Driving two atoms in an optical cavity into an entangled steady state using engineered decay

We propose various schemes for the dissipative preparation of a maximally entangled steady state of two atoms in an optical cavity. Harnessing the natural decay processes of cavity photon loss and spontaneous emission, we use an effective operator formalism to identify and engineer effective decay processes, which reach an entangled steady state of two atoms as the unique fixed point of the dissipative time evolution. We investigate various aspects that are crucial for the experimental implementation of our schemes in present-day and future cavity quantum electrodynamics systems and analytically derive the optimal parameters, the error scaling and the speed of convergence of our protocols. Our study shows promising performance of our schemes for existing cavity experiments and favorable scaling of fidelity and speed with respect to the cavity parameters.Comment: 37 pages, 14 figure

Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines

We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that proton bonding can block some non radiative processes present in the monomer.Comment: We acknowledge the use of the computing facility cluster GMPCS of the LUMAT federation (FR LUMAT 2764

Subcellular Localization of SUN2 Is Regulated by Lamin A and Rab5

SUN2 is an inner nuclear membrane protein with a conserved Sad1/UNC-84 homology SUN-domain at the C-terminus. Intriguingly, SUN2 has also been reported to interact with Rab5, which localizes in early endosomes. To clarify the dual subcellular localization of SUN2, we investigated its localization in lamin A/C deficient cells rescued with lamin A or lamin C isoform, and in HeLa cells transfected with Rab5 or its mutants. We found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2. SUN2 was redistributed to endosomes upon overexpression of Rab5, but remained on the nuclear envelope when the SUN domain was deleted. To explore the physiological function of SUN2 in vesicle trafficking and endocytosis, we demonstrated the colocalization of endogenous SUN2 and Rab5. Moreover, overexpression of SUN2 stimulated the uptake of transferrin while suppression of SUN2 expression attenuated the process. These findings support a role of SUN2 in endocytosis

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis

Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C. novyi α-toxin (TcnA) are important pathogenicity factors, which represent the family of the clostridial glucosylating toxins (CGTs). Toxin A and B are associated with antibiotic-associated diarrhea and pseudomembraneous colitis. Lethal toxin is involved in toxic shock syndrome after abortion and α-toxin in gas gangrene development. CGTs enter cells via receptor-mediated endocytosis and require an acidified endosome for translocation of the catalytic domain into the cytosol. Here we studied the endocytic processes that mediate cell internalization of the CGTs. Intoxication of cells was monitored by analyzing cell morphology, status of Rac glucosylation in cell lysates and transepithelial resistance of cell monolayers. We found that the intoxication of cultured cells by CGTs was strongly delayed when cells were preincubated with dynasore, a cell-permeable inhibitor of dynamin, or chlorpromazine, an inhibitor of the clathrin-dependent endocytic pathway. Additional evidence about the role of clathrin in the uptake of the prototypical CGT family member toxin B was achieved by expression of a dominant-negative inhibitor of the clathrin-mediated endocytosis (Eps15 DN) or by siRNA against the clathrin heavy chain. Accordingly, cells that expressed dominant-negative caveolin-1 were not protected from toxin B-induced cell rounding. In addition, lipid rafts impairment by exogenous depletion of sphingomyelin did not decelerate intoxication of HeLa cells by CGTs. Taken together, our data indicate that the endocytic uptake of the CGTs involves a dynamin-dependent process that is mainly governed by clathrin

MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes

Objective: Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. We sought to: (1) evaluate radiomics to assess brain structural integrity by predicting white matter hyperintensities burdens (WMH) and (2) uncover associations between predictive radiomic features and clinical phenotypes. Methods: We analyzed a multi-site cohort of 4,163 acute ischemic strokes (AIS) patients with T2-FLAIR MR images with total brain and WMH segmentations. Radiomic features were extracted from normal-appearing brain tissue (brain mask–WMH mask). Radiomics-based prediction of personalized WMH burden was done using ElasticNet linear regression. We built a radiomic signature of WMH with stable selected features predictive of WMH burden and then related this signature to clinical variables using canonical correlation analysis (CCA). Results: Radiomic features were predictive of WMH burden (R2 = 0.855 ± 0.011). Seven pairs of canonical variates (CV) significantly correlated the radiomics signature of WMH and clinical traits with respective canonical correlations of 0.81, 0.65, 0.42, 0.24, 0.20, 0.15, and 0.15 (FDR-corrected p-valuesCV1–6 < 0.001, p-valueCV7 = 0.012). The clinical CV1 was mainly influenced by age, CV2 by sex, CV3 by history of smoking and diabetes, CV4 by hypertension, CV5 by atrial fibrillation (AF) and diabetes, CV6 by coronary artery disease (CAD), and CV7 by CAD and diabetes. Conclusion: Radiomics extracted from T2-FLAIR images of AIS patients capture microstructural damage of the cerebral parenchyma and correlate with clinical phenotypes, suggesting different radiographical textural abnormalities per cardiovascular risk profile. Further research could evaluate radiomics to predict the progression of WMH and for the follow-up of stroke patients’ brain health

