Impairment of spatial cognitive function with preservation of verbal performance during spatial disorientation

Spatial disorientation, which is responsible for up to 30% of aircraft accidents causes impairment of cognitive function which may further compromise a pilot's ability to think his way out of the situation and regain control [1,]. The functional-anatomical separation of spatial and verbal processing [10,11] raises the possibility of selective interference between the task of resolving spatial disorientation and the ability to perform concurrent spatial, as opposed to verbal, secondary tasks. We report for the first time a degradation of spatial task performance with preservation of verbal performance when subjects in a simulator are disoriented by conflict between self- motion and visual flow in the view of the external environment

The fastest unbound star in our Galaxy ejected by a thermonuclear supernova

Hypervelocity stars (HVS) travel with velocities so high, that they exceed the escape velocity of the Galaxy. Several acceleration mechanisms have been discussed. Only one HVS (US 708, HVS 2) is a compact helium star. Here we present a spectroscopic and kinematic analysis of US\,708. Travelling with a velocity of $\sim1200\,{\rm km\,s^{-1}}$, it is the fastest unbound star in our Galaxy. In reconstructing its trajectory, the Galactic center becomes very unlikely as an origin, which is hardly consistent with the most favored ejection mechanism for the other HVS. Furthermore, we discovered US\,708 to be a fast rotator. According to our binary evolution model it was spun-up by tidal interaction in a close binary and is likely to be the ejected donor remnant of a thermonuclear supernova.Comment: 16 pages report, 20 pages supplementary material

Variants of HCMV UL18 sequenced directly from clinical specimens associate with antibody and T-cell responses to HCMV

Around 80% of adults worldwide carry human cytomegaloviris (HCMV). The HCMV gene UL18 is a homolog of HLA class I genes and encodes a protein with high affinity for the NK and T-cell cytotoxicity inhibitor LIR-1. UL18 was deep sequenced from blood, saliva or urine from Indonesian people with HIV (PWH) (n = 28), Australian renal transplant recipients (RTR) (n = 21), healthy adults (n = 7) and neonates (n = 4). 95% of samples contained more than one variant of HCMV UL18, as defined by carriage of nonsynonymous variations. When aligned with immunological markers of the host’s burden of HCMV, the S318N variation associated with high levels of antibody reactive with HCMV lysate in PWH over 12 months on antiretroviral therapy. The A107T variation associated with HCMV antibody levels and inflammatory biomarkers in PWH at early timepoints. Variants D32G, D248N, V250A and E252D aligned with elevated HCMV antibody levels in RTR, while M191K, E196Q and F165L were associated with HCMV-reactive T-cells and proportions of Vδ2− γδ T-cells—populations linked with high burdens of HCMV. We conclude that UL18 is a highly variable gene, where variation may alter the persistent burden of HCMV and/or the host response to that burden

Gamma-rays from binary system with energetic pulsar and Be star with aspherical wind: PSR B1259-63/SS2883

At least one massive binary system containing an energetic pulsar, PSR B1259-63/SS2883, has been recently detected in the TeV gamma-rays by the HESS telescopes. These gamma-rays are likely produced by particles accelerated in the vicinity of the pulsar and/or at the pulsar wind shock, in comptonization of soft radiation from the massive star. However, the process of gamma-ray production in such systems can be quite complicated due to the anisotropy of the radiation field, complex structure of the pulsar wind termination shock and possible absorption of produced gamma-rays which might initiate leptonic cascades. In this paper we consider in detail all these effects. We calculate the gamma-ray light curves and spectra for different geometries of the binary system PSR B1259-63/SS2883 and compare them with the TeV gamma-ray observations. We conclude that the leptonic IC model, which takes into account the complex structure of the pulsar wind shock due to the aspherical wind of the massive star, can explain the details of the observed gamma-ray light curve.Comment: 12 pages, 11 figures, accepted for publication in MNRA

Probing the mass-loss history of AGB and red supergiant stars from CO rotational line profiles. I. Theoretical model - Mass-loss history unravelled in VY CMa

Context: Mass loss plays a dominant role in the evolution of low mass stars while they are on the Asymptotic Giant Branch (AGB). The gas and dust ejected during this phase are a major source in the mass budget of the interstellar medium. Recent studies have pointed towards the importance of variations in the mass-loss history of such objects. Aims: By modelling the full line profile of low excitation CO lines emitted in the circumstellar envelope, we can study the mass-loss history of AGB stars. Methods: We have developed a non-LTE radiative transfer code, which calculates the velocity structure and gas kinetic temperature of the envelope in a self-consistent way. The resulting structure of the envelope provides the input for the molecular line radiative calculations which are evaluated in the comoving frame. The code allows for the implementation of modulations in the mass-loss rate. This code has been benchmarked against other radiative transfer codes and is shown to perform well and efficiently. Results: We illustrate the effects of varying mass-loss rates in case of a superwind phase. The model is applied to the well-studied case of VY CMa. We show that both the observed integrated line strengths as the spectral structure present in the observed line profiles, unambiguously demonstrate that this source underwent a phase of high mass loss (~ 3.2E-4 Msun/yr) some 1000 yr ago. This phase took place for some 100 yr, and was preceded by a low mass-loss phase (~ 1E-6 Msun/yr) taking some 800 yr. The current mass-loss rate is estimated to be in the order of 8E-5 Msun/yr. Conclusions: In this paper, we demonstrate that both the relative strength of the CO rotational line profiles and the (non)-occurrence of spectral structure in the profile offer strong diagnostics to pinpoint the mass-loss history.Comment: 18 pages, 10 figures, accepted for publication in "Astronomy & Astrophysics

