Tesseract CubeSat Bus with Deployable Solar Panels

This project will aim to create a new CubeSat satellite structure that incorporates new subsystems to increase the manufacturability and versatility of PolySat’s standard satellite architecture. This new structure will incorporate deployable solar panels into the system, increasing power generation for the satellite. The structure of the CubeSat is vital to the overall system’s performance, and developing a standard high-performance system will allow for the integration of various payloads while minimizing the need for mission-specific customizations. This project will also allow for a majority of the structure to be manufactured in-house in the Cal Poly machine shops, allowing for the direct application of learn-by-doing. The integration of deployable solar panels will also involve design and fabrication of circuit boards. To complete these goals, we will leverage experience that we have had with the design and construction of previous CubeSats. Moreover, students have a chance to incorporate design processes that they have learned in various Cal Poly courses. This new structure will allow us to push the limits on what we can do with our already powerful CubeSat design. The design will allow us to provide higher performance to possible project sponsors, thus increasing the chance of winning future project proposals. Winning project proposals not only brings in funding for PolySat research projects, but also facilitates campus-wide development by bringing in additional funds for the university

A CD11d monoclonal antibody treatment reduces tissue injury and improves neurological outcome after fluid percussion brain injury in rats

Traumatic brain injury (TBI) is an international health concern often resulting in chronic neurological abnormalities, including cognitive deficits, emotional disturbances, and motor impairments. An anti-CD11d monoclonal antibody that blocks the CD11d/CD18 integrin and vascular cell adhesion molecule (VCAM)-1 interaction following experimental spinal cord injury improves functional recovery, while reducing the intraspinal number of neutrophils and macrophages, oxidative activity, and tissue damage. Since the mechanisms of secondary injury in the brain and spinal cord are similar, we designed a study to evaluate fully the effects of anti-CD11d treatment after a moderate lateral fluid percussion TBI in the rat. Rats were treated at 2 h after TBI with either the anti-CD11d antibody or an isotype-matched control antibody 1B7, and both short (24-to 72-h) and long (4-week) recovery periods were examined. The anti-CD11d integrin treatment reduced neutrophil and macrophage levels in the injured brain, with concomitant reductions in lipid peroxidation, astrocyte activation, amyloid precursor protein accumulation, and neuronal loss. The reduced neuroinflammation seen in anti-CD11d-treated rats correlated with improved performance on a number of behavioral tests. At 24 h, the anti-CD11d group performed significantly better than the 1B7 controls on several water maze measures of spatial cognition. At 4 weeks post-injury the anti-CD11d-treated rats had better sensorimotor function as assessed by the beam task, and reduced anxiety-like behaviors, as evidenced by elevated-plus maze testing, compared to 1B7 controls. These findings suggest that neuroinflammation is associated with behavioral deficits after TBI, and that anti-CD11d antibody treatment is a viable strategy to improve neurological outcomes after TBI. © 2012, Mary Ann Liebert, Inc

Lunar vertical-shaft mining system

This report proposes a method that will allow lunar vertical-shaft mining. Lunar mining allows the exploitation of mineral resources imbedded within the surface. The proposed lunar vertical-shaft mining system is comprised of five subsystems: structure, materials handling, drilling, mining, and planning. The structure provides support for the exploration and mining equipment in the lunar environment. The materials handling subsystem moves mined material outside the structure and mining and drilling equipment inside the structure. The drilling process bores into the surface for the purpose of collecting soil samples, inserting transducer probes, or locating ore deposits. Once the ore deposits are discovered and pinpointed, mining operations bring the ore to the surface. The final subsystem is planning, which involves the construction of the mining structure

A path to real-world evidence in critical care using open-source data harmonization tools

