFN-inducers such as viruses or poly(IratioC) prior to antigen signaling is inhibitory, indicating that the timing of IFN exposure is of essence. We show here that CD8 T cells pretreated with poly(IratioC) down-regulated the IFN receptor, up-regulated suppressor of cytokine signaling 1 (SOCS1), and were refractory to IFNbeta-induced signal transducers and activators of transcription (STAT) phosphorylation. When exposed to a viral infection, these CD8 T cells behaved more like 2-signal than 3-signal T cells, showing defects in short lived effector cell differentiation, reduced effector function, delayed cell division, and reduced levels of survival proteins. This suggests that IFN-pretreated CD8 T cells are unable to receive the positive effects that type 1 IFN provides as a signal 3 cytokine when delivered later in the signaling process. This desensitization mechanism may partially explain why vaccines function poorly in virus-infected individuals

    Calculating the shear angle in orthogonal metal cutting from fundamental stress-strain-strain rate properties of the work material

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    An analysis of the orthogonal metal cutting process is made which enables the shear angle to be calculated from certain fundamental properties of the work material and the specified cutting conditions. Shear angles are calculated for a range of cutting conditions and good agreement is shown between theory and experiment. In particular, such trends as the decrease in shear angle with decrease in cutting speed and the tendency for the chip to become discontinuous at slow cutting speeds which are found experimentally and cannot be explained in terms of previous shear angle analyses, are shown to be consistent with the present analysis

    Preliminary report on the analysis of the stresses in a die-bolster combination

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    An analysis is presented of the stresses in a carbide die-steel bolster combination. Results from a computer treatment of this analysis are given in tabular and graphical form. Suggestions are made as to the choice of interface diameters, and a nomogram is drawn enabling the maximum allowable interference to be selected

    High ions towards white dwarfs: circumstellar line shifts and stellar temperature

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    Based on a compilation of OVI, CIV, SiIV and NV data from IUE, FUSE, GHRS, STIS, and COS, we derive an anti- correlation between the stellar temperature and the high ion velocity shift w.r.t. to the photosphere, with positive (resp. negative) velocity shifts for the cooler (resp. hotter) white dwarfs. This trend probably reflects more than a single process, however such a dependence on the WD's temperature again favors a CS origin for a very large fraction of those ion absorptions, previously observed with IUE, HST-STIS, HST-GHRS, FUSE, and now COS, selecting objects for which absorption line radial velocities, stellar effective temperature and photospheric velocity can be found in the literature. Interestingly, and gas in near-equilibrium in the star vicinity. It is also probably significant that the temperature that corresponds to a null radial velocity, i.e. \simeq 50,000K, also corresponds to the threshold below which there is a dichotomy between pure or heavy elements atmospheres as well as some temperature estimates for and a form of balance between radiation pressure and gravitation. This is consistent with ubiquitous evaporation of orbiting dusty material. Together with the fact that the fraction of stars with (red-or blue-) shifted lines and the fraction of stars known to possess heavy species in their atmosphere are of the same order, such a velocity-temperature relationship is consistent with quasi-continuous evaporation of orbiting CS dusty material, followed by accretion and settling down in the photosphere. In view of these results, ion measurements close to the photospheric or the IS velocity should be interpreted with caution, especially for stars at intermediate temperatures. While tracing CS gas, they may be erroneously attributed to photospheric material or to the ISM, explaining the difficulty of finding a coherent pattern of the high ions in the local IS 3D distribution.Comment: Accepted by A&A. Body of paper identical to v1. This submission has a more appropriate truncation of the original abstrac

    Comment on ``Validity of certain soft-photon amplitudes''

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    The criteria suggested by Welsh and Fearing (nucl-th/9606040) to judge the validity of certain soft-photon amplitudes are examined. We comment on aspects of their analysis which lead to incorrect conclusions about published amplitudes and point out important criteria which were omitted from their analysis.Comment: 6 pages plus 1 postscript figure, Revte

    Computing a Knot Invariant as a Constraint Satisfaction Problem

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    We point out the connection between mathematical knot theory and spin glass/search problem. In particular, we present a statistical mechanical formulation of the problem of computing a knot invariant; p-colorability problem, which provides an algorithm to find the solution. The method also allows one to get some deeper insight into the structural complexity of knots, which is expected to be related with the landscape structure of constraint satisfaction problem.Comment: 6 pages, 3 figures, submitted to short note in Journal of Physical Society of Japa

    On the fundamental group of the complement of a complex hyperplane arrangement

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    We construct two combinatorially equivalent line arrangements in the complex projective plane such that the fundamental groups of their complements are not isomorphic. The proof uses a new invariant of the fundamental group of the complement to a line arrangement of a given combinatorial type with respect to isomorphisms inducing the canonical isomorphism of the first homology groups.Comment: 12 pages, Latex2e with AMSLaTeX 1.2, no figures; this last version is almost the same as published in Functional Analysis and its Applications 45:2 (2011), 137-14
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