221 research outputs found
In Search of International Evidence: A Lawyer\u27s Guide through the United States Department of Justice
In Search of International Evidence: A Lawyer\u27s Guide through the United States Department of Justice
Changes in prostateâspecific antigen at the time of prostate cancer diagnosis after Medicaid expansion in young men
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155914/1/cncr32930_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155914/2/cncr32930.pd
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Safety Evaluation Report: Development of Improved Composite Pressure Vessels for Hydrogen Storage, Lincoln Composites, Lincoln, NE, May 25, 2010
Lincoln Composites operates a facility for designing, testing, and manufacturing composite pressure vessels. Lincoln Composites also has a U.S. Department of Energy (DOE)-funded project to develop composite tanks for high-pressure hydrogen storage. The initial stage of this project involves testing the permeation of high-pressure hydrogen through polymer liners. The company recently moved and is constructing a dedicated research/testing laboratory at their new location. In the meantime, permeation tests are being performed in a corner of a large manufacturing facility. The safety review team visited the Lincoln Composites site on May 25, 2010. The project team presented an overview of the company and project and took the safety review team on a tour of the facility. The safety review team saw the entire process of winding a carbon fiber/resin tank on a liner, installing the boss and valves, and curing and painting the tank. The review team also saw the new laboratory that is being built for the DOE project and the temporary arrangement for the hydrogen permeation tests
The DEEP Groth Strip Galaxy Redshift Survey. III. Redshift Catalog and Properties of Galaxies
The Deep Extragalactic Evolutionary Probe (DEEP) is a series of spectroscopic
surveys of faint galaxies, targeted at the properties and clustering of
galaxies at redshifts z ~ 1. We present the redshift catalog of the DEEP 1 GSS
pilot phase of this project, a Keck/LRIS survey in the HST/WFPC2 Groth Survey
Strip. The redshift catalog and data, including reduced spectra, are publicly
available through a Web-accessible database. The catalog contains 658 secure
galaxy redshifts with a median z=0.65, and shows large-scale structure walls to
z = 1. We find a bimodal distribution in the galaxy color-magnitude diagram
which persists to z = 1. A similar color division has been seen locally by the
SDSS and to z ~ 1 by COMBO-17. For red galaxies, we find a reddening of only
0.11 mag from z ~ 0.8 to now, about half the color evolution measured by
COMBO-17. We measure structural properties of the galaxies from the HST
imaging, and find that the color division corresponds generally to a structural
division. Most red galaxies, ~ 75%, are centrally concentrated, with a red
bulge or spheroid, while blue galaxies usually have exponential profiles.
However, there are two subclasses of red galaxies that are not bulge-dominated:
edge-on disks and a second category which we term diffuse red galaxies
(DIFRGs). The distant edge-on disks are similar in appearance and frequency to
those at low redshift, but analogs of DIFRGs are rare among local red galaxies.
DIFRGs have significant emission lines, indicating that they are reddened
mainly by dust rather than age. The DIFRGs in our sample are all at z>0.64,
suggesting that DIFRGs are more prevalent at high redshifts; they may be
related to the dusty or irregular extremely red objects (EROs) beyond z>1.2
that have been found in deep K-selected surveys. (abridged)Comment: ApJ in press. 24 pages, 17 figures (12 color). The DEEP public
database is available at http://saci.ucolick.org
The Rise of Massive Red Galaxies: the color-magnitude and color-stellar mass diagrams for z < ~2 from the MUltiwavelength Survey by Yale-Chile (MUSYC)
We present the color-magnitude and color-stellar mass diagrams for galaxies
with z_phot < ~2, based on a K < 22 (AB) catalog of the Extended Chandra Deep
Field South (ECDFS) from the MUltiwavelength Survey by Yale-Chile (MUSYC). Our
main sample of 7840 galaxies contains 1297 M_* > 10^11 M_Sol galaxies in the
range 0.2 < z_phot < 1.8. We show empirically that this catalog is
approximately complete for M_* > 10^11 M_Sol galaxies for z_phot < 1.8. For
this mass-limited sample, we show that the locus of the red sequence
color-stellar mass relation evolves as Del(u-r) ~ (-0.44+/-0.02) z_phot for
z_phot ~1.3, however, we are no longer able to reliably
distinguish red and blue subpopulations from the observed color distribution;
we show that this would require much deeper near infrared data. At 1.5 < z_phot
10^11 M_Sol galaxies is ~50% of the
local value, with a red fraction of ~33%. Making a parametric fit to the
observed evolution, we find n_tot(z) ~ (1+z_phot)^(-0.52+/-0.12(+/-0.20)). We
find stronger evolution in the red fraction: f_red(z) ~
(1+z_phot)^(-1.17+/-0.18(+/-0.21)). Through a series of sensitivity analyses,
we show that the most important sources of systematic error are: 1. systematic
differences in the analysis of the z~0 and z>>0 samples; 2. systematic effects
associated with details of the photometric redshift calculation; and 3.
