Exact and Fast Numerical Algorithms for the Stochastic Wave Equation

On the basis of integral representations we propose fast numerical methods to solve the Cauchy problem for the stochastic wave equation without boundaries and with the Dirichlet boundary conditions. The algorithms are exact in a probabilistic sense

Carbon Free Boston: Transportation Technical Report

Part of a series of reports that includes: Carbon Free Boston: Summary Report; Carbon Free Boston: Social Equity Report; Carbon Free Boston: Technical Summary; Carbon Free Boston: Buildings Technical Report; Carbon Free Boston: Waste Technical Report; Carbon Free Boston: Energy Technical Report; Carbon Free Boston: Offsets Technical ReportOVERVIEW: Transportation connects Boston’s workers, residents and tourists to their livelihoods, health care, education, recreation, culture, and other aspects of life quality. In cities, transit access is a critical factor determining upward mobility. Yet many urban transportation systems, including Boston’s, underserve some populations along one or more of those dimensions. Boston has the opportunity and means to expand mobility access to all residents, and at the same time reduce GHG emissions from transportation. This requires the transformation of the automobile-centric system that is fueled predominantly by gasoline and diesel fuel. The near elimination of fossil fuels—combined with more transit, walking, and biking—will curtail air pollution and crashes, and dramatically reduce the public health impact of transportation. The City embarks on this transition from a position of strength. Boston is consistently ranked as one of the most walkable and bikeable cities in the nation, and one in three commuters already take public transportation. There are three general strategies to reaching a carbon-neutral transportation system: • Shift trips out of automobiles to transit, biking, and walking;1 • Reduce automobile trips via land use planning that encourages denser development and affordable housing in transit-rich neighborhoods; • Shift most automobiles, trucks, buses, and trains to zero-GHG electricity. Even with Boston’s strong transit foundation, a carbon-neutral transportation system requires a wholesale change in Boston’s transportation culture. Success depends on the intelligent adoption of new technologies, influencing behavior with strong, equitable, and clearly articulated planning and investment, and effective collaboration with state and regional partners.Published versio

Mary of Nemmegen: The ca. 1518 Translation and the Middle Dutch Analogue, Mariken van Nieumeghen

Mary of Nemmegen, a prose condensation in English of the Middle Dutch play Mariken van Nieumeghen, is an important example of the literature that was imported from Holland in the early part of the sixteenth century - literature that helped to establish an English taste for narrative prose fiction. It also may be compared to Everyman, described as a treatise in the manner of a moral play. Mary of Nemmegen is an analogue of the Faustus story, in which a person makes an agreement with the devil; hence the work deserves to be made available as background to Christopher Marlowe\u27s Tragical History of Doctor Faustus as well as to later redactions of the Faust story. As such, it is also a window on the obsession in its own time with the occult, including its relation to the issues of damnation and salvation. Further, because Mary is ultimately saved from damnation and becomes saintly, the story is related to the saint play tradition as exemplified by the Digby Mary Magdalene. The original Dutch drama itself has had a long history in various languages, appearing even in Arabic in the nineteenth century, and is regarded as the most important play of its type from the Dutch Renaissance. It remains a staple reading matter in Dutch education. Mary of Nemmegen: The ca. 1518 Translation and the Middle Dutch Analogue, Mariken van Nieumeghen presents in an old-spelling critical edition, with introduction and notes, along with the text and literal translation of the Dutch play.https://scholarworks.wmich.edu/mip_edam/1005/thumbnail.jp

The 2s atomic level in muonic 208-Pb

Relative intensities and energy measurements of 2s level in muonic Pb-20

ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations.