Shifting Attention From Theory to Practice in Philosophy of Biology

Traditional approaches in philosophy of biology focus attention on biological concepts, explanations, and theories, on evidential support and inter-theoretical relations. Newer approaches shift attention from concepts to conceptual practices, from theories to practices of theorizing, and from theoretical reduction to reductive retooling. In this article, I describe the shift from theory-focused to practice-centered philosophy of science and explain how it is leading philosophers to abandon fundamentalist assumptions associated with traditional approaches in philosophy of science and to embrace scientific pluralism. This article comes in three parts, each illustrating the shift from theory-focused to practice-centered epistemology. The first illustration shows how shifting philosophical attention to conceptual practice reveals how molecular biologists succeed in identifying coherent causal strands within systems of bewildering complexity. The second illustration suggests that analyzing how a multiplicity of alternative models function in practice provides an illuminating approach for understanding the nature of theoretical knowledge in evolutionary biology. The third illustration demonstrates how framing reductionism in terms of the reductive retooling of practice offers an informative perspective for understanding why putting DNA at the center of biological research has been incredibly productive throughout much of biology. Each illustration begins by describing how traditional theory-focused philosophical approaches are laden with fundamentalist assumptions and then proceeds to show that shifting attention to practice undermines these assumptions and motivates a philosophy of scientific pluralism

Long-term effects of prior diets, dietary transition and pregnancy on adipose gene expression in dairy heifers

peer-reviewedAdipose tissue is highly involved in whole-body metabolism and is the main site for lipid synthesis, storage and mobilization in ruminants. Therefore, knowledge about adipose tissue responses to different diets is important, especially in growing heifers as the feeding regimes of replacement heifers affect their future success as dairy cows. However, at gene expression level such knowledge is limited. As part of a larger feed trial, adipose tissue biopsies from 24 Norwegian Red heifers were collected at 12 months of age (12MO) and at month seven of gestation (PREG) and analyzed by next-generation mRNA sequencing. Between these two sampling points, all heifers had gone through a successful conception and a feed change from four dietary treatments of high or low energy (HE/LE) and protein (HP/LP) content (treatments LPHE, HPHE, LPLE and HPLE) to a low-energy, low-protein pregnancy feed given to all animals. Gene expression differences between different feed treatments at 12MO are described in an earlier publication from our group. The main objectives of this study were to investigate the long-term effects of diets differing in protein and energy density level on gene expression in adipose tissue of growing replacement dairy heifers. To achieve this, we examined the post-treatment effects between the treatment groups at month seven of gestation; 6 months after the termination of experimental feeding, and the long-term gene expression changes occurring in the adipose tissue between 12MO and PREG. Post-treatment group comparisons showed evidence of long-term effects of dietary treatment on adipose gene expression. Differences between protein treatments were smaller than between energy treatments. Adipose gene expression changes from 12MO to PREG were much larger for the HE than the LE treatments and seemed to mostly be explained by the characteristics of the diet change. 97 genes displayed a unidirectional expression change for all groups from 12MO to PREG, and are considered to be treatment-independent, possibly caused by pregnancy or increased age. This study provides candidate genes and key regulators for further studies on pregnancy preservation (TGFB1, CFD) and metabolic regulation and efficiency (PI3K, RICTOR, MAP4K4,) in dairy cattle

Modeling interaction of relativistic and nonrelativistic winds in binary system PSR 1259-63/SS2883. I.Hydrodynamical limit

In this paper, we present a detailed hydrodynamical study of the properties of the flow produced by the collision of a pulsar wind with the surrounding in a binary system. This work is the first attempt to simulate interaction of the ultrarelativistic flow (pulsar wind) with the nonrelativistic stellar wind. Obtained results show that the wind collision could result in the formation of an "unclosed" (at spatial scales comparable to the binary system size) pulsar wind termination shock even when the stellar wind ram pressure exceeds significantly the pulsar wind kinetical pressure. Moreover, the post-shock flow propagates in a rather narrow region, with very high bulk Lorentz factor ($\gamma\sim100$). This flow acceleration is related to adiabatical losses, which are purely hydrodynamical effects. Interestingly, in this particular case, no magnetic field is required for formation of the ultrarelativistic bulk outflow. The obtained results provide a new interpretation for the orbital variability of radio, X-ray and gamma-ray signals detected from binary pulsar system PSR 1259-63/SS2883.Comment: 11 pages, 13 figures, submitted to MNRA