Digital Library Education: Some International Course Structure Comparisons

Digital Library Education (DLE) is assuming increasing importance and it is clear there is a pressing need from social trends and technology for educational developments in this new and fast moving area [1, 3]. Our latest review of progress in DLE and other recent studies [1, 2] pointed out that the number of library schools offering DL education is still growing. By the end of 2006 (based on modules titles shown on-line), 28% (5/18) of all universities with accredited programmes by CILIP (the Chartered Institute of Library and Information Professionals) in the UK and over 60% (34/56) of all library schools by ALA (American Library Association) in the USA and Canada are offering specific DL education. Around 40% of DLE is now either specialized independent or certificate programmes and courses, mainly in North America. However, there is currently no widely accepted formal curriculum framework for digital librarianship [2]. A major difficulty for academics in library and information science (LIS) is how to incorporate all of the DL technologies to their DLE, and no formal widely accepted framework of DLE has yet been established [1, 2, 3, 4]. It is difficult to compare full-scale independent programmes with other programmes that are more traditionally-based but which have modules on DLs [3, 4]. This and others recent studies [1, 2, 5] show there is a pressing need for educators to explore the specific question of what should be the standard framework for DLE in LIS to ensure that students and their employers – can be assured of having an adequate skill set to work confidently and productively in this area. DLE taught in a Computer Science environment benefits from an outline framework from CC2001 but no such framework has yet been promulgated from LIS based programmes [1, 2]

Manipulating the enone moiety of levoglucosenone: 1,3-Transposition reactions including ones leading to isolevoglucosenone

This research was part-funded by Circa Group Pty Ltd

Digital Library Education: Some International Course Structure Comparisons

Digital Library Education (DLE) is assuming increasing importance and it is clear there is a pressing need from social trends and technology for educational developments in this new and fast moving area [1, 3]. Our latest review of progress in DLE and other recent studies [1, 2] pointed out that the number of library schools offering DL education is still growing. By the end of 2006 (based on modules titles shown on-line), 28% (5/18) of all universities with accredited programmes by CILIP (the Chartered Institute of Library and Information Professionals) in the UK and over 60% (34/56) of all library schools by ALA (American Library Association) in the USA and Canada are offering specific DL education. Around 40% of DLE is now either specialized independent or certificate programmes and courses, mainly in North America. However, there is currently no widely accepted formal curriculum framework for digital librarianship [2]. A major difficulty for academics in library and information science (LIS) is how to incorporate all of the DL technologies to their DLE, and no formal widely accepted framework of DLE has yet been established [1, 2, 3, 4]. It is difficult to compare full-scale independent programmes with other programmes that are more traditionally-based but which have modules on DLs [3, 4]. This and others recent studies [1, 2, 5] show there is a pressing need for educators to explore the specific question of what should be the standard framework for DLE in LIS to ensure that students and their employers – can be assured of having an adequate skill set to work confidently and productively in this area. DLE taught in a Computer Science environment benefits from an outline framework from CC2001 but no such framework has yet been promulgated from LIS based programmes [1, 2]

Digital Library Education: Some International Course Structure Comparisons

Following our recent review of progress in Digital Library (DL) education [1], we present here a brief overview of current work to investigate the commonality/diversity of course structure between ten institutions outside North America which offer DL education in their library schools. The weighting of specifically DL module topic credits as a proportion of the overall course taught credits varies between 13% and 63%, and coverage of a proposed core topic set [2] is as high as 85%

A framework for analyzing both linkage and association: An analysis of Genetic Analysis Workshop 16 simulated data

We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, and association only tests under this framework. We also compared these results with variance-component linkage analysis and regression analyses. The results indicate that the method shows some promise, but finding genes that have very small (<0.1%) contributions to trait variance may require additional sources of information. All methods examined fared poorly for the smallest in the simulated "polygene" range (h(2 )of 0.0015 to 0.0002)

A phase II study of weekly neoadjuvant chemotherapy followed by radical chemoradiation for locally advanced cervical cancer

