4U2206+54 - an Unusual High Mass X-ray Binary with a 9.6 Day Orbital Period but No Strong Pulsations

Rossi X-ray Timing Explorer All-Sky Monitor observations of the X-ray source 4U2206+54, previously proposed to be a Be star system, show the X-ray flux to be modulated with a period of approximately 9.6 days. If the modulation is due to orbital variability then this would be one of the shortest orbital periods known for a Be star X-ray source. However, the X-ray luminosity is relatively modest whereas a high luminosity would be predicted if the system contains a neutron star accreting from the denser inner regions of a Be star envelope. Although a 392s pulse period was previously reported from EXOSAT observations, a reexamination of the EXOSAT light curves does not show this or any other periodicity. An analysis of archival RXTE Proportional Counter Array observations also fails to show any X-ray pulsations. We consider possible models that may explain the properties of this source including a neutron star with accretion halted at the magnetosphere and an accreting white dwarf.Comment: Accepted for publication in the Astrophysical Journa

Heterogeneous genetic basis of age at maturity in salmonid fishes

Understanding the genetic basis of repeated evolution of the same phenotype across taxa is a fundamental aim in evolutionary biology and has applications in conservation and management. However, the extent to which interspecific life-history trait polymorphisms share evolutionary pathways remains underexplored. Here, we address this gap by studying the genetic basis of a key life-history trait, age at maturity, in four species of Pacific salmonids (genus Oncorhynchus) that exhibit intra- and interspecific variation in this trait-Chinook Salmon, Coho Salmon, Sockeye Salmon, and Steelhead Trout. We tested for associations in all four species between age at maturity and two genome regions, six6 and vgll3, that are strongly associated with the same trait in Atlantic Salmon (Salmo salar). We also conducted a genome-wide association analysis in Steelhead to assess whether additional regions were associated with this trait. We found the genetic basis of age at maturity to be heterogeneous across salmonid species. Significant associations between six6 and age at maturity were observed in two of the four species, Sockeye and Steelhead, with the association in Steelhead being particularly strong in both sexes (p = 4.46 x 10(-9) after adjusting for genomic inflation). However, no significant associations were detected between age at maturity and the vgll3 genome region in any of the species, despite its strong association with the same trait in Atlantic Salmon. We discuss possible explanations for the heterogeneous nature of the genetic architecture of this key life-history trait, as well as the implications of our findings for conservation and management.Peer reviewe

Genome-Wide microRNA Binding Site Variation between Extinct Wild Aurochs and Modern Cattle Identifies Candidate microRNA-Regulated Domestication Genes

peer-reviewedThe domestication of cattle from the now-extinct wild aurochs (Bos primigenius) involved selection for physiological and behavioral traits, with underlying genetic factors that remain largely unknown. Non-coding microRNAs have emerged as key regulators of the spatio-temporal expression of target genes controlling mammalian growth and development, including in livestock species. During the domestication process, selection of mutational changes in miRNAs and/or miRNA binding sites could have provided a mechanism to generate some of the traits that differentiate domesticated cattle from wild aurochs. To investigate this, we analyzed the open reading frame DNA sequence of 19,994 orthologous protein-coding gene pairs from extant Bos taurus genomes and a single extinct B. primigenius genome. We identified miRNA binding site polymorphisms in the 3′ UTRs of 1,620 of these orthologous genes. These 1,620 genes with altered miRNA binding sites between the B. taurus and B. primigenius lineages represent candidate domestication genes. Using a novel Score Site ratio metric we have ranked these miRNA-regulated genes according to the extent of divergence between miRNA binding site presence, frequency and copy number between the orthologous genes from B. taurus and B. primigenius. This provides an unbiased approach to identify cattle genes that have undergone the most changes in miRNA binding (i.e., regulation) between the wild aurochs and modern-day cattle breeds. In addition, we demonstrate that these 1,620 candidate domestication genes are enriched for roles in pigmentation, fertility, neurobiology, metabolism, immunity and production traits (including milk quality and feed efficiency). Our findings suggest that directional selection of miRNA regulatory variants was important in the domestication and subsequent artificial selection that gave rise to modern taurine cattle

A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors.

To improve clinicians\u27 ability to predict outcome after spinal cord injury (SCI) and to help classify patients within clinical trials, we have created a novel prediction model relating acute clinical and imaging information to functional outcome at 1 year. Data were obtained from two large prospective SCI datasets. Functional independence measure (FIM) motor score at 1 year follow-up was the primary outcome, and functional independence (score ≥ 6 for each FIM motor item) was the secondary outcome. A linear regression model was created with the primary outcome modeled relative to clinical and imaging predictors obtained within 3 days of injury. A logistic model was then created using the dichotomized secondary outcome and the same predictor variables. Model validation was performed using a bootstrap resampling procedure. Of 729 patients, 376 met the inclusion criteria. The mean FIM motor score at 1 year was 62.9 (±28.6). Better functional status was predicted by less severe initial American Spinal Injury Association (ASIA) Impairment Scale grade, and by an ASIA motor score \u3e50 at admission. In contrast, older age and magnetic resonance imaging (MRI) signal characteristics consistent with spinal cord edema or hemorrhage predicted worse functional outcome. The linear model predicting FIM motor score demonstrated an R-square of 0.52 in the original dataset, and 0.52 (95% CI 0.52,0.53) across the 200 bootstraps. Functional independence was achieved by 148 patients (39.4%). For the logistic model, the area under the curve was 0.93 in the original dataset, and 0.92 (95% CI 0.92,0.93) across the bootstraps, indicating excellent predictive discrimination. These models will have important clinical impact to guide decision making and to counsel patients and families

