335 research outputs found
Supersonic variable-cycle engines
The evolution and current status of selected recent variable cycle engine (VCE) studies are reviewed, and how the results were influenced by airplane requirements is described. Promising VCE concepts are described, their designs are simplified and the potential benefits in terms of aircraft performance are identified. This includes range, noise, emissions, and the time and effort it may require to ensure technical readiness of sufficient depth to satisfy reasonable economic, performance, and environmental constraints. A brief overview of closely related, ongoing technology programs in acoustics and exhaust emissions is also presented. Realistic technology advancements in critical areas combined with well matched aircraft and selected VCE concepts can lead to significantly improved economic and environmental performance relative to first generation SST predictions
Controlling of Iridium films using interfacial proximity effects
High precision calorimetry using superconducting transition edge sensors
requires the use of superconducting films with a suitable , depending on
the application. To advance high-precision macrocalorimetry, we require
low- films that are easy to fabricate. A simple and effective way to
suppress of superconducting Iridium through the proximity effect is
demonstrated by using Ir/Pt bilayers as well as Au/Ir/Au trilayers. While Ir/Au
films fabricated by applying heat to the substrate during Ir deposition have
been used in the past for superconducting sensors, we present results of
suppression on Iridium by deposition at room temperature in Au/Ir/Au trilayers
and Ir/Pt bilayers in the range of 20-100~mK. Measurements of the
relative impedance between the Ir/Pt bilayers and Au/Ir/Au trilayers fabricated
show factor of 10 higher values in the Ir/Pt case. These new films could
play a key role in the development of scalable superconducting transition edge
sensors that require low- films to minimize heat capacity and maximize
energy resolution, while keeping high-yield fabrication methods.Comment: 5 journal pages, 4 figure
CDMSlite: A Search for Low-Mass WIMPs using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment
SuperCDMS is an experiment designed to directly detect Weakly Interacting
Massive Particles (WIMPs), a favored candidate for dark matter ubiquitous in
the Universe. In this paper, we present WIMP-search results using a
calorimetric technique we call CDMSlite, which relies on voltage- assisted
Luke-Neganov amplification of the ionization energy deposited by particle
interactions. The data were collected with a single 0.6 kg germanium detector
running for 10 live days at the Soudan Underground Laboratory. A low energy
threshold of 170 eVee (electron equivalent) was obtained, which allows us to
constrain new WIMP-nucleon spin-independent parameter space for WIMP masses
below 6 GeV/c2.Comment: 7 pages, 4 figure
Potential therapeutic implications of new insights into respiratory syncytial virus disease
Viral bronchiolitis is the most common cause of hospitalization in infants under 6 months of age, and 70% of all cases of bronchiolitis are caused by respiratory syncytial virus (RSV). Early RSV infection is associated with respiratory problems such as asthma and wheezing later in life. RSV infection is usually spread by contaminated secretions and infects the upper then lower respiratory tracts. Infected cells release proinflammatory cytokines and chemokines, including IL-1, tumor necrosis factor-α, IL-6, and IL-8. These activate other cells and recruit inflammatory cells, including macrophages, neutrophils, eosinophils, and T lymphocytes, into the airway wall and surrounding tissues. The pattern of cytokine production by T lymphocytes can be biased toward 'T-helper-1' or 'T-helper-2' cytokines, depending on the local immunologic environment, infection history, and host genetics. T-helper-1 responses are generally efficient in antiviral defense, but young infants have an inherent bias toward T-helper-2 responses. The ideal intervention for RSV infection would be preventive, but the options are currently limited. Vaccines based on protein subunits, live attenuated strains of RSV, DNA vaccines, and synthetic peptides are being developed; passive antibody therapy is at present impractical in otherwise healthy children. Effective vaccines for use in neonates continue to be elusive but simply delaying infection beyond the first 6 months of life might reduce the delayed morbidity associated with infantile disease
Results from the Super Cryogenic Dark Matter Search (SuperCDMS) experiment at Soudan
We report the result of a blinded search for Weakly Interacting Massive
Particles (WIMPs) using the majority of the SuperCDMS Soudan dataset. With an
exposure of 1690 kg days, a single candidate event is observed, consistent with
expected backgrounds. This analysis (combined with previous Ge results) sets an
upper limit on the spin-independent WIMP--nucleon cross section of () cm at 46 GeV/. These results set the
strongest limits for WIMP--germanium-nucleus interactions for masses 12
GeV/
The Imperative to Share Clinical Study Reports: Recommendations from the Tamiflu Experience
Peter Doshi and colleagues describe their experience trying and failing to access clinical study reports from the manufacturer of Tamiflu and challenge industry to defend their current position of RCT data secrecy
Controlling of Iridium Films Using the Proximity Effect
A superconducting Transition-Edge Sensor (TES) with low- is essential in
a high resolution calorimetric detection. With a motivation of developing
sensitive calorimeters for applications in cryogenic neutrinoless double beta
decay searches, we have been investigating methods to reduce the of an Ir
film down to 20 mK. Utilizing the proximity effect between a superconductor and
a normal metal, we found two room temperature fabrication recipes of making
Ir-based low- films. In the first approach, an Ir film sandwiched between
two Au films, a Au/Ir/Au trilayer, has a tunable in the range of 20-100
mK depending on the relative thicknesses. In the second approach, a
paramagnetic Pt thin film is used to create Ir/Pt bilayer with a tunable
in the same range. We present detailed study of fabrication and
characterization of Ir-based low- films, and compare the experimental
results to theoretical models. We show that Ir-based films with predictable and
reproducible critical temperature can be consistently fabricated for use in
large scale detector applications.Comment: 5 figures, accepted in the Journal of Applied Physic
Detector Fabrication Yield for SuperCDMS Soudan
The SuperCDMS collaboration is presently operating a 9Â kg Ge payload at the Soudan Underground Laboratory in their direct search for dark matter. The Ge detectors utilize double-sided athermal phonon sensors with an interdigitated electrode structure (iZIPs) to reject near-surface electron-recoil events. These detectors each have a mass of 0.6Â kg and were fabricated with photolithographic techniques. The detector fabrication advances required and the production yield encountered are described.United States. Dept. of EnergyNational Science Foundation (U.S.
- …