Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells

Scope The physiological relevance of contemporary cell culture studies is often perplexing, given the use of unmetabolized phytochemicals at supraphysiological concentrations. We investigated the activity of physiologically relevant anthocyanin metabolite signatures, derived from a previous pharmacokinetics study of 500 mg 13C5-cyanidin-3-glucoside in 8 healthy participants, on soluble vascular adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in human endothelial cells. Methods and results Signatures of peak metabolites (previously identified at 1, 6 and 24 h post-bolus) were reproduced using pure standards and effects were investigated across concentrations ten-fold lower and higher than observed mean (<5 μM) serum levels. Tumor necrosis factor-α (TNF-α)-stimulated VCAM-1 was reduced in response to all treatments, with maximal effects observed for the 6 h and 24 h profiles. Profiles tested at ten-fold below mean serum concentrations (0.19-0.44 μM) remained active. IL-6 was reduced in response to 1, 6 and 24 h profiles, with maximal effects observed for 6 h and 24 h profiles at concentrations above 2 μM. Protein responses were reflected by reductions in VCAM-1 and IL-6 mRNA, however there was no effect on phosphorylated NFκB-p65 expression. Conclusion Signatures of anthocyanin metabolites following dietary consumption reduce VCAM-1 and IL-6 production, providing evidence of physiologically relevant biological activity

Phase structure of a two-fluid bosonic system

The phase diagram of a two-fluid bosonic system is investigated. The proton-neutron interacting boson model (IBM-2) possesses a rich phase structure involving three control parameters and multiple order parameters. The surfaces of quantum phase transition between spherical, axially-symmetric deformed, and SU*(3) triaxial phases are determined, and the evolution of classical equilibrium properties across these transitions is investigated. Spectroscopic observables are considered in relation to the phase diagram.Comment: LaTeX (elsart), 46 pages, as published in Ann. Phys. (N.Y.

Forced oscillations in a hydrodynamical accretion disk and QPOs

This is the second of a series of papers aimed to look for an explanation on the generation of high frequency quasi-periodic oscillations (QPOs) in accretion disks around neutron star, black hole, and white dwarf binaries. The model is inspired by the general idea of a resonance mechanism in the accretion disk oscillations as was already pointed out by Abramowicz & Klu{\'z}niak (\cite{Abramowicz2001}). In a first paper (P\'etri \cite{Petri2005a}, paper I), we showed that a rotating misaligned magnetic field of a neutron star gives rise to some resonances close to the inner edge of the accretion disk. In this second paper, we suggest that this process does also exist for an asymmetry in the gravitational potential of the compact object. We prove that the same physics applies, at least in the linear stage of the response to the disturbance in the system. This kind of asymmetry is well suited for neutron stars or white dwarfs possessing an inhomogeneous interior allowing for a deviation from a perfectly spherically symmetric gravitational field. We show by a linear analysis that the disk initially in a cylindrically symmetric stationary state is subject to three kinds of resonances: a corotation resonance, a Lindblad resonance due to a driven force and a parametric sonance. The highest kHz QPOs are then interpreted as the orbital frequency of the disk at locations where the response to the resonances are maximal. It is also found that strong gravity is not required to excite the resonances.Comment: Accepte

Women’s views about management and cause of urinary tract infection: qualitative interview study

Objectives To explore the views of women with urinary tract infection on the acceptability of different strategies for managing the infection, including delayed use of antibiotics, and the cause of infection

Analytic descriptions for transitional nuclei near the critical point

Exact solutions of the Bohr Hamiltonian with a five-dimensional square well potential, in isolation or coupled to a fermion by the five-dimensional spin-orbit interaction, are considered as examples of a new class of dynamical symmetry or Bose-Fermi dynamical symmetry. The solutions provide baselines for experimental studies of even-even [E(5)] and odd-mass [E(5|4)] nuclei near the critical point of the spherical to deformed gamma-unstable phase transition.Comment: LaTeX (elsart), 53 pages; typographical correction to (3.15

