1,768 research outputs found
Calculation and control of free divalent cations in solutions used for membrane fusion studies
Lack of fractalkine receptor on macrophages impairs spontaneous recovery of ribbon synapses after moderate noise trauma in C57BL/6 mice
Cosmic ray tests of the D0 preshower detector
The D0 preshower detector consists of scintillator strips with embedded
wavelength-shifting fibers, and a readout using Visible Light Photon Counters.
The response to minimum ionizing particles has been tested with cosmic ray
muons. We report results on the gain calibration and light-yield distributions.
The spatial resolution is investigated taking into account the light sharing
between strips, the effects of multiple scattering and various systematic
uncertainties. The detection efficiency and noise contamination are also
investigated.Comment: 27 pages, 24 figures, submitted to NIM
The transcriptome of utricle hair cell regeneration in the avian inner ear
Sensory hair cell loss is the major cause of hearing and balance disorders. Mammals are incapable of sustained hair cell regeneration, but lower vertebrates can regenerate these mechano-electrical transducers. We present the first comprehensive transcriptome (by mRNA-Seq) of hair cell regeneration in the chick utricle. We provide pathway and pattern annotations and correlate these with the phenotypic events that occur during regeneration. These patterns are surprisingly synchronous and highly punctuated. We show how these patterns are a new resource for identifying components of the hair cell transcriptome and identify 494 new putative hair-cell-specific genes and validate three of these (of three tested) by immunohistochemical staining. We describe many surprising new components and dynamic expression patterns, particularly within NOTCH signaling. For example, we show that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the expression of HES5. Likewise, the expression of ATOH1 is closely correlated with HEYL and the HLH inhibitory transcription factors ID1, ID2, and ID4. We investigate the correlation between fibroblast growth factor signaling and supporting cell proliferation and show that FGF20 inhibits supporting cell proliferation. We also present an analysis of 212 differentially expressed transcription factor genes in the regenerative time course that fall into nine distinct gene expression patterns, many of which correlate with phenotypic events during regeneration and represent attractive candidates for future analysis and manipulation of the regenerative program in sensory epithelia and other vertebrate neuroepithelia
Limits on Anomalous WWgamma and WWZ Couplings
Limits on the anomalous WWgamma and WWZ couplings are presented from a
simultaneous fit to the data samples of three gauge boson pair final states in
pbar-p collisions at sqrt(s)=1.8 TeV: Wgamma production with the W boson
decaying to enu or munu, W boson pair production with both of the W bosons
decaying to enu or munu, and WW or WZ production with one W boson decaying to
enu and the other W boson or the Z boson decaying to two jets. Assuming
identical WWgamma and WWZ couplings, 95 % C.L. limits on the anomalous
couplings of -0.30<Delta kappa<0.43 (lambda = 0) and -0.20<lambda<0.20 (Delta
kappa = 0) are obtained using a form factor scale Lambda = 2.0 TeV. Limits
found under other assumptions on the relationship between the WWgamma and WWZ
couplings are also presented.Comment: 13 pages, 3 figures, submitted to Physical Review
Second Generation Leptoquark Search in p\bar{p} Collisions at = 1.8 TeV
We report on a search for second generation leptoquarks with the D\O\
detector at the Fermilab Tevatron collider at = 1.8 TeV.
This search is based on 12.7 pb of data. Second generation leptoquarks
are assumed to be produced in pairs and to decay into a muon and quark with
branching ratio or to neutrino and quark with branching ratio
. We obtain cross section times branching ratio limits as a function
of leptoquark mass and set a lower limit on the leptoquark mass of 111
GeV/c for and 89 GeV/c for at the 95%\
confidence level.Comment: 18 pages, FERMILAB-PUB-95/185-
Jet Production via Strongly-Interacting Color-Singlet Exchange in Collisions
A study of the particle multiplicity between jets with large rapidity
separation has been performed using the D{\O}detector at the Fermilab Tevatron
Collider operating at TeV. A significant excess of
low-multiplicity events is observed above the expectation for color-exchange
processes. The measured fractional excess is , which is consistent with a strongly-interacting
color-singlet (colorless) exchange process and cannot be explained by
electroweak exchange alone. A lower limit of 0.80% (95% C.L.) is obtained on
the fraction of dijet events with color-singlet exchange, independent of the
rapidity gap survival probability.Comment: 15 pages (REVTeX), 3 PS figs (uuencoded/tar compressed, epsf.sty)
Complete postscript available at http://d0sgi0.fnal.gov/d0pubs/journals.html
Submitted to Physical Review Letter
Observation of ZZ production in ppbar collisions at sqrt(s) = 1.96 TeV
We present an observation for ZZ -> l+l-l'+l'- (l, l' = e or mu) production
in ppbar collisions at a center-of-mass energy of sqrt(s) = 1.96 TeV. Using 1.7
fb-1 of data collected by the D0 experiment at the Fermilab Tevatron Collider,
we observe three candidate events with an expected background of 0.14 +0.03
-0.02 events. The significance of this observation is 5.3 standard deviations.
The combination of D0 results in this channel, as well as in ZZ -> l+l-nunubar,
yields a significance of 5.7 standard deviations and a combined cross section
of sigma(ZZ) = 1.60 +/- 0.63 (stat.) +0.16 -0.17 (syst.) pb.Comment: 7 pages, 1 figure, 2 tables Modified slightly following review
proces
A search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology at sqrt(s) = 1.96 TeV
We report a search for the standard model Higgs boson in the missing energy
and acoplanar b-jet topology, using an integrated luminosity of 0.93 inverse
femtobarn recorded by the D0 detector at the Fermilab Tevatron Collider. The
analysis includes signal contributions from pp->ZH->nu nu b b, as well as from
WH production in which the charged lepton from the W boson decay is undetected.
Neural networks are used to separate signal from background. In the absence of
a signal, we set limits on the cross section of pp->VH times the branching
ratio of H->bb at the 95% C.L. of 2.6 - 2.3 pb, for Higgs boson masses in the
range 105 - 135 GeV, where V=W,Z. The corresponding expected limits range from
2.8 pb - 2.0 pb.Comment: Submitted to Phys. Rev. Letter
Measurement of the Boson Mass
A measurement of the mass of the boson is presented based on a sample of
5982 decays observed in collisions at
= 1.8~TeV with the D\O\ detector during the 1992--1993 run. From a
fit to the transverse mass spectrum, combined with measurements of the
boson mass, the boson mass is measured to be .Comment: 12 pages, LaTex, style Revtex, including 3 postscript figures
(submitted to PRL
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