A Cross-project Defect Prediction Model Using Feature Transfer and Ensemble Learning

Cross-project defect prediction (CPDP) trains the prediction models with existing data from other projects (the source projects) and uses the trained model to predict the target projects. To solve two major problems in CPDP, namely, variability in data distribution and class imbalance, in this paper we raise a CPDP model combining feature transfer and ensemble learning, with two stages of feature transfer and the classification. The feature transfer method is based on Pearson correlation coefficient, which reduces the dimension of feature space and the difference of feature distribution between items. The class imbalance is solved by SMOTE and Voting on both algorithm and data levels. The experimental results on 20 source-target projects show that our method can yield significant improvement on CPDP

Sudden death of entanglement with Hamiltonian ensemble assisted by auxiliary qubits

In this paper, we theoretically propose a method to simulate the longitudinal relaxation of a single qubit by coupling it to an auxiliary qubit. In order to mimic the finite-temperature relaxation, we utilize the Hamiltonian-ensemble approach [Kropf, Gneiting, and Buchleitner, Phys. Rev. X 6, 031023 (2016)] and in each realization the auxiliary qubit possesses a random level spacing. The longitudinal relaxation arises as a consequence of the ensemble average and the interaction between the working qubit and the auxiliary qubit. Furthermore, we apply this approach to investigate the influence of the longitudinal relaxation and the transverse relaxation on the entanglement dynamics of two qubits. It is discovered that the sudden death of the entanglement will occur as long as the longitudinal relaxation is present. The transverse relaxation assists the longitudinal relaxation and thus accelerates the finite-time disentanglement.Comment: 8 pages,7 figure

Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation

Transduction of extracellular matrix mechanics affects cell migration, proliferation, and differentiation. While this mechanotransduction is known to depend on the regulation of focal adhesion kinase phosphorylation on Y397 (FAKpY397), the mechanism remains elusive. To address this, we developed a mathematical model to test the hypothesis that FAKpY397-based mechanosensing arises from the dynamics of nanoscale integrin clustering, stiffness-dependent disassembly of integrin clusters, and FAKY397 phosphorylation within integrin clusters. Modeling results predicted that integrin clustering dynamics governs how cells convert substrate stiffness to FAKpY397, and hence governs how different cell types transduce mechanical signals. Existing experiments on MDCK cells and HT1080 cells, as well as our new experiments on 3T3 fibroblasts, confirmed our predictions and supported our model. Our results suggest a new pathway by which integrin clusters enable cells to calibrate responses to their mechanical microenvironment

Resolving the genetic paradox of invasions: Preadapted genomes and postintroduction hybridization of bigheaded carps in the Mississippi River Basin

The genetic paradox of biological invasions is complex and multifaceted. In particular, the relative role of disparate propagule sources and genetic adaptation through postintroduction hybridization has remained largely unexplored. To add resolution to this paradox, we investigate the genetic architecture responsible for the invasion of two invasive Asian carp species, bighead carp (Hypophthalmichthys nobilis) and silver carp (H. molitrix) (bigheaded carps) that experience extensive hybridization in the Mississippi River Basin (MRB). We sequenced the genomes of bighead and silver carps (~1.08G bp and ~1.15G bp, respectively) and their hybrids collected from the MRB. We found moderate‐to‐high heterozygosity in bighead (0.0021) and silver (0.0036) carps, detected significantly higher dN/dS ratios of single‐copy orthologous genes in bigheaded carps versus 10 other species of fish, and identified genes in both species potentially associated with environmental adaptation and other invasion‐related traits. Additionally, we observed a high genomic similarity (96.3% in all syntenic blocks) between bighead and silver carps and over 90% embryonic viability in their experimentally induced hybrids. Our results suggest intrinsic genomic features of bigheaded carps, likely associated with life history traits that presumably evolved within their native ranges, might have facilitated their initial establishment of invasion, whereas ex-situ interspecific hybridization between the carps might have promoted their range expansion. This study reveals an alternative mechanism that could resolve one of the genetic paradoxes in biological invasions and provides invaluable genomic resources for applied research involving bigheaded carps

Psychosocial interventions for suicidal and self-injurious-related behaviors among adolescents: a systematic review and meta-analysis of Chinese practices

BackgroundSuicidal and self-injurious-related behaviors (SSIRBs) are a serious public health challenge in China. However, a comprehensive systematic review of psychosocial interventions for SSIRBs among Chinese adolescents has not been performed. To fill this gap, this systematic review and meta-analysis aimed to examine psychosocial interventions for SSIRBs among Chinese adolescents.MethodsEight international (PubMed, EMBASE, Cochrane Library, ScienceDirect, Clinical Trial, CINAHL, PsycINFO, and Web of Science) and four Chinese (Wanfang, SinoMed, CEPS, and CNKI) databases were searched from inception to 31 January 2023. Data extraction and quality assessment were independently conducted by two groups of researchers. Qualitative synthesis and meta-analysis were both used.ResultsThe initial search yielded 16,872 titles. Of the 649 full texts reviewed, 19 intervention articles focusing on SSIRBs met the inclusion criteria. Thirteen out of the 19 included studies involved cognitive–behavioral therapy (CBT). Seven non-suicidal self-injury (NSSI) studies assessing self-injurious behaviors were included (six short-term studies and three long-term studies). Compared with long-term interventions [−1.30 (95% CI: –1.84, −0.76)], short-term psychosocial interventions had a higher standardized mean difference (SMD) value [1.86 (95% CI: –2.72, −0.99)]. Meta-regression showed an inverse relationship between the treatment response and sample size (slope = 0.068, Z = 2.914, p = 0.004) and proportion of females (slope = 1.096, Z = 5.848, p < 0.001). Subgroup analyses showed that compared with the “less than 1 month” group [−0.494 (−0.783, −0.205)], in the “immediate postintervention” group, the pooled estimate was significantly lower [−2.800 (−4.050, −1.550), p < 0.001].ConclusionOur review systematically summarized the key characteristics and effectiveness of existing psychosocial interventions for SSIRBs among Chinese adolescents. Short-term psychosocial interventions for NSSI were significantly effective in reducing self-injurious behavior scores, especially in the immediate postintervention period. More favorable treatment responses could be observed in both male and small samples