COVID-19 highlighted the need for use of real-world data (RWD) in critical care as a near real-time resource for clinical, research, and policy efforts. Analysis of RWD is gaining momentum and can generate important evidence for policy makers and regulators. Extracting high quality RWD from electronic health records (EHRs) requires sophisticated infrastructure and dedicated resources. We sought to customize freely available public tools, supporting all phases of data harmonization, from data quality assessments to de-identification procedures, and generation of robust, data science ready RWD from EHRs. These data are made available to clinicians and researchers through CURE ID, a free platform which facilitates access to case reports of challenging clinical cases and repurposed treatments hosted by the National Center for Advancing Translational Sciences/National Institutes of Health in partnership with the Food and Drug Administration. This commentary describes the partnership, rationale, process, use case, impact in critical care, and future directions for this collaborative effort

Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells

The fraction of experimentally active conserved non-coding sequences within any given cell type is low, so classical assays are unlikely to expose their potential

Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

Association between microvessel density (MVD) and tumor characteristics among breast cancer cases (n = 44). (DOC 54 kb

Demonstration of a Heterogeneous Satellite Architecture During RIMPAC 2018

The Micro-Satellite Military Utility (MSMU) Project Arrangement (PA) is an agreement under the Responsive Space Capabilities (RSC) Memorandum of Understanding (MOU) involving the Departments and Ministries of Defence of Australia, Canada, Germany, Italy, Netherlands, New Zealand, Norway, United Kingdom and United States. MSMU’s charter is to inform a space enterprise that provides military users with reliable access to a broad spectrum of information in an opportunistic environment. The MSMU community participated on a non-interference basis in the biennial Rim of the Pacific (RIMPAC) exercise from 26 June to 2 August 2018. This provided an opportunity to explore the military utility of a heterogeneous space architecture of satellites including traditional government and commercial satellites, as well as micro-satellites and nanosatellites associated with the “new space” paradigm. The objective was to test the hypothesis that a heterogeneous space architecture, mostly composed of small satellites, can bring significant value to the operational theatre. This paper describes the results from the MSMU experiment, outlines the lessons learned in terms of the infrastructure required to support such an experiment, and offers insights into the military utility of the heterogeneous space architecture. It concludes that a cooperative heterogeneous space architecture does have advantages and value, and that micro-satellites and nanosatellites contribute significant capability

An expansive human regulatory lexicon encoded in transcription factor footprints.

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcription factor occupancy events within regulatory regions, representing differential binding to 8.4 million distinct short sequence elements. Here we show that this small genomic sequence compartment, roughly twice the size of the exome, encodes an expansive repertoire of conserved recognition sequences for DNA-binding proteins that nearly doubles the size of the human cis-regulatory lexicon. We find that genetic variants affecting allelic chromatin states are concentrated in footprints, and that these elements are preferentially sheltered from DNA methylation. High-resolution DNase I cleavage patterns mirror nucleotide-level evolutionary conservation and track the crystallographic topography of protein-DNA interfaces, indicating that transcription factor structure has been evolutionarily imprinted on the human genome sequence. We identify a stereotyped 50-base-pair footprint that precisely defines the site of transcript origination within thousands of human promoters. Finally, we describe a large collection of novel regulatory factor recognition motifs that are highly conserved in both sequence and function, and exhibit cell-selective occupancy patterns that closely parallel major regulators of development, differentiation and pluripotency

Do Online, Offline, and Multiplatform Journalists Differ in their Professional Principles and Practices? Findings from a Multinational Study

Online journalists are often believed, not least in the industry itself, to follow different professional standards from their print and broadcast colleagues. There is, however, little empirical evidence to support or to refute this perception. This paper intends to help fill that gap by investigating whether offline and online journalists differ in their professional principles and practices. Drawing on previous conceptual research by Deuze, we operationalize the concept of journalism as an ideology comprising four ideal professional values: public service, objectivity, autonomy, and ethics. Using survey data from the Worlds of Journalism Study we compare professional principles and practices among online, offline, and multiplatform journalists in nine Western and Eastern European countries (N = 6,089). We find, contrary to previous research, that principles and practices among online and offline journalists broadly conform. However, we also find that online journalists are more likely than their offline colleagues to find justification for publishing unverified information and less interested in holding politicians to account, despite reporting that they have more freedom to select and frame news stories. We also find important differences between our samples of Western and Eastern European journalists