Background: We investigated the feasibility of dose-dense neoadjuvant chemotherapy (NACT) with paclitaxel and carboplatin before radical chemoradiation (CRT) and assessed the response rate to such a regimen. Methods: CxII is a single-arm phase II trial of 46 patients, with locally advanced cervical cancer (stage Ib2-IVa). Patients received dose-dense carboplatin (AUC2) and paclitaxel (80 mg m−2) weekly for six cycles followed by CRT (40 mg m−2 of weekly cisplatin, 50.4 Gy, 28 fractions plus brachytherapy). The primary end point was response rate 12 weeks post-CRT. Results: Baseline characteristics were: median age at diagnosis 43 years; 72% squamous, 22% adenocarcinoma and 7% adenosquamous histologies; FIGO stage IB2 (11%), II (50%), III (33%), IV (7%). Complete or partial response rate was 70% (95% CI: 54–82) post-NACT and 85% (95% CI: 71–94) post-CRT. The median follow-up was 39.1 months. Overall and progression-free survivals at 3 years were 67% (95% CI: 51–79) and 68% (95% CI: 51–79), respectively. Grade 3/4 toxicities were 20% during NACT (11% haematological, 9% non-haematological) and 52% during CRT (haematological: 41%, non-haematological: 22%). Conclusion: A good response rate is achieved by dose-dense weekly NACT with carboplatin and paclitaxel followed by radical CRT. This treatment regimen is feasible as evidenced by the acceptable toxicity of NACT and by the high compliance to radiotherapy (98%)

Transgenes in Mexican maize: molecular evidence and methodological considerations for GMO detection in landrace populations

A possible consequence of planting genetically modified organisms (GMOs) in centres of crop origin is unintended gene flow into traditional landraces. In 2001, a study reported the presence of the transgenic 35S promoter in maize landraces sampled in 2000 from the Sierra Juarez of Oaxaca, Mexico. Analysis of a large sample taken from the same region in 2003 and 2004 could not confirm the existence of transgenes, thereby casting doubt on the earlier results. These two studies were based on different sampling and analytical procedures and are thus hard to compare. Here, we present new molecular data for this region that confirm the presence of transgenes in three of 23 localities sampled in 2001. Transgene sequences were not detected in samples taken in 2002 from nine localities, while directed samples taken in 2004 from two of the positive 2001 localities were again found to contain transgenic sequences. These findings suggest the persistence or re-introduction of transgenes up until 2004 in this area. We address variability in recombinant sequence detection by analyzing the consistency of current molecular assays. We also present theoretical results on the limitations of estimating the probability of transgene detection in samples taken from landraces. The inclusion of a limited number of female gametes and, more importantly, aggregated transgene distributions may significantly lower detection probabilities. Our analytical and sampling considerations help explain discrepancies among different detection efforts, including the one presented here, and provide considerations for the establishment of monitoring protocols to detect the presence of transgenes among structured populations of landraces

Epigenetic liquid biopsies for minimal residual disease, what’s around the corner?

Liquid biopsy assays for minimal residual disease (MRD) are used to monitor and inform oncological treatment and predict the risk of relapse in cancer patients. To-date, most MRD assay development has focused on targeting somatic mutations. However, epigenetic changes are more frequent and universal than genetic alterations in cancer and circulating tumor DNA (ctDNA) retains much of these changes. Here, we review the epigenetic signals that can be used to detect MRD, including DNA methylation alterations and fragmentation patterns that differentiate ctDNA from noncancerous circulating cell-free DNA (ccfDNA). We then summarize the current state of MRD monitoring; highlight the advantages of epigenetics over genetics-based approaches; and discuss the emerging paradigm of assaying both genetic and epigenetic targets to monitor treatment response, detect disease recurrence, and inform adjuvant therapy

Biological measurement beyond the quantum limit

Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the specimen. By using non-classically correlated light, we demonstrated that the quantum limit can be surpassed in biological measurements. Quantum enhanced microrheology was performed within yeast cells by tracking naturally occurring lipid granules with sensitivity 2.4 dB beyond the quantum noise limit. The viscoelastic properties of the cytoplasm could thereby be determined with a 64% improved measurement rate. This demonstration paves the way to apply quantum resources broadly in a biological context