Euclid preparation. XXIV. Calibration of the halo mass function in Λ(ν)\Lambda(\nu)CDM cosmologies

Euclid's photometric galaxy cluster survey has the potential to be a very competitive cosmological probe. The main cosmological probe with observations of clusters is their number count, within which the halo mass function (HMF) is a key theoretical quantity. We present a new calibration of the analytic HMF, at the level of accuracy and precision required for the uncertainty in this quantity to be subdominant with respect to other sources of uncertainty in recovering cosmological parameters from Euclid cluster counts. Our model is calibrated against a suite of N-body simulations using a Bayesian approach taking into account systematic errors arising from numerical effects in the simulation. First, we test the convergence of HMF predictions from different N-body codes, by using initial conditions generated with different orders of Lagrangian Perturbation theory, and adopting different simulation box sizes and mass resolution. Then, we quantify the effect of using different halo-finder algorithms, and how the resulting differences propagate to the cosmological constraints. In order to trace the violation of universality in the HMF, we also analyse simulations based on initial conditions characterised by scale-free power spectra with different spectral indexes, assuming both Einstein--de Sitter and standard $\Lambda$CDM expansion histories. Based on these results, we construct a fitting function for the HMF that we demonstrate to be sub-percent accurate in reproducing results from 9 different variants of the $\Lambda$CDM model including massive neutrinos cosmologies. The calibration systematic uncertainty is largely sub-dominant with respect to the expected precision of future mass-observation relations; with the only notable exception of the effect due to the halo finder, that could lead to biased cosmological inference.Comment: 24 pages, 21 figures, 5 tables, 3 appendixes

Euclid preparation. XXIX. Water ice in spacecraft part I: The physics of ice formation and contamination

Molecular contamination is a well-known problem in space flight. Water is the most common contaminant and alters numerous properties of a cryogenic optical system. Too much ice means that Euclid's calibration requirements and science goals cannot be met. Euclid must then be thermally decontaminated, a long and risky process. We need to understand how iced optics affect the data and when a decontamination is required. This is essential to build adequate calibration and survey plans, yet a comprehensive analysis in the context of an astrophysical space survey has not been done before. In this paper we look at other spacecraft with well-documented outgassing records, and we review the formation of thin ice films. A mix of amorphous and crystalline ices is expected for Euclid. Their surface topography depends on the competing energetic needs of the substrate-water and the water-water interfaces, and is hard to predict with current theories. We illustrate that with scanning-tunnelling and atomic-force microscope images. Industrial tools exist to estimate contamination, and we must understand their uncertainties. We find considerable knowledge errors on the diffusion and sublimation coefficients, limiting the accuracy of these tools. We developed a water transport model to compute contamination rates in Euclid, and find general agreement with industry estimates. Tests of the Euclid flight hardware in space simulators did not pick up contamination signals; our in-flight calibrations observations will be much more sensitive. We must understand the link between the amount of ice on the optics and its effect on Euclid's data. Little research is available about this link, possibly because other spacecraft can decontaminate easily, quenching the need for a deeper understanding. In our second paper we quantify the various effects of iced optics on spectrophotometric data.Comment: 35 pages, 22 figures, A&A in press. Changes to previous version: language edits, added Z. Bolag as author in the arxiv PDF (was listed in the ASCII author list and in the journal PDF, but not in the arxiv PDF). This version is identical to the journal versio

Euclid preparation: XIII. Forecasts for galaxy morphology with the Euclid Survey using deep generative models

