Proto-Brown Dwarf Disks as Products of Protostellar Disk Encounters

The formation of brown dwarfs via encounters between proto-stars has been confirmed with high-resolution numerical simulations with a restricted treatment of the thermal conditions. The new results indicate that young brown dwarfs (BDs) formed this way are disk-like and often reside in multiple systems. The newly-formed proto-BDs disks are up to 18 AU in size and spin rapidly making small-scale bipolar outflows, fragmentation and the possible formation of planetary companions likely as have recently been observed for BDs. The object masses range from 2 to 73 Jupiter masses, distributed in a manner consistent with the observed sub-stellar initial mass function. The simulations usually form multiple BDs on eccentric orbits about a star. One such system was hierarchical, a BD binary in orbit around a star, which may explain recently observed hierarchical systems. One third of the BDs were unbound after a few thousand years and interactions among orbiting BDs may eject more or add to the number of binaries. Improvements over prior work include resolution down to a Jupiter mass, self-consistent models of the vertical structure of the initial disks and careful attention to avoid artificial fragmentation.Comment: 4 pages, 3 figures, accepted for publication in ApJ Letter

Power law burst and inter-burst interval distributions in the solar wind: turbulence or dissipative SOC ?

We calculate for the first time the probability density functions (PDFs) P of burst energy e, duration T and inter-burst interval tau for a known turbulent system in nature. Bursts in the earth-sun component of the Poynting flux at 1 AU in the solar wind were measured using the MFI and SWE experiments on the NASA WIND spacecraft. We find P(e) and P(T) to be power laws, consistent with self-organised criticality (SOC). We find also a power law form for P(tau) that distinguishes this turbulent cascade from the exponential P(tau) of ideal SOC, but not from some other SOC-like sandpile models. We discuss the implications for the relation between SOC and turbulence.Comment: 3 pages, 1 figure. Submitted to PRL on 25th February 2000. Revised version re-submitted on 9th May 2000. Second revised version submitted Phys. Rev. E on 26th June, 200

Extreme-value statistics from Lagrangian convex hull analysis for homogeneous turbulent Boussinesq convection and MHD convection

We investigate the utility of the convex hull of many Lagrangian tracers to analyze transport properties of turbulent flows with different anisotropy. In direct numerical simulations of statistically homogeneous and stationary Navier-Stokes turbulence, neutral fluid Boussinesq convection, and MHD Boussinesq convection a comparison with Lagrangian pair dispersion shows that convex hull statistics capture the asymptotic dispersive behavior of a large group of passive tracer particles. Moreover, convex hull analysis provides additional information on the sub-ensemble of tracers that on average disperse most efficiently in the form of extreme value statistics and flow anisotropy via the geometric properties of the convex hulls. We use the convex hull surface geometry to examine the anisotropy that occurs in turbulent convection. Applying extreme value theory, we show that the maximal square extensions of convex hull vertices are well described by a classic extreme value distribution, the Gumbel distribution. During turbulent convection, intermittent convective plumes grow and accelerate the dispersion of Lagrangian tracers. Convex hull analysis yields information that supplements standard Lagrangian analysis of coherent turbulent structures and their influence on the global statistics of the flow.Comment: 18 pages, 10 figures, preprin

La unidad del pensamiento de Popper

Fil: Watkins, J. W. N. London School of Economics. Department of Philosophy, Logic and Scientific Method. Londres, Gran Bretañ

Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs

OBJECTIVE: To determine the influence of the single nucleotide polymorphism (SNP) rs4245739 on the binding and expression ofmicroRNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negativebreast cancers. METHODS: FindTar and miRanda were used to detect the manner in which potential microRNAs are affected by the SNPrs4245739-flanking sequence. RNA sequencing data for ER-negative breast cancer from The Cancer Genome Atlas (TCGA) wereused to compare the expression of miR-184, miR-191, miR-193a, miR-378, and MDM4 in different rs4245739 genotypes. RESULTS: Comparison of ER-negative cancer patients with and without the expression of miR-191 as well as profile microRNAs(miR-184, miR-191, miR-193a and miR-378 altogether) can differentiate the expression of MDM4 among different rs4245739genotypes. Although simple genotyping alone did not reveal significant clinical relationships, the combination of genotyping andmicroRNA profiles was able to significantly differentiate individuals with larger tumor size and lower number of involved lymphnodes (P < 0.05) in the risk group (A allele). CONCLUSIONS: We present two novel methods to analyze SNPs within 3′UTRs that use: (i) a single miRNA marker expression and(ii) an expression profile of miRNAs predicted to bind to the SNP region. We demonstrate that the application of these twomethods, in particular the miRNA profile approach, permits detection of new molecular and clinical features related to thers4245739 variant in ER-negative breast cancer

Acute lung injury in paediatric intensive care: course and outcome

Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) carry a high morbidity and mortality (10-90%). ALI is characterised by non-cardiogenic pulmonary oedema and refractory hypoxaemia of multifactorial aetiology [1]. There is limited data about outcome particularly in children. Methods This retrospective cohort study of 85 randomly selected patients with respiratory failure recruited from a prospectively collected database represents 7.1% of 1187 admissions. They include those treated with High Frequency Oscillation Ventilation (HFOV). The patients were admitted between 1 November 1998 and 31 October 2000. Results: Of the 85, 49 developed acute lung injury and 47 had ARDS. There were 26 males and 23 females with a median age and weight of 7.7 months (range 1 day-12.8 years) and 8 kg (range 0.8-40 kg). There were 7 deaths giving a crude mortality of 14.3%, all of which fulfilled the Consensus I [1] criteria for ARDS. Pulmonary occlusion pressures were not routinely measured. The A-a gradient and PaO2/FiO2 ratio (median + [95% CI]) were 37.46 [31.82-43.1] kPa and 19.12 [15.26-22.98] kPa respectively. The non-survivors had a significantly lower PaO2/FiO2 ratio (13 [6.07-19.93] kPa) compared to survivors (23.85 [19.57-28.13] kPa) (P = 0.03) and had a higher A-a gradient (51.05 [35.68-66.42] kPa) compared to survivors (36.07 [30.2-41.94]) kPa though not significant (P = 0.06). Twenty-nine patients (59.2%) were oscillated (Sensormedics 3100A) including all 7 non-survivors. There was no difference in ventilation requirements for CMV prior to oscillation. Seventeen of the 49 (34.7%) were treated with Nitric Oxide including 5 out of 7 non-survivors (71.4%). The median (95% CI) number of failed organs was 3 (1.96-4.04) for non-survivors compared to 1 (0.62-1.62) for survivors (P = 0.03). There were 27 patients with isolated respiratory failure all of whom survived. Six (85.7%) of the non-survivors also required cardiovascular support.Conclusion: A crude mortality of 14.3% compares favourably to published data. The A-a gradient and PaO2/FiO2 ratio may be of help in morbidity scoring in paediatric ARDS. Use of Nitric Oxide and HFOV is associated with increased mortality, which probably relates to the severity of disease. Multiple organ failure particularly respiratory and cardiac disease is associated with increased mortality. ARDS with isolated respiratory failure carries a good prognosis in children