Neuroinflammation in Preclinical Alzheimer's Disease: A Review of Current Evidence

The pathology of sporadic Alzheimer’s disease (AD) may be present at mid-life and precede the prodromal and clinical dementia syndromes associated with the disorder by decades. Few successful therapeutic treatments exist and, as a result, attention is turning to the preclinical stages of the disease for the development of future intervention strategies. The success of such strategies will rely on well-defined biomarkers of preclinical disease to identify and monitor changes earlier in the disease course. Here, we consider whether immune function changes are potentially useful markers of preclinical disease. We have selected studies spanning epidemiological, animal, clinical and imaging research pertaining to the earliest stages of AD pathogenesis, as well as studies of non-demented adults at high AD risk. We examine changes in inflammatory markers, alongside changes in established biomarkers, to highlight their suitability as disease indicators across preclinical and prodromal stages. We conclude that further work surrounding this topic is required, calling for larger prospective epidemiological studies of preclinical disease that incorporate serial assessment designs with a wider range of inflammatory mediators. We anticipate that future benefits of work in this area include improved disease detection and modification, as well as diagnostic accuracy of trial participants, leading to more cost-effective observation and intervention studies

Selling impact: how is impact peer reviewed and what does this mean for the future of impact in universities?

Despite a wealth of guidance from HEFCE, impact evaluation in the run-up to REF2014 was a relatively new experience for universities. How it was undertaken remains largely opaque. Richard Watermeyer and Adam Hedgecoe share their findings from a small but intensive ethnographic study of impact peer-review undertaken in one institution. Observations palpably confirmed a sense of a voyage into the unknown. Due to the confusion and uncertainty, there was a tendency to prioritise hard (or more immediately certain) impacts over those deemed more soft (or nebulous)

Goal-orientated cognitive rehabilitation for dementias associated with Parkinson's disease―A pilot randomised controlled trial

OBJECTIVE: To examine the appropriateness and feasibility of cognitive rehabilitation for people with dementias associated with Parkinson's in a pilot randomised controlled study. METHODS: This was a single-blind pilot randomised controlled trial of goal-oriented cognitive rehabilitation for dementias associated with Parkinson's. After goal setting, participants were randomised to cognitive rehabilitation (n = 10), relaxation therapy (n = 10), or treatment-as-usual (n = 9). Primary outcomes were ratings of goal attainment and satisfaction with goal attainment. Secondary outcomes included quality of life, mood, cognition, health status, everyday functioning, and carers' ratings of goal attainment and their own quality of life and stress levels. Assessments were at 2 and 6 months following randomisation. RESULTS: At 2 months, cognitive rehabilitation was superior to treatment-as-usual and relaxation therapy for the primary outcomes of self-rated goal attainment (d = 1.63 and d = 1.82, respectively) and self-rated satisfaction with goal attainment (d = 2.04 and d = 1.84). At 6 months, cognitive rehabilitation remained superior to treatment-as-usual (d = 1.36) and relaxation therapy (d = 1.77) for self-rated goal attainment. Cognitive rehabilitation was superior to treatment as usual and/or relaxation therapy in a number of secondary outcomes at 2 months (mood, self-efficacy, social domain of quality of life, carers' ratings of participants' goal attainment) and at 6 months (delayed recall, health status, quality of life, carer ratings of participants' goal attainment). Carers receiving cognitive rehabilitation reported better quality of life, health status, and lower stress than those allocated to treatment-as-usual. CONCLUSIONS: Cognitive rehabilitation is feasible and potentially effective for dementias associated with Parkinson's disease

A conceptualisation of the post-museum as pedagogical space

This paper explores the idea of the post-museum as an immersive knowledgeexperience facilitating conceptual and strategic directions in public engagement with science and technology. It considers the extent to which the museum has evolved from repository of cultural artefacts to experience-based process of knowledge acquisition and production. The post-museum is invoked as a model of participatory pedagogy that moves beyond traditional forms of learning,knowledge acquisition and knowledge interface, and conceptualisations of the learner in science. It is presented as an educational and recreational experience, which locates and translates knowledge to the novice or non-traditional patron using rich social narratives that ground scientific expertise in the practice of everyday life. The experience of science is thus made familiar and relevant and concurrently regulated and owned by the visitor. The learner is consequentlyrecast from passive recipient of information-bites to choreographer, translator and innovator within a scientific knowledge continuum

Impact 'agenda' or impact 'phantom'?

Responding to an emerging debate around the changing nature of the impact agenda in the UK, Richard Watermeyer, argues that the current moment presents a point of change; an opportunity to exorcise the ghosts of previous regimes of incentivising and assessing impact, and step towards a more meaningful social compact

Contact, the feature pool and the speech community : The emergence of Multicultural London English.

In Northern Europe’s major cities, new varieties of the host languages are emerging in the multilingual inner cities. While some analyse these ‘multiethnolects’ as youth styles, we take a variationist approach to an emerging ‘Multicultural London English’ (MLE), asking: (1) what features characterise MLE? (2) at what age(s) are they acquired? (3) is MLE vernacularised? (4) when did MLE emerge, and what factors enabled its emergence? We argue that innovations in the diphthongs and the quotative system are generated from the specific sociolinguistics of inner-city London, where at least half the population is undergoing group second-language acquisition and where high linguistic diversity leads to a feature pool to select from. We look for incrementation (Labov) in the acquisition of the features, but find this only for two ‘global’ changes, BE LIKE and GOOSE-fronting, for which adolescents show the highest usage. Community-internal factors explain the age-related variation in the remaining features

Pregnancy and inflammatory bowel disease Gill

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