TcruziDB: an integrated, post-genomics community resource for Trypanosoma cruzi

TcruziDB () is an integrated post-genomics database for the parasitic organism, Trypanosoma cruzi, the causative agent of Chagas' disease. TcruziDB was established in 2003 as a flat-file database with tools for mining the unannotated sequence reads and preliminary contig assemblies emerging from the Tri-Tryp genome consortium (TIGR/SBRI/Karolinska). Today, TcruziDB houses the recently published assembled genomic contigs and annotation provided by the genome consortium in a relational database supported by the Genomics Unified Schema (GUS) architecture. The combination of an annotated genome and a relational architecture has facilitated the integration of genomic data with expression data (proteomic and EST) and permitted the construction of automated analysis pipelines. TcruziDB has accepted, and will continue to accept the deposition of genomic and functional genomic datasets contributed by the research community

Observations and simulation of a bottom Ekman layer on a continental shelf

A numerical model was used to simulate the bottom Ekman layer of a continental shelf region. The basis for the model was the Mellor and Yamada level 2 « turbulence closure scheme. Conservation equations for momentum, turbulent kinetic energy, and turbulent length scale were utilized in the model. The model was used to simulate data taken from a Cyclesonde mooring on the Peruvian continental shelf in May 1976 as part of the Joint II Coastal Upwelling Ecosystems Analysis program. The Cy-clesonde provided mean horizontal velocity, temperature, salinity, and pressure data. An intense pole-ward undercurrent drove the bottom flow regime. The most striking feature of the data was the clockwise Ekman veering of velocity vectors as the bottom was approached. A 48-hour period was chosen for the model simulations. The vertical profile of speed (48 hours mean) simulated by the model fell within the error bars of the data. The corresponding Ekman spiral display of the model results also showed good agreement with the observati. ons

Bottom dissipation of subinertial currents at the Atlantic zonal boundaries

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90515/1/jgr_bbldiss_wrightetal_2012.pd

An exploratory cluster randomised controlled trial of knowledge translation strategies to support evidence-informed decision-making in local governments (The KT4LG study)

Background: Childhood overweight and obesity is the most prevalent and, arguably, politically complex child health problem internationally. Governments, communities and industry have important roles to play, and are increasingly expected to deliver an evidence-informed system-wide prevention program. However, efforts are impeded by a lack of organisational access to and use of research evidence. This study aims to identify feasible, acceptable and ideally, effective knowledge translation (KT) strategies to increase evidence-informed decision making in local governments, within the context of childhood obesity prevention as a national policy priority.Methods/Design: This paper describes the methods for KT4LG, a cluster randomised controlled trial which is exploratory in nature, given the limited evidence base and methodological advances. KT4LG aims to examine a program of KT strategies to increase the use of research evidence in informing public health decisions in local governments. KT4LG will also assess the feasibility and acceptability of the intervention. The intervention program comprises a facilitated program of evidence awareness, access to tailored research evidence, critical appraisal skills development, networking and evidence summaries and will be compared to provision of evidence summaries alone in the control program. 28 local governments were randomised to intervention or control, using computer generated numbers, stratified by budget tertile (high, medium or low). Questionnaires will be used to measure impact, costs, and outcomes, and key informant interviews will be used to examine processes, feasibility, and experiences. Policy tracer studies will be included to examine impact of intervention on policies within relevant government policy documents.Discussion: Knowledge translation intervention studies with a focus on public health and prevention are very few in number. Thus, this study will provide essential data on the experience of program implementation and evaluation of a system-integrated intervention program employed within the local government public health context. Standardised programs of system, organisational and individual KT strategies have not been described or rigorously evaluated. As such, the findings will make a significant contribution to understanding whether a facilitated program of KT strategies hold promise for facilitating evidence-informed public health decision making within complex multisectoral government organisations.<br /

Research perspectives of sediment waves and drifts: Monitors of global change in deepwater circulation

