Requirements for regional short-haul air service and the definition of a flight program to determine neighborhood reactions to small transport aircraft

An evaluation of the current status and future requirements of an intraregional short haul air service is given. A brief definition of the different types of short haul air service is given. This is followed by a historical review of previous attempts to develop short haul air service in high density urban areas and an assessment of the current status. The requirements for intraregional air service, the need for economic and environmental viability and the need for a flight research program are defined. A detailed outline of a research program that would determine urban community reaction to frequent operations of small transport aircraft is also given. Both the operation of such an experiment in a specific region (San Francisco Bay area) and the necessary design modifications of an existing fixed wing aircraft which could be used in the experiment are established. An estimate is made of overall program costs

Corporate Social Responsibility and the Nonprofit Sector: Assessing the Thoughts and Practices Across Three Nonprofit Subsectors

Scholars have increasingly been studying the impact of corporate social responsibility as a business strategy in for-profit institutions, and results frequently indicate benefits to the organizations such as increased reputation, sales, and reduced reputation damage during crises. Little is known about the impact of corporate social responsibility on organizations from the nonprofit sector, however. Using in-depth interviews with nonprofits sponsoring festivals in the San Francisco Bay Area in 2013-2014, this study examines how nonprofits representing agriculture, arts and culture, and sexual health view corporate social responsibility as it affects their communication efforts. Results indicate that nonprofit communicators downplay the corporate social responsibility behaviors in which they are engaged. When these efforts are communicated to external stakeholders, preference is given to less formal media channels

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent type I IFN response in infected cells, yet the IFN-inducing ligand remains unknown. In this report, we provide evidence that Chlamydia synthesizes cyclic di-AMP (c-di-AMP), a nucleic acid metabolite not previously identified in Gram-negative bacteria, and that this metabolite is a prominent ligand for STING-mediated activation of IFN responses during infection. We used primary mouse lung fibroblasts and HEK293T cells to compare IFN-β responses to Chlamydia infection, c-di-AMP, and other type I IFN-inducing stimuli. Chlamydia infection and c-di-AMP treatment induced type I IFN responses in cells expressing STING but not in cells expressing STING variants that cannot sense cyclic dinucleotides but still respond to cytoplasmic DNA. The failure to induce a type I IFN response to Chlamydia and c-di-AMP correlated with the inability of STING to relocalize from the endoplasmic reticulum to cytoplasmic punctate signaling complexes required for IFN activation. We conclude that Chlamydia induces STING-mediated IFN responses through the detection of c-di-AMP in the host cell cytosol and propose that c-di-AMP is the ligand predominantly responsible for inducing such a response in Chlamydia-infected cells.ImportanceThis study shows that the Gram-negative obligate pathogen Chlamydia trachomatis, a major cause of pelvic inflammatory disease and infertility, synthesizes cyclic di-AMP (c-di-AMP), a nucleic acid metabolite that thus far has been described only in Gram-positive bacteria. We further provide evidence that the host cell employs an endoplasmic reticulum (ER)-localized cytoplasmic sensor, STING (stimulator of interferon [IFN] genes), to detect c-di-AMP synthesized by Chlamydia and induce a protective IFN response. This detection occurs even though Chlamydia is confined to a membrane-bound vacuole. This raises the possibility that the ER, an organelle that innervates the entire cytoplasm, is equipped with pattern recognition receptors that can directly survey membrane-bound pathogen-containing vacuoles for leaking microbe-specific metabolites to mount type I IFN responses required to control microbial infections

RCW36: characterizing the outcome of massive star formation

Massive stars play a dominant role in the process of clustered star formation, with their feedback into the molecular cloud through ionizing radiation, stellar winds and outflows. The formation process of massive stars is poorly constrained because of their scarcity, the short formation timescale and obscuration. By obtaining a census of the newly formed stellar population, the star formation history of the young cluster and the role of the massive stars within it can be unraveled. We aim to reconstruct the formation history of the young stellar population of the massive star-forming region RCW 36. We study several dozens of individual objects, both photometrically and spectroscopically, look for signs of multiple generations of young stars and investigate the role of the massive stars in this process. We obtain a census of the physical parameters and evolutionary status of the young stellar population. Using a combination of near-infrared photometry and spectroscopy we estimate ages and masses of individual objects. We identify the population of embedded young stellar objects (YSO) by their infrared colors and emission line spectra. RCW 36 harbors a stellar population of massive and intermediate-mass stars located around the center of the cluster. Class 0/I and II sources are found throughout the cluster. The central population has a median age of 1.1 +/- 0.6 Myr. Of the stars which could be classified, the most massive ones are situated in the center of the cluster. The central cluster is surrounded by filamentary cloud structures; within these, some embedded and accreting YSOs are found. Our age determination is consistent with the filamentary structures having been shaped by the ionizing radiation and stellar winds of the central massive stars. The formation of a new generation of stars is ongoing, as demonstrated by the presence of embedded protostellar clumps, and two exposed jets.Comment: 18 pages, 10 figures, accepted for publication in Astronomy & Astrophysic

