Deuxième Table Ronde : L'intégration bancaire européenne : Quelle stratégie pour les banques françaises ?

Cassou Pierre-Henri, Dard Guillaume, Lebègue Daniel, Simon Pierre, Sitruk Hervé, Walrafen Thierry. Deuxième Table Ronde : L'intégration bancaire européenne : Quelle stratégie pour les banques françaises ?. In: Revue d'économie financière, n°36, 1996. L’Union monétaire européenne. pp. 237-256

L'état de la coopération économique et financière internationale

de Boissieu Christian, Jacquet, Le Lorier Anne, Walrafen Thierry, Le Boucher Éric. L'état de la coopération économique et financière internationale. In: Revue d'économie financière, n°33, 1995. La coopération dans le système financier international. pp. 163-185

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) - the translocation defining a new T-ALL subtype in very young children.

The c-Myb transcription factor is essential for primitive and adult hematopoiesis, including in the T-cell lineage. The c-myb locus is a common site of retroviral insertional mutagenesis, however no recurrent genomic involvement has been reported in human malignancies. Here, we identified two types of genomic alterations involving the C-MYB locus at 6q23 in human T-cell acute leukemia (T-ALL). First, we found a reciprocal translocation, t(6;7)(q23;q34), that juxtaposed the TCRB and C-MYB loci (n=6 cases). Second, a genome wide copy-number analysis by array-CGH identified short somatic duplications which include C-MYB (MYB(dup), n=13 cases out of 84 T-ALL, 15%). Expression analysis, including allele-specific approaches, showed stronger C-MYB expression in the MYB-rearranged cases compared to other T-ALLs, and a dramatically skewed C-MYB allele expression in the TCRB-MYB cases which suggests that a translocation-driven deregulated expression may overcome a cellular attempt to downregulate C-MYB. Strikingly, profiling of the T-ALLs by clinical, genomic and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median 2.2 years-old) and with a proliferation/mitosis expression signature. By contrast, the MYB(dup) alteration was associated to the previously defined T-ALL subtypes

Extracting biomarkers of commitment to cancer development:potential role of vibrational spectroscopy in systems biology

The complex processes driving cancer have so far impeded the discovery of dichotomous biomarkers associated with its initiation and progression. Reductionist approaches utilizing ?omics? technologies have met some success in identifying molecular alterations associated with carcinogenesis. Systems biology is an emerging science that combines high-throughput investigation techniques to define the dynamic interplay between regulatory biological systems in response to internal and external cues. Vibrational spectroscopy has the potential to play an integral role within systems biology research approaches. It is capable of examining global models of carcinogenesis by scrutinizing chemical bond alterations within molecules. The application of infrared or Raman spectroscopic approaches coupled with computational analysis under the systems biology umbrella can assist the transition of biomarker research from the molecular level to the system level. The comprehensive representation of carcinogenesis as a multilevel biological process will inevitably revolutionize cancer-related healthcare by personalizing risk prediction and prevention