The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 μg/ml, 0.1 μg/ml or 1.0 μg/ml) were measured using the alkaline single-cell gel electrophoresis (comet) assay to measure DNA single-strand breaks (SSBs) and the cytokinesis-block micronucleus (CBMN) assay to determine micronucleus formation. Biochemical-cell signatures were also ascertained using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy. In the comet assay, organotin(IV) carboxylates induced significantly-elevated levels of DNA SSBs. Elevated micronucleus-forming activities were also observed. Following interrogation using ATR-FTIR spectroscopy, infrared spectra in the biomolecular range (900 cm-1 – 1800 cm-1) derived from organotin-treated MCF-7 cells exhibited clear alterations in their biochemical-cell fingerprint compared to control-cell populations following exposures as low as 0.0001 μg/ml. Mono-, di- or tri-organotin(IV) carboxylates (0.1 μg/ml, 1.0 μg/ml or 10.0 μg/ml) were markedly cytotoxic as determined by the clonogenic assay following treatment of MCF-7 cells with ≥ 1.0 μg/ml. Our results demonstrate that ATR-FTIR spectroscopy can be applied to detect molecular alterations induced by organotin(IV) compounds at sub-cytotoxic and sub-genotoxic concentrations. This biophysical approach points to a novel means of assessing risk associated with environmental contaminants

Modelling commuting catchments in Ireland: a hierarchical approach using GIS.

Over recent years there has emerged an increased awareness of the importance of strategic spatial planning and of the extent to which concepts such as place and space really matter (Faludi, 2000). An enhanced understanding of the geography of living and the economy requires not only a knowledge of where people and objects are but also of how those places relate to one another to create functional spaces. This requires fundamentally sound data on movement patterns, of which the most important is probably the daily journey to work (Horner, 1999, McCabe, 2006 Pers Comm). In this paper we examine spatial modelling approaches to commuting patterns using data from the CSO 2002 Census of Population (CSO 2003a, CSO 2003b. CSO 2004a). This is a particularly apposite time to undertake this research. A number of national strategic initiatives including the next Irish National Development Plan and the current National Spatial Strategy provide a clear policy context for the study (Morgenroth and Fitzgerald,2006). Additionally it is the specific intent of the CSO in providing this data set to stimulate geo-computational analysis and modelling. This research aims to map travel to work flows in 2002 from the 15% national anonymised individual sample (known as the POWSAR data set) and secondly to investigate the technical production of new Travel Catchments Areas (TCAs) for the state as a whole

Practical assessment of hardware limitations on power aware wireless sensor networks - An anti-windup approach

This work considers the effect of hardware constraints that typically arise in practical power-aware wireless sensor network systems. A rigorous methodology is presented that quantifies the effect of output power limit and quantization constraints on bit error rate performance. The approach uses a novel, intuitively appealing means of addressing the output power constraint, wherein the attendant saturation block is mapped from the output of the plant to its input and compensation is then achieved using a robust anti-windup scheme. A priori levels of system performance are attained using a quantitative feedback theory approach on the initial, linear stage of the design paradigm. This hybrid design is assessed experimentally using a fully compliant 802.15.4 testbed where mobility is introduced through the use of autonomous robots. A benchmark comparison between the new approach and a number of existing strategies is also presented

Adenosine Mapping for Adenosine‐Dependent Accessory Pathway Ablation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106956/1/pace12324.pd

Hepatitis C quasispecies adaptation in the setting of a variable fidelity polymerase

Hepatitis C (HCV) is a virus characterized by an RNA-dependent RNA polymerase that lacks a proofreading mechanism and, as a result, generates a quasispecies. There is emerging evidence that this RNA-dependent RNA polymerase may in fact have variable fidelity. Here, we review the relevant concepts, including fitness landscapes, clonal interference, robustness, selection, adaptation, mutation rates, and their optimization, and provide a unique interpretation of a number of relevant theoretical models, evolving the theory of replicative homeostasis in light of their findings. We suggest that a variable fidelity polymerase can find its own optimal mutation rate, which is governed by the sequence itself and certain population dynamics. We propose that this concept can explain features of viral kinetics and clearance, both spontaneously and following treatment of chronic HCV. We point to evidence that supports this theory and explain how it refines replicative homeostasis and conclude by discussing particular areas of potential research that might augment our understanding of viral host interactions at an individual cellular level