Exploring the risk factors of early sepsis after liver transplantation: development of a novel predictive model

BackgroundSepsis is a severe and common complication of liver transplantation (LT) with a high risk of mortality. However, effective tools for evaluating its risk factors are lacking. Therefore, this study identified the risk factors of early post-liver transplantation sepsis and established a nomogram.MethodsWe analyzed the risk factors of post-liver transplantation sepsis in 195 patients. Patients with infection and a systemic inflammatory response syndrome (SIRS) score ≥ 2 were diagnosed with sepsis. The predictive indicators were screened with the least absolute shrinkage and selection operator (LASSO) and collinearity analyses to develop a nomogram. The prediction performance of the new nomogram model, Sequential Organ Failure Assessment (SOFA) score, and Modified Early Warning Score (MEWS) was compared through assessment of the area under the curve (AUC), decision curve analysis (DCA), net reclassification index (NRI), and integrated discrimination improvement (IDI).ResultsThe nomogram was based on postoperative heart rate, creatinine concentration, PaO2/FiO2 ratio < 400 mmHg, blood glucose concentration, and international normalized ratio. The AUC of the nomogram, the SOFA score, and MEWS were 0.782 (95% confidence interval CI: 0.716–0.847), 0.649 (95% CI: 0.571–0.727), and 0.541 (95% CI: 0.469–0.614), respectively. The DCA curves showed that the net benefit rate of the nomogram was higher than that of the SOFA score and MEWS. The NRI and IDI tests revealed better predictive performance for the nomogram than SOFA score and MEWS.ConclusionHeart rate, creatinine concentration, PaO2/FiO2, glucose concentration, and international normalized ratio should be monitored postoperatively for patients at risk of post-liver transplantation sepsis. The nomogram based on the aforementioned risk factors had a better predictive performance than SOFA score and MEWS

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis study in which we assessed whether these two loci are also associated with myopia in other populations. The study population comprised 31 cohorts from the Consortium of Refractive Error and Myopia (CREAM) representing 4 different continents with 55,177 individuals; 42,845 Caucasians and 12,332 Asians. We performed a meta-analysis of 14 single nucleotide polymorphisms (SNPs) on 15q14 and 5 SNPs on 15q25 using linear regression analysis with spherical equivalent as a quantitative outcome, adjusted for age and sex. We calculated the odds ratio (OR) of myopia versus hyperopia for carriers of the top-SNP alleles using a fixed effects meta-analysis. At locus 15q14, all SNPs were significantly replicated, with the lowest P value 3.87 × 10 -12 for SNP rs634990 in Caucasians, and 9.65 × 10 -4 for rs8032019 in Asians. The overall meta-analysis provided P value 9.20 × 10 -23 for the top SNP rs634990. The risk of myopia versus hyperopia was OR 1.88 (95 % CI 1.64, 2.16, P < 0.001) for homozygous carriers of the risk allele at the top SNP rs634990, and OR 1.33 (95 % CI 1.19, 1.49, P < 0.001) for heterozygous carriers. SNPs at locus 15q25 did not replicate significantly (P value 5.81 × 10 -2 for top SNP rs939661). We conclude that common variants at chromosome 15q14 influence susceptibility for myopia in Caucasian and Asian populations world-wide. © The Author(s) 2012

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia : The CREAM Consortium

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E-08) and 2.3% (P = 6.9E-21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4; P = 6.3E-04).Peer reviewe

Financial reforms, divided interests, and tipping point policy-making : renminbi internationalization as a new catalyst for structural reforms in China

China’s RMB has been making quiet march onto the world stage, first into focus in the aftermath of the 2008 financial crisis, and notably gathering pace after 2012. By examining the seeming puzzle of why RMB internationalization, after a long albeit methodical trudge, accelerated after 2012, this paper seeks to offer a theory that could explain the motivations behind China’s pursuit of RMB internationalization. I argue that the existing approaches to this question, which primarily looks to the traditional economic factors such as relative national economic fundamentals, cost/benefit of currency internationalization, and impact of external shocks, fall short of explaining the timing, pace and trajectory of the RMB internationalization process. I maintain instead that the source of the dynamics driving RMB internationalization should be located in the structure of political decision making and political imperatives of the key players in the decision making process. This paper contends that RMB internationalization should above all be viewed in the broad context of China’s next round of reforms that centers on liberalizing the financial sector and developing the capital markets. Putting Chinese political decision making in the perspective of fragmented authoritarianism, this paper argues that with the balance of power of interest group coalitions favoring status quo or change in a deadlock, a lever is needed to break the stalemate and tip the balance toward reforms. Recognizing the need for financial reforms as China increasingly reaches the limit of its export-led growth model, political entrepreneurs at PBOC, under the personal leadership of Governor Zhou Xiaochuan and buttressed by the superior institutional resources and capacity, promoted RMB internationalization as the key lever to redistribute incentives and realign underlying coalitions. Capitalizing on favorable changes at the party’s top taking place post the power transition, which brought about a degree of centralization of the financial policy decision making that wasn’t available previously, Zhou Xiaochuan and his fellow political entrepreneurs were able to push forward RMB internationalization more effectively that both exposed the need for further financial sector reforms and generated broader support to tip the balance of power toward reforms.Arts, Faculty ofPolitical Science, Department ofGraduat