6,717 research outputs found
A case of pleural mesothelioma with effusive-constrictive pericarditis.
A case report is presented of pleural mesothelioma with simultaneous development of benign effusive-constrictive pericarditis
Fluxoid formation: size effects and non-equilibrium universality
Simple causal arguments put forward by Kibble and Zurek suggest that the
scaling behaviour of condensed matter at continuous transitions is related to
the familiar universality classes of the systems at quasi-equilibrium. Although
proposed 25 years ago or more, it is only in the last few years that it has
been possible to devise experiments from which scaling exponents can be
determined and in which this scenario can be tested. In previous work, an
unusually high Kibble-Zurek scaling exponent was reported for spontaneous
fluxoid production in a single isolated superconducting Nb loop, albeit with
low density. Using analytic approximations backed up by Langevin simulations,
we argue that densities as small as these are too low to be attributable to
scaling, and are conditioned by the small size of the loop. We also reflect on
the physical differences between slow quenches and small rings, and derive some
criteria for these differences, noting that recent work on slow quenches does
not adequately explain the anomalous behaviour seen here.Comment: 7 pages, 4 figures, presentation given at CMMP 201
Highly syntenic and yet divergent: a tale of two Theilerias
The published genomic sequences of the two major host-transforming Theileria species of cattle represent a rich resource of information that has allowed novel bioinformatic and experimental studies into these important apicomplexan parasites. Since their publication in 2005, the genomes of T. annulata and T. parva have been utilised for a diverse range of applications, ranging from candidate antigen discovery to the identification of genetic markers for population analysis. This has led to advancements in the quest for a sub-unit vaccine, while providing a greater understanding of variation among parasite populations in the field. The unique ability of these Theileria species to induce host cell transformation is the subject of considerable scientific interest and the availability of full genomic sequences has provided new insights into this area of research. This article reviews the data underlying published comparative analyses, focussing on the general features of gene expression, the major Tpr/Tar multi-copy gene family and a re-examination of the predicted macroschizont secretome. Codon usage between the Theileria species is reviewed in detail, as this underpins ongoing comparative studies investigating selection at the intra- and inter-species level. The TashAT/TpshAT family of genes, conserved between T. annulata and T. parva, encodes products targeted to the host nucleus and has been implicated in contributing to the transformed bovine phenotype. Species-specific expansion and diversification at this critical locus is discussed with reference to the availability, in the near future, of genomic datasets which are based on non-transforming Theileria species
Soliton form factors from lattice simulations
The form factor provides a convenient way to describe properties of
topological solitons in the full quantum theory, when semiclassical concepts
are not applicable. It is demonstrated that the form factor can be calculated
numerically using lattice Monte Carlo simulations. The approach is very general
and can be applied to essentially any type of soliton. The technique is
illustrated by calculating the kink form factor near the critical point in
1+1-dimensional scalar field theory. As expected from universality arguments,
the result agrees with the exactly calculable scaling form factor of the
two-dimensional Ising model.Comment: 5 pages, 3 figures; v2: discussion extended, references added,
version accepted for publication in PR
Fractal Characterizations of MAX Statistical Distribution in Genetic Association Studies
Two non-integer parameters are defined for MAX statistics, which are maxima
of simpler test statistics. The first parameter, , is the
fractional number of tests, representing the equivalent numbers of independent
tests in MAX. If the tests are dependent, . The second
parameter is the fractional degrees of freedom of the chi-square
distribution that fits the MAX null distribution. These two
parameters, and , can be independently defined, and can be
non-integer even if is an integer. We illustrate these two parameters
using the example of MAX2 and MAX3 statistics in genetic case-control studies.
We speculate that is related to the amount of ambiguity of the model
inferred by the test. In the case-control genetic association, tests with low
(e.g. ) are able to provide definitive information about the disease
model, as versus tests with high (e.g. ) that are completely uncertain
about the disease model. Similar to Heisenberg's uncertain principle, the
ability to infer disease model and the ability to detect significant
association may not be simultaneously optimized, and seems to measure the
level of their balance
The number of conjugacy classes in pattern groups is not a polynomial function
A famous open problem due to Graham Higman asks if the number of conjugacy classes in the group of n x n unipotent upper triangular matrices over the q-element field can be expressed as a polynomial function of q for every fixed n. We consider the generalization of the problem for pattern groups and prove that for some pattern groups of nilpotency class two the number of conjugacy classes is not a polynomial function of q
Nonlinearly stacked low noise turbofan stator
A nonlinearly stacked low noise turbofan stator vane having a characteristic curve that is characterized by a nonlinear sweep and a nonlinear lean is provided. The stator is in an axial fan or compressor turbomachinery stage that is comprised of a collection of vanes whose highly three-dimensional shape is selected to reduce rotor-stator and rotor-strut interaction noise while maintaining the aerodynamic and mechanical performance of the vane. The nonlinearly stacked low noise turbofan stator vane reduces noise associated with the fan stage of turbomachinery to improve environmental compatibility
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