Spatially resolving polycyclic aromatic hydrocarbons in Herbig Ae disks with VISIR-NEAR at the VLT

We use the long-slit spectroscopy mode of the VISIR-NEAR experiment to perform diffraction-limited observations of eight nearby Herbig Ae protoplanetary disks. We extract spectra for various locations along the slit with a spectral resolution of R = 300 and perform a compositional fit at each spatial location using spectral templates of silicates and the four PAH bands. This yields the intensity vs. location profiles of each species. Results. We could obtain spatially-resolved intensity profiles of the PAH emission features in the N-band for five objects (AB Aurigae, HD 97048, HD 100546, HD 163296, and HD 169142). We observe two kinds of PAH emission geometry in our sample: centrally-peaked (HD 97048) and ring-like (AB Aurigae, HD 100546, HD 163296, and potentially HD 169142). Comparing the spatial PAH emission profiles with near-infrared scattered light images, we find a strong correlation in the disk sub-structure but a difference in radial intensity decay rate. The PAH emission shows a less steep decline with distance from the star. Finally, we find a correlation between the presence of (sub-) micron-sized silicate grains leading to the depletion of PAH emission within the inner regions of the disks. In this work, we find the following: (1) PAH emission traces the extent of Herbig Ae disks to a considerable radial distance. (2) The correlation between silicate emission within the inner regions of disks and the depletion of PAH emission can result from dust-mixing and PAH coagulation mechanisms and competition over UV photons. (3) For all objects in our sample, PAHs undergo stochastic heating across the entire spatial extent of the disk and are not saturated. (4) The difference in radial intensity decay rates between the PAHs and scattered-light profiles may be attributed to shadowing and dust-settling effects, which affect the scattering grains more than the PAHs

Mid-Infrared Imaging of Candidate Vega-Like Systems

We have conducted deep mid-infrared imaging of a relatively nearby sample of candidate Vega-like stars using the OSCIR instrument on the CTIO 4-meter and Keck II 10-meter telescopes. Our discovery of a spatially-resolved disk around HR 4796A has already been reported (Jayawardhana et al. 1998). Here we present imaging observations of the other members of the sample, including the discovery that only the primary in the HD 35187 binary system appears to harbor a substantial circumstellar disk and the possible detection of extended disk emission around 49 Ceti. We derive global properties of the dust disks, place constraints on their sizes, and discuss several interesting cases in detail. Although our targets are believed to be main sequence stars, we note that several have large infrared excesses compared to prototype Vega-like systems, and may therefore be somewhat younger. The disk size constraints we derive, in many cases, imply emission from relatively large ($\gtrsim$ 10$\mu$m) particles at mid-infrared wavelengths.Comment: 15 pages and 2 PostScript figures, accepted for publication in The Astronomical Journa

‘Instead of fetching flowers, the youths brought in flakes of snow’: exploring extreme weather history through English parish registers

Parish registers provide organized, dated and located population data and as such, are routinely among the most frequently consulted documents within the holdings of county record offices and archives. Throughout history, extreme weather has had significant impacts on the church, its congregation, and local landscape. It is for these reasons that extreme weather events have been deemed worthy of official note by authors of many registers. Although isolated entries have been used as supporting evidence for the occurrence of a number of historic extreme weather events, the information that parish registers contain relating to weather history has not been studied in its own right. Parish register narratives add new events to existing chronologies of extreme weather events and contribute to our understanding of their impacts at the local level. As public and well used documents they also function to keep the memory of particular events alive. The examples in this paper cover a wide range of weather types, places, and time periods, also enabling recording practice to be explored. Finally, as the number of digitized registers increases, we highlight the risks of weather narratives being obscured, and reflect on how the weather history contained within might be systematically captured

Individual and Contextual Factors Associated with Low Childhood Immunisation Coverage in Sub-Saharan Africa: A Multilevel Analysis

Background: In 2010, more than six million children in sub-Saharan Africa did not receive the full series of three doses of the diphtheria-tetanus-pertussis vaccine by one year of age. An evidence-based approach to addressing this burden of un-immunised children requires accurate knowledge of the underlying factors. We therefore developed and tested a model of childhood immunisation that includes individual, community and country-level characteristics. Method and Findings: We conducted multilevel logistic regression analysis of Demographic and Health Survey data for 27,094 children aged 12–23 months, nested within 8,546 communities from 24 countries in sub-Saharan Africa. According to the intra-country and intra-community correlation coefficient implied by the estimated intercept component variance, 21% and 32% of the variance in unimmunised children were attributable to country- and community-level factors respectively. Children born to mothers (OR 1.35, 95%CI 1.18 to 1.53) and fathers (OR 1.13, 95%CI 1.12 to 1.40) with no formal education were more likely to be unimmunised than those born to parents with secondary or higher education. Children from the poorest households were 36% more likely to be unimmunised than counterparts from the richest households. Maternal access to media significantly reduced the odds of children being unimmunised (OR 0.94, 95%CI 0.94 to 0.99). Mothers with health seeking behaviours were less likely to have unimmunised children (OR 0.56, 95%CI 0.54 to 0.58). However, children from urban areas (OR 1.12, 95% CI 1.01 to 1.23), communities with high illiteracy rates (OR 1.13, 95% CI 1.05 to 1.23), and countries with high fertility rates (OR 4.43, 95% CI 1.04 to 18.92) were more likely to be unimmunised. Conclusion: We found that individual and contextual factors were associated with childhood immunisation, suggesting that public health programmes designed to improve coverage of childhood immunisation should address people, and the communities and societies in which they live