273 research outputs found

    The Impact of Individual Attitudinal and Organisational Variables on Workplace Environmentally Friendly Behaviours

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    Although research on corporate social responsibility (CSR) has grown steadily, little research has focused on CSR at the individual level. In addition, research on the role of environmental friendly organizational citizenship behaviors (OCBs) within CSR initiatives is scarce. In response to this gap and recent calls for further research on both individual and organizational variables of employees' environmentally friendly, or green, behaviors, this article sheds light on the influence of these variables on three types of green employee behaviors simultaneously: recycling, energy savings, and printing reduction. An initial theoretical model identifies both individual (employees' general environmentally friendly attitudes and the importance of an organization's environmentally friendly reputation to the employee) and organizational (perceived environmental behavior of an organization and perceived incentives and support from an organization) variables that affect different types of green behaviors as a stepping stone for further research. The results reveal managerial implications and future research directions on the design of effective social marketing interventions that motivate different types of OCBs in the workplace. In particular, the results suggest that creating separate interventions for each type of environmental behavior, as well as for each organization, sector, and type of organization (public vs. private), is necessary. In addition, this research illustrates patterns of attitudes, perceptions, and behaviors by exploring individual and organizational variables and behaviors across seven different organizations belonging to different sectors. © 2013 Springer Science+Business Media Dordrecht

    Green, keen, and somewhere in between: An employee environmental segmentation study

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    \ua9 2024 Elsevier Ltd. Past research analyzes employee engagement in pro-environmental behavior by assuming all employees are similar in their values, beliefs, and norms (VBN). We argue that a segmented approach is more effective in understanding workplace pro-environmental behaviors (PEBs) and seek to develop a typology of employees. Analyzing data from 702 office employees in the UK, this study yields a more finely grained segmentation of employee differences regarding environmental dimensions, personality traits, behaviors, and perceptions. Based on a cluster analysis methodology, this paper identifies three distinct employee segments: ‘Acorns,’ ‘Saplings,’ and ‘Trees.’ Theoretically, our findings suggest that the VBN theory should be expanded by integrating personality traits, and that organizational environmental policy makers should pay attention to the green subcultures that may form within clusters. Practically, our typology helps organizations design interventions to target different groups of employees with customized motivational strategies, communication tactics, and engagement approaches

    ‘Student Switch Off!’: how do university students respond to a corporate-sponsored pro-environmental social marketing campaign?

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    Sponsorship in pro-environmental social marketing campaigns has received limited academic attention within a higher education (HEI) context. This study examines how multi-level variables, i.e. individual (general environmental attitudes), organisational (scepticism toward the HEI’s environmental corporate social responsibility (CSR) initiatives; perceived HEI behaviour) and campaign-related (attitudes toward the advertisement; attitudes toward the corporate sponsor) factors, influence university students’ environmental intentions in response to a corporate-sponsored environmental initiative; using mixed methods (231 surveys and 40 interviews). Questionnaires revealed that scepticism toward the HEI’s CSR initiatives led to less positive perceptions of the HEI’s environmental behaviour, which decreased positive attitudes toward the advertisement and environmental intentions. Interviews revealed that the corporate sponsor seemed to motivate environmental behavioural intentions due to product discounts related to the sponsorship. Thus, a corporate sponsor may have confounding effects on pro-environmental behaviour campaigns. This has implications for the use of sponsorship in environmental social marketing campaigns

    Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA

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    BACKGROUND/OBJECTIVES: Whether fat-free mass (FFM) and its components are depleted in eating-disorder (ED) patients is uncertain. Dual energy X-ray absorptiometry (DXA) is widely used to assess body composition in pediatric ED patients; however, its accuracy in underweight populations remains unknown. We aimed (1) to assess body composition of young females with ED involving substantial weight loss, relative to healthy controls using the four-component (4C) model, and (2) to explore the validity of DXA body composition assessment in ED patients. SUBJECTS/METHODS: Body composition of 13 females with ED and 117 controls, aged 10-18 years, was investigated using the 4C model. Accuracy of DXA for estimation of FFM and fat mass (FM) was tested using the approach of Bland and Altman. RESULTS: Adjusting for age, height and pubertal stage, ED patients had significantly lower whole-body FM, FFM, protein mass (PM) and mineral mass (MM) compared with controls. Trunk and limb FM and limb lean soft tissue were significantly lower in ED patients. However, no significant difference in the hydration of FFM was detected. Compared with the 4C model, DXA overestimated FM by 5 +/- 36% and underestimated FFM by 1 +/- 9% in ED patients. CONCLUSION: Our study confirms that ED patients are depleted not only in FM but also in FFM, PM and MM. DXA has limitations for estimating body composition in individual young female ED patients

    Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates

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    <p>Abstract</p> <p>Background</p> <p>Fluorescent tags, including small organic molecules and fluorescent proteins, enable the localization of protein molecules in biomedical research experiments. However, the use of these labels may interfere with the formation of larger-scale protein structures such as amyloid aggregates. Therefore, we investigate the effects of some commonly used fluorescent tags on the morphologies of fibrils grown from the Alzheimer's disease-associated peptide Amyloid β 1-40 (Aβ40) and the Parkinson's disease-associated protein α-synuclein (αS).</p> <p>Results</p> <p>Using transmission electron microscopy (TEM), we verify that N-terminal labeling of Aβ40 with AMCA, TAMRA, and Hilyte-Fluor 488 tags does not prevent the formation of protofibrils and amyloid fibrils of various widths. We also measure the two-photon action cross-section of Aβ40 labelled with Hilyte Fluor 488 and demonstrate that this tag is suitable for use with two-photon fluorescence techniques. Similarly, we find that Alexa Fluor 488 labelling of αS variant proteins near either the N or C terminus (position 9 or 130) does not interfere with the formation of amyloid and other types of αS fibrils. We also present TEM images of fibrils grown from αS C-terminally labelled with enhanced green fluorescent protein (EGFP). Near neutral pH, two types of αS-EGFP fibrils are observed via TEM, while denaturation of the EGFP tag leads to the formation of additional species.</p> <p>Conclusions</p> <p>We demonstrate that several small extrinsic fluorescent tags are compatible with studies of amyloid protein aggregation. However, although fibrils can be grown from αS labelled with EGFP, the conformation of the fluorescent protein tag affects the observed aggregate morphologies. Thus, our results should assist researchers with label selection and optimization of solution conditions for aggregation studies involving fluorescence techniques.</p

    High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis.

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    BACKGROUND: The mammalian intestine is a complex biological system that exhibits functional plasticity in its response to diverse stimuli to maintain homeostasis. To improve our understanding of this plasticity, we performed a high-level data integration of 14 whole-genome transcriptomics datasets from samples of intestinal mouse mucosa. We used the tool Centrality based Pathway Analysis (CePa), along with information from the Reactome database. RESULTS: The results show an integrated response of the mouse intestinal mucosa to challenges with agents introduced orally that were expected to perturb homeostasis. We observed that a common set of pathways respond to different stimuli, of which the most reactive was the Regulation of Complement Cascade pathway. Altered expression of the Regulation of Complement Cascade pathway was verified in mouse organoids challenged with different stimuli in vitro. CONCLUSIONS: Results of the integrated transcriptomics analysis and data driven experiment suggest an important role of epithelial production of complement and host complement defence factors in the maintenance of homeostasis

    Primaquine in vivax malaria: an update and review on management issues

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    Primaquine was officially licensed as an anti-malarial drug by the FDA in 1952. It has remained the only FDA licensed drug capable of clearing the intra-hepatic schizonts and hypnozoites of Plasmodium vivax. This update and review focuses on five major aspects of primaquine use in treatment of vivax malaria, namely: a) evidence of efficacy of primaquine for its current indications; b) potential hazards of its widespread use, c) critical analysis of reported resistance against primaquine containing regimens; d) evidence for combining primaquine with artemisinins in areas of chloroquine resistance; and e) the potential for replacement of primaquine with newer drugs

    Applying science in practice: the optimization of biological therapy in rheumatoid arthritis

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    Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review explores the application of published evidence to practice, discussing the goals of treatment, the (in) ability to predict individual responses to therapy, and the potential value of indirect comparisons. We suggest that cycling of biological agents, until remission is achieved or until the most effective agent for that individual patient is determined, deserves consideration in the current stage of knowledge
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