The association between baseline persistent pain and weight change in patients attending a specialist weight management service

To quantify the influence of baseline pain levels on weight change at one-year follow-up in patients attending a National Health Service specialist weight management programme.We compared one-year follow-up weight (body mass) change between patient sub-groups of none-to-mild, moderate, and severe pain at baseline. A mean sub-group difference in weight change of ≥5kg was considered clinically relevant.Of the 141 complete cases, n = 43 (30.5%) reported none-to-mild pain, n = 44 (31.2%) reported moderate pain, and n = 54 (38.3%) reported severe pain. Covariate-adjusted mean weight loss (95%CI) was similar for those with none-to-mild (8.1kg (4.2 to 12.0kg)) and moderate pain (8.3kg (4.9 to 11.7kg). The mean weight loss of 3.0kg (-0.4 to 6.4kg) for the severe pain group was 5.1kg (-0.6 to 10.7, p = 0.08) lower than the none-to-mild pain group and 5.3kg (0.4 to 10.2kg, p = 0.03) lower than the moderate pain group.Patients with severe pain upon entry to a specialist weight management service in England achieve a smaller mean weight loss at one-year follow-up than those with none-to-moderate pain. The magnitude of the difference in mean weight loss was clinically relevant, highlighting the importance of addressing severe persistent pain in obese patients undertaking weight management programmes

DNA microarray revealed and RNAi plants confirmed key genes conferring low Cd accumulation in barley grains

List of genes down-regulated in both W6nk2 and Zhenong8 after 15 days exposure to 5 ΟM Cd. (DOC 130 kb

The Phytoene synthase gene family of apple (Malus x domestica) and its role in controlling fruit carotenoid content

Contains fulltext : 149076.pdf (publisher's version ) (Open Access

Growth responses of mutants of spring barley to fumigation with SO2 and NO2in combination.

This study was undertaken to evaluate the range of variation in growth responses of sodium azide-induced M2mutants (stocks SI and S2) of spring barley, Hordeum vulgare. L. cv. Maris Mink, in relation to air pollution tolerance or sensitivity. The preliminary screening experiment with 150 nl l−1concentrations of SO2 and NO2 in combination for 10 d, yielded well-defined sensitive and tolerant lines in both the stocks. However, the percentage frequency distribution of plants in different injury classes varied and stock S2 showed a better segregation of different lines. In a subsequent experiment, treatment with a mixture of each gas at 100 nl l−lconcentration for 22 d caused a variable degree of growth reduction. As a result of air pollution treatment, most of the growth parameters were significantly (P < 0.001) reduced in the sensitive lines of both the stocks, whereas the tolerant lines showed a marked resistance to the growth inhibitory effect of the pollutants. The magnitude of the difference between the sensitivities of different lines was usually double or more, and the effects were, more pronounced in stock S2 than in stock SI. Root dry weight was more adversely affected than shoot dry weight in sensitive lines of both the stocks. The results indicated that inter-line differences in growth responses of these mutants were wide ranging, distinct and consistent. In conclusion, this study clearly demonstrates that artificial mutations may cause a markedly broad base of variation in air pollution sensitivity of crop plants which may be used in future plant breeding programmes of pollution tolerant cultivars