We present a machine learning framework to simulate realistic galaxies for the Euclid Survey, producing more complex and realistic galaxies than the analytical simulations currently used in Euclid. The proposed method combines a control on galaxy shape parameters offered by analytic models with realistic surface brightness distributions learned from real Hubble Space Telescope observations by deep generative models. We simulate a galaxy field of 0.4 deg2 as it will be seen by the Euclid visible imager VIS, and we show that galaxy structural parameters are recovered to an accuracy similar to that for pure analytic Sérsic profiles. Based on these simulations, we estimate that the Euclid Wide Survey (EWS) will be able to resolve the internal morphological structure of galaxies down to a surface brightness of 22.5 mag arcsec-2, and the Euclid Deep Survey (EDS) down to 24.9 mag arcsec-2. This corresponds to approximately 250 million galaxies at the end of the mission and a 50% complete sample for stellar masses above 1010.6 M (resp. 109.6 M) at a redshift z ∼ 0.5 for the EWS (resp. EDS). The approach presented in this work can contribute to improving the preparation of future high-precision cosmological imaging surveys by allowing simulations to incorporate more realistic galaxies

Euclid Preparation. XXVIII. Forecasts for ten different higher-order weak lensing statistics

Recent cosmic shear studies have shown that higher-order statistics (HOS) developed by independent teams now outperform standard two-point estimators in terms of statistical precision thanks to their sensitivity to the non-Gaussian features of large-scale structure. The aim of the Higher-Order Weak Lensing Statistics (HOWLS) project is to assess, compare, and combine the constraining power of ten different HOS on a common set of $Euclid$-like mocks, derived from N-body simulations. In this first paper of the HOWLS series, we computed the nontomographic ($\Omega_{\rm m}$, $\sigma_8$) Fisher information for the one-point probability distribution function, peak counts, Minkowski functionals, Betti numbers, persistent homology Betti numbers and heatmap, and scattering transform coefficients, and we compare them to the shear and convergence two-point correlation functions in the absence of any systematic bias. We also include forecasts for three implementations of higher-order moments, but these cannot be robustly interpreted as the Gaussian likelihood assumption breaks down for these statistics. Taken individually, we find that each HOS outperforms the two-point statistics by a factor of around two in the precision of the forecasts with some variations across statistics and cosmological parameters. When combining all the HOS, this increases to a $4.5$ times improvement, highlighting the immense potential of HOS for cosmic shear cosmological analyses with $Euclid$. The data used in this analysis are publicly released with the paper.Comment: 33 pages, 24 figures, main results in Fig. 19 & Table 5, version published in A&

Euclid preparation: I. the Euclid Wide Survey

Euclid is a mission of the European Space Agency that is designed to constrain the properties of dark energy and gravity via weak gravitational lensing and galaxy clustering. It will carry out a wide area imaging and spectroscopy survey (the Euclid Wide Survey: EWS) in visible and near-infrared bands, covering approximately 15 000 deg2 of extragalactic sky in six years. The wide-field telescope and instruments are optimised for pristine point spread function and reduced stray light, producing very crisp images. This paper presents the building of the Euclid reference survey: The sequence of pointings of EWS, deep fields, and calibration fields, as well as spacecraft movements followed by Euclid as it operates in a step-And-stare mode from its orbit around the Lagrange point L2. Each EWS pointing has four dithered frames; we simulated the dither pattern at the pixel level to analyse the effective coverage. We used up-To-date models for the sky background to define the Euclid region-of-interest (RoI). The building of the reference survey is highly constrained from calibration cadences, spacecraft constraints, and background levels; synergies with ground-based coverage were also considered. Via purposely built software, we first generated a schedule for the calibrations and deep fields observations. On a second stage, the RoI was tiled and scheduled with EWS observations, using an algorithm optimised to prioritise the best sky areas, produce a compact coverage, and ensure thermal stability. The result is the optimised reference survey RSD-2021A, which fulfils all constraints and is a good proxy for the final solution. The current EWS covers ∼14.500 deg2. The limiting AB magnitudes (5ρpoint-like source) achieved in its footprint are estimated to be 26.2 (visible band IE) and 24.5 (for near infrared bands YE, JE, HE); for spectroscopy, the Hα line flux limit is 2.10-16 erg-1 cm-2 s-1 at 1600 nm; and for diffuse emission, the surface brightness limits are 29.8 (visible band) and 28.4 (near infrared bands) mag arcsec-2