Development of a stratospheric and mesospheric microwave temperature sounder experiment

A passive microwave spectrometer system for measuring global atmospheric temperature profiles from 0-75 km altitude was developed and analyzed. The system utilizes 12 channels near the 5 mm wavelength oxygen absorption band and is designed to provide global coverage by scanning perpendicular to the orbital track of a polar orbiting satellite. A significant improvement in the accuracy of theoretical atmospheric microwave transmittance functions was achieved through the development of a first-order approximation to overlapping line theory for the oxygen molecule. This approximation is particularly important in the troposphere and lower stratosphere where pressure-broadening blends nearby lines. Ground-based and aircraft observations of several resonances of stratospheric oxygen generally support the theory. The 23, 25, 29, and 31 atmospheric oxygen lines were measured and the frequencies of several such oxygen lines were measured with improved precision. The polarization and Zeeman splitting of the atmospheric 27 line was also observed

A Parameter Study of Classical Be Star Disk Models Constrained by Optical Interferometry

We have computed theoretical models of circumstellar disks for the classical Be stars $\kappa$ Dra, $\beta$ Psc, and $\upsilon$ Cyg. Models were constructed using a non-LTE radiative transfer code developed by \citet{sig07} which incorporates a number of improvements over previous treatments of the disk thermal structure, including a realistic chemical composition. Our models are constrained by direct comparison with long baseline optical interferometric observations of the H$\alpha$ emitting regions and by contemporaneous H$\alpha$ line profiles. Detailed comparisons of our predictions with H$\alpha$ interferometry and spectroscopy place very tight constraints on the density distributions for these circumstellar disks.Comment: 10 figures,28 pages, accepted by Ap

An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers.

Prognostic information is essential for the evaluation, judgement and optimal treatment of patients with squamous cell cancers (SCCs) of the upper aerodigestive tract. Using immunohistochemical and flow cytometric techniques, we have studied the significance of cellular expression of the Ki-67 antigen, epidermal growth factor receptor (EGFR), the transferrin receptor (TFR) and DNA ploidy status in a prospective analysis of patients with SCCs of the head and neck region. All 42 fresh tumour samples (five well differentiated; 28 moderately differentiated; nine poorly differentiated) expressed both EGFR and TFR to varying degrees. Receptor expression was most marked on the peripheral invading margin of cancer cell islands although staining was also demonstrated in a random fashion within cellular islands and consistently along the basal cell layer of overlying stratified squamous epithelium. The percentage of cancer cells that reacted with the Ki-67 monoclonal antibody was assessed as low (less than 10%) in 15 samples (35.8%), intermediate (10-30%) in 19 samples (45.2%) and high (greater than 30%) in eight samples (19.0%). Eleven of 15 samples (73%) with a low percentage reactivity were DNA diploid, whereas seven of eight samples (87.5%) with a high percentage reactivity were DNA aneuploid. Poorly differentiated SCCs were significantly more often aneuploid than were either moderately or well differentiated tumours. Our results suggest that EGFR and TFR are widely distributed on SCCs, especially on proliferating cells at the invading tumour margin. In addition, there is a close spatial correlation between cells expressing EGFR, TFR and those expressing the Ki-67 antigen. Tumours in which the staining intensity for both EGFR and TFR was intense invariably expressed the Ki-67 antigen in a high proportion of cells. Further patient follow-up will be important in determining whether intense EGFR and TFR staining, combined with a high percentage reactivity with Ki-67 antibody and DNA aneuploidy, will ultimately define a subset of head and neck cancer patients with a poor clinical outcome

4U2206+54 - an Unusual High Mass X-ray Binary with a 9.6 Day Orbital Period but No Strong Pulsations

Rossi X-ray Timing Explorer All-Sky Monitor observations of the X-ray source 4U2206+54, previously proposed to be a Be star system, show the X-ray flux to be modulated with a period of approximately 9.6 days. If the modulation is due to orbital variability then this would be one of the shortest orbital periods known for a Be star X-ray source. However, the X-ray luminosity is relatively modest whereas a high luminosity would be predicted if the system contains a neutron star accreting from the denser inner regions of a Be star envelope. Although a 392s pulse period was previously reported from EXOSAT observations, a reexamination of the EXOSAT light curves does not show this or any other periodicity. An analysis of archival RXTE Proportional Counter Array observations also fails to show any X-ray pulsations. We consider possible models that may explain the properties of this source including a neutron star with accretion halted at the magnetosphere and an accreting white dwarf.Comment: Accepted for publication in the Astrophysical Journa