uncertainties in the photometric calibration. With this in mind, we show that
our results based on photometric redshifts are consistent with a completely
independent analysis which does not require redshift information for individual
galaxies. Our results suggest that, at most, 1/5 of local red sequence galaxies
with M_* >10^11 M_Sol were already in place at z ~ 2.Comment: Accepted for publication in ApJ. 31 pages in emulateapj format; 18
figues (14 in main text). Additional online data available through
http://www.strw.leidenuniv.nl/~ent
Deep ugrizY imaging and DEEP2/3 spectroscopy: a photometric redshift testbed for LSST and public release of data from the DEEP3 Galaxy Redshift Survey
We present catalogues of calibrated photometry and spectroscopic redshifts in the Extended Groth Strip, intended for studies of photometric redshifts (photo-zâs). The data includes ugriz photometry from CanadaâFranceâHawaii Telescope Legacy Survey (CFHTLS) and Y-band photometry from the Subaru Suprime camera, as well as spectroscopic redshifts from the DEEP2, DEEP3, and 3D-HST surveys. These catalogues incorporate corrections to produce effectively matched-aperture photometry across all bands, based upon object size information available in the catalogue and Moffat profile point spread function fits. We test this catalogue with a simple machine learning-based photometric redshift algorithm based upon Random Forest regression, and find that the corrected aperture photometry leads to significant improvement in photo-z accuracy compared to the original SEXTRACTOR catalogues from CFHTLS and Subaru. The deep ugrizY photometry and spectroscopic redshifts are well suited for empirical tests of photometric redshift algorithms for LSST. The resulting catalogues are publicly available at http://d-scholarship.pitt.edu/36064/. We include a basic summary of the strategy of the DEEP3 Galaxy Redshift Survey to accompany the recent public release of DEEP3 data
The DEEP Groth Strip Survey. I. The Sample
The Deep Extragalactic Exploratory Probe (DEEP) is a multi-phase research
program dedicated to the study of the formation and evolution of galaxies and
of large scale structure in the distant Universe. This paper describes the
first five-year phase, denoted DEEP1. A series of ten DEEP1 papers will discuss
a range of scientific topics (e.g., the study of photometric and spectral
properties of a general distant galaxy survey, the evolution observed in galaxy
populations of varied morphologies). The observational basis for these studies
is the Groth Survey Strip field, a 127 square arcminute region which has been
observed with the Hubble Space Telescope in both broad I-band and V-band
optical filters and with the Low Resolution Imaging Spectrograph on the Keck
Telescopes. Catalogs of photometric and structural parameters have been
constructed for 11,547 galaxies and stars at magnitudes brighter than 29, and
spectroscopy has been conducted for a magnitude-color weighted subsample of 818
objects. We evaluate three independent techniques for constructing an imaging
catalog for the field from the HST data, and discuss the depth and sampling of
the resultant catalogs. The selection of the spectroscopic subsample is
discussed, and we describe the multifaceted approach taken to prioritizing
objects of interest for a variety of scientific subprograms. A series of Monte
Carlo simulations then demonstrates that the spectroscopic subsample can be
adequately modeled as a simple function of magnitude and color cuts in the
imaging catalog.Comment: ApJS accepted, 15 pages, 12 figures. Version with higher-quality
figures available at http://astronomy.nmsu.edu/nicol
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Comparison of Illumina and 454 Deep Sequencing in Participants Failing Raltegravir-Based Antiretroviral Therapy
Background: The impact of raltegravir-resistant HIV-1 minority variants (MVs) on raltegravir treatment failure is unknown. Illumina sequencing offers greater throughput than 454, but sequence analysis tools for viral sequencing are needed. We evaluated Illumina and 454 for the detection of HIV-1 raltegravir-resistant MVs. Methods: A5262 was a single-arm study of raltegravir and darunavir/ritonavir in treatment-naĂŻve patients. Pre-treatment plasma was obtained from 5 participants with raltegravir resistance at the time of virologic failure. A control library was created by pooling integrase clones at predefined proportions. Multiplexed sequencing was performed with Illumina and 454 platforms at comparable costs. Illumina sequence analysis was performed with the novel snp-assess tool and 454 sequencing was analyzed with V-Phaser. Results: Illumina sequencing resulted in significantly higher sequence coverage and a 0.095% limit of detection. Illumina accurately detected all MVs in the control library at â„0.5% and 7/10 MVs expected at 0.1%. 454 sequencing failed to detect any MVs at 0.1% with 5 false positive calls. For MVs detected in the patient samples by both 454 and Illumina, the correlation in the detected variant frequencies was high (R2 = 0.92, P<0.001). Illumina sequencing detected 2.4-fold greater nucleotide MVs and 2.9-fold greater amino acid MVs compared to 454. The only raltegravir-resistant MV detected was an E138K mutation in one participant by Illumina sequencing, but not by 454. Conclusions: In participants of A5262 with raltegravir resistance at virologic failure, baseline raltegravir-resistant MVs were rarely detected. At comparable costs to 454 sequencing, Illumina demonstrated greater depth of coverage, increased sensitivity for detecting HIV MVs, and fewer false positive variant calls
Gold Nanoparticle Delivery of Modified CpG Stimulates Macrophages and Inhibits Tumor Growth for Enhanced Immunotherapy
Gold nanoparticle accumulation in immune cells has commonly been viewed as a side effect for cancer therapeutic delivery;
however, this phenomenon can be utilized for developing gold nanoparticle mediated immunotherapy. Here, we
conjugated a modified CpG oligodeoxynucleotide immune stimulant to gold nanoparticles using a simple and scalable selfassembled
monolayer scheme that enhanced the functionality of CpG in vitro and in vivo. Nanoparticles can attenuate
systemic side effects by enhancing CpG delivery passively to innate effector cells. The use of a triethylene glycol (TEG) spacer
on top of the traditional poly-thymidine spacer increased CpG macrophage stimulatory effects without sacrificing DNA
content on the nanoparticle, which directly correlates to particle uptake. In addition, the immune effects of modified CpGAuNPs
were altered by the core particle size, with smaller 15 nm AuNPs generating maximum immune response. These TEG
modified CpG-AuNP complexes induced macrophage and dendritic cell tumor infiltration, significantly inhibited tumor
growth, and promoted survival in mice when compared to treatments with free CpG
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