Thin accretion disc with a corona in a central magnetic field

We study the steady-state structure of an accretion disc with a corona surrounding a central, rotating, magnetized star. We assume that the magneto-rotational instability is the dominant mechanism of angular momentum transport inside the disc and is responsible for producing magnetic tubes above the disc. In our model, a fraction of the dissipated energy inside the disc is transported to the corona via these magnetic tubes. This energy exchange from the disc to the corona which depends on the disc physical properties is modified because of the magnetic interaction between the stellar magnetic field and the accretion disc. According to our fully analytical solutions for such a system, the existence of a corona not only increases the surface density but reduces the temperature of the accretion disc. Also, the presence of a corona enhances the ratio of gas pressure to the total pressure. Our solutions show that when the strength of the magnetic field of the central neutron star is large or the star is rotating fast enough, profiles of the physical variables of the disc significantly modify due to the existence of a corona.Comment: Accepted for publication in Astrophysics & Space Scienc

Investigation of Some Physical Properties of Accretion Induced Collapse in Producing Millisecond Pulsars

We investigate some physical characteristics of Millisecond Pulsar (MSP) such as magnetic fields, spin periods and masses, that are produced by Accretion Induced Collapse (AIC) of an accreting white dwarf (WD) in stellar binary systems. We also investigate the changes of these characteristics during the mass-transfer phase of the system in its way to become a MSP. Our approach allows us to follow the changes in magnetic fields and spin periods during the conversion of WDs to MSPs via AIC process. We focus our attention mainly on the massive binary WDs (M > 1.0Msun) forming cataclysmic variables, that could potentially evolve to reach Chandrasekhar limit, thereafter they collapse and become MSPs. Knowledge about these parameters might be useful for further modeling of the observed features of AIC.Comment: 9 Pages, 4 figure

States and transitions in black-hole binaries

With the availability of the large database of black-hole transients from the Rossi X-Ray Timing Explorer, the observed phenomenology has become very complex. The original classification of the properties of these systems in a series of static states sorted by mass accretion rate proved not to be able to encompass the new picture. I outline here a summary of the current situation and show that a coherent picture emerges when simple properties such as X-ray spectral hardness and fractional variability are considered. In particular, fast transition in the properties of the fast time variability appear to be crucial to describe the evolution of black-hole transients. Based on this picture, I present a state-classification which takes into account the observed transitions. I show that, in addition to transients systems, other black-hole binaries and Active Galactic Nuclei can be interpreted within this framework. The association between these states and the physics of the accretion flow around black holes will be possible only through modeling of the full time evolution of galactic transient systems.Comment: 30 pages, 11 figures, To appear in Belloni, T. (ed.): The Jet Paradigm - From Microquasars to Quasars, Lect. Notes Phys. 794 (2009

Aquatic food security:insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment

Fisheries and aquaculture production, imports, exports and equitability of distribution determine the supply of aquatic food to people. Aquatic food security is achieved when a food supply is sufficient, safe, sustainable, shockproof and sound: sufficient, to meet needs and preferences of people; safe, to provide nutritional benefit while posing minimal health risks; sustainable, to provide food now and for future generations; shock-proof, to provide resilience to shocks in production systems and supply chains; and sound, to meet legal and ethical standards for welfare of animals, people and environment. Here, we present an integrated assessment of these elements of the aquatic food system in the United Kingdom, a system linked to dynamic global networks of producers, processors and markets. Our assessment addresses sufficiency of supply from aquaculture, fisheries and trade; safety of supply given biological, chemical and radiation hazards; social, economic and environmental sustainability of production systems and supply chains; system resilience to social, economic and environmental shocks; welfare of fish, people and environment; and the authenticity of food. Conventionally, these aspects of the food system are not assessed collectively, so information supporting our assessment is widely dispersed. Our assessment reveals trade-offs and challenges in the food system that are easily overlooked in sectoral analyses of fisheries, aquaculture, health, medicine, human and fish welfare, safety and environment. We highlight potential benefits of an integrated, systematic and ongoing process to assess security of the aquatic food system and to predict impacts of social, economic and environmental change on food supply and demand

Signals for Lorentz Violation in Electrodynamics

An investigation is performed of the Lorentz-violating electrodynamics extracted from the renormalizable sector of the general Lorentz- and CPT-violating standard-model extension. Among the unconventional properties of radiation arising from Lorentz violation is birefringence of the vacuum. Limits on the dispersion of light produced by galactic and extragalactic objects provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in the photon sector. The comparative spectral polarimetry of light from cosmologically distant sources yields stringent constraints of 2 x 10^{-32}. All remaining coefficients in the photon sector are measurable in high-sensitivity tests involving cavity-stabilized oscillators. Experimental configurations in Earth- and space-based laboratories are considered that involve optical or microwave cavities and that could be implemented using existing technology.Comment: 23 pages REVTe