The purpose of this special section in Paleoceanography is to present interdisciplinary approaches for contributing to the reconstruction of ocean circulation and its response to climate changes. A high-priority objective for understanding the causes and mechanisms of climate change is the monitoring of past ocean circulation and oceanic heat and nutrient transport. Lehman and Keigwin [1992] have shown that cooling, for example, during the younger Dryas event, may have culminated in a cessation of the oceans conveyor circulation. The cooling in the North Atlantic was apparently the result of reduced northward heat transport in the upper water masses of the North Atlantic conveyor belt. In contrast, intervals with a strong surface and deepwater circulation were marked by a high northward heat transport. For the understanding of the causes and the timing of such rapid,highfrequency events, marine records of high deposition ratecores are needed. These cores should provide evidence for changes in abyssal circulation and heat transport, as well as arecord of surface and deepwater characteristics. The sediment drifts of the North Atlantic and in other ocean basins are one of the major targets for the recovery of sediments with high deposition rates (>10 cm/kyr) and for reconstructing the role of both intermediate and deepwater production in the conveyor belt, that is drawing low-latitude heat northward. We stress the need for international programs targeting high deposition rate areas on sediment drifts and sediment waves in order to understand (1) the evolution of the conveyor belt and (2) its dynamics and variability. The North Atlantic, where sediment drifts are concentrated, will provide ideal study areas with time resolutions comparable to those of ice core records but with records linked directly to the record of changing bottom water flow. Therefore one can address the changes in circulation, heat and carbon budget on high and ultrahigh resolution records

Leadership and the Australian Greens

This paper examines the inherent tension between a Green political party’s genesis and official ideology and the conventional forms and practices of party leadership enacted in the vast bulk of other parties, regardless of their place on the ideological spectrum. A rich picture is painted of this ongoing struggle through a case study of the Australian Greens with vivid descriptions presented on organisational leadership issues by Australian state and federal Green members of parliaments. What emerges from the data is the Australian Green MPs’ conundrum in retaining an egalitarian and participatory democracy ethos while seeking to expand their existing frame of leadership to being both more pragmatic and oriented towards active involvement in government

Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services: protocol for a controlled before and after study

Background Clinical Commissioning Groups (CCGs) are mandated to use research evidence effectively to ensure optimum use of resources by the National Health Service (NHS), both in accelerating innovation and in stopping the use of less effective practices and models of service delivery. We intend to evaluate whether access to a demand-led evidence service improves uptake and use of research evidence by NHS commissioners compared with less intensive and less targeted alternatives. Methods/design This is a controlled before and after study involving CCGs in the North of England. Participating CCGs will receive one of three interventions to support the use of research evidence in their decision-making: 1) consulting plus responsive push of tailored evidence; 2) consulting plus an unsolicited push of non-tailored evidence; or 3) standard service unsolicited push of non-tailored evidence. Our primary outcome will be changed at 12 months from baseline of a CCGs ability to acquire, assess, adapt and apply research evidence to support decision-making. Secondary outcomes will measure individual clinical leads and managers’ intentions to use research evidence in decision making. Documentary evidence of the use of the outputs of the service will be sought. A process evaluation will evaluate the nature and success of the interactions both within the sites and between commissioners and researchers delivering the service. Discussion The proposed research will generate new knowledge of direct relevance and value to the NHS. The findings will help to clarify which elements of the service are of value in promoting the use of research evidence. Those involved in NHS commissioning will be able to use the results to inform how best to build the infrastructure they need to acquire, assess, adapt and apply research evidence to support decision-making and to fulfil their statutory duties under the Health and Social Care Act

Final Measurement of the U235 Antineutrino Energy Spectrum with the PROSPECT-I Detector at HFIR

This Letter reports one of the most precise measurements to date of the antineutrino spectrum from a purely U235-fueled reactor, made with the final dataset from the PROSPECT-I detector at the High Flux Isotope Reactor. By extracting information from previously unused detector segments, this analysis effectively doubles the statistics of the previous PROSPECT measurement. The reconstructed energy spectrum is unfolded into antineutrino energy and compared with both the Huber-Mueller model and a spectrum from a commercial reactor burning multiple fuel isotopes. A local excess over the model is observed in the 5MeV to 7MeV energy region. Comparison of the PROSPECT results with those from commercial reactors provides new constraints on the origin of this excess, disfavoring at 2.2 and 3.2 standard deviations the hypotheses that antineutrinos from U235 are solely responsible and non-contributors to the excess observed at commercial reactors respectively.Comment: The paper has been updated with an improved parametrization of the observed antineutrino spectrum excess and extended discussion on its potential isotopic origi