1,270 research outputs found
Home ground advantage - fact or fallacy? A comment on the 2004 Super 12 rugby competition
Objective. The aim of this study was to determine whether there was an advantage to playing at home in the 2004 Rugby Union Super 12 competition. The question was relevant because this unusual competition involved travelling across time zones during the competition, potentially negating any home ground advantage caused by fatigue from travel and changing time zones. Main outcome measure. The mean points difference (points for the team minus points against the team) for âhomeâ and âawayâ fixtures was calculated for each team before the semi-final stage of the competition. Result. Combined results for all 12 teams showed that the points difference was positive and significantly greater at âhomeâ than âawayâ fixtures (7.4 ± 6.9 points v. -7.4 ± 7.9 points, home v. away) (p < 0.05). Conclusions. The combined mean positive points difference at home indicates a home ground advantage, and that on average teams scored more points than their opposition when playing at home. This has implications for the âfairnessâ of the competition as 6 teams had 6 home matches whereas the other 6 teams had 5 home matches in the 2004 Super 12 competition
The ecomics of ecosystems and biodiversity: scoping the scale
The G8 decided in March 2007 to initiate a âReview on the economics of biodiversity lossâ, in the so called Potsdam Initiative: 'In a global study we will initiate the process of analysing the global economic benefit of biological diversity, the costs of the loss of biodiversity and the failure to take protective measures versus the costs of effective conservation. The study is being supported by the European Commission (together with the European Environmental Agency and in cooperation with the German Government. âThe objective of the current study is to provide a coherent overview of existing scientific knowledge upon which to base the economics of the Review, and to propose a coherent global programme of scientific work, both for Phase 2 (consolidation) and to enable more robust future iterations of the Review beyond 2010.
Faxen relations in solids - a generalized approach to particle motion in elasticity and viscoelasticity
A movable inclusion in an elastic material oscillates as a rigid body with
six degrees of freedom. Displacement/rotation and force/moment tensors which
express the motion of the inclusion in terms of the displacement and force at
arbitrary exterior points are introduced. Using reciprocity arguments two
general identities are derived relating these tensors. Applications of the
identities to spherical particles provide several new results, including simple
expressions for the force and moment on the particle due to plane wave
excitation.Comment: 11 pages, 4 figure
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. Enhancement of P2X7 receptor responses may be useful in pathogen clearance particularly in individuals with defective microbial killing mechanisms. Ginsenosides from Panax ginseng have been discovered to act as positive allosteric modulators of P2X7. Here we describe a novel modulator binding site identified by computational docking located in the central vestibule of P2X7 involving S60, D318, and L320 in the lower body ÎČ-sheets lining the lateral portals. Potentiation of ATP-mediated responses by ginsenosides CK and Rd caused enhanced ionic currents, Ca2+ influx and YOPRO-1 uptake in stably transfected HEK-293 cells (HEK-hP2X7) plus enhanced cell death responses. Potentiation of ATP responses by CK and Rd was markedly reduced by mutations S59A, S60A, D318L and L320A supporting the proposed allosteric modulator binding site. Furthermore, mutation of the conserved residues S60 and D318 led to alterations in P2X7 response and a higher sensitivity to ATP in the absence of modulators suggesting residues in the connecting rods play an important role in regulating P2X7 gating. Identification of this novel binding site location in the central vestibule may also be relevant for structurally similar channels
Unbound states of 32Cl and the 31S(p,\gamma)32Cl reaction rate
The 31S(p,\gamma)32Cl reaction is expected to provide the dominant break-out
path from the SiP cycle in novae and is important for understanding enrichments
of sulfur observed in some nova ejecta. We studied the 32S(3He,t)32Cl
charge-exchange reaction to determine properties of proton-unbound levels in
32Cl that have previously contributed significant uncertainties to the
31S(p,\gamma)32Cl reaction rate. Measured triton magnetic rigidities were used
to determine excitation energies in 32Cl. Proton-branching ratios were obtained
by detecting decay protons from unbound 32Cl states in coincidence with
tritons. An improved 31S(p,\gamma)32Cl reaction rate was calculated including
robust statistical and systematic uncertainties
Spotlight environmental sustainability: a strategic priority for NICE
This article provides the context for the ambition outlined in the the National Institute for Health and Care Excellence (NICE) 2021â2026 strategy to âlead globally on the potential to include environmental impact data in its guidance to reduce the carbon footprint of health and careâ. Anthropogenic environmental changes pose a catastrophic risk to human health, with potential to widen national and global health inequalities. Recognising the fact that NICE guidance influences the way health and care is delivered and its consequent environmental impact, NICE has included environmental sustainability among its strategic priorities. This article outlines the work underway to meet this sustainability agenda at NICE
A path-oriented encoding evolutionary algorithm for network coding resource minimization
Network coding is an emerging telecommunication technique, where any intermediate node is allowed to recombine incoming data if necessary. This technique helps to increase the throughput, however, very likely at the cost of huge amount of computational overhead, due to the packet recombination performed (ie coding operations). Hence, it is of practical importance to reduce coding operations while retaining the benefits that network coding brings to us. In this paper, we propose a novel evolutionary algorithm (EA) to minimize the amount of coding operations involved. Different from the state-of-the-art EAs which all use binary encodings for the problem, our EA is based on path-oriented encoding. In this new encoding scheme, each chromosome is represented by a union of paths originating from the source and terminating at one of the receivers. Employing path-oriented encoding leads to a search space where all solutions are feasible, which fundamentally facilitates more efficient search of EAs. Based on the new encoding, we develop three basic operators, that is, initialization, crossover and mutation. In addition, we design a local search operator to improve the solution quality and hence the performance of our EA. The simulation results demonstrate that our EA significantly outperforms the state-of-the-art algorithms in terms of global exploration and computational time
Scenarios and models for exploring future trends of biodiversity and ecosystem services changes. Final report to the European Commission, DG Environment on Contract
Attractiveness of periodic orbits in parametrically forced systemswith time-increasing friction
We consider dissipative one-dimensional systems subject to a periodic force
and study numerically how a time-varying friction affects the dynamics. As a
model system, particularly suited for numerical analysis, we investigate the
driven cubic oscillator in the presence of friction. We find that, if the
damping coefficient increases in time up to a final constant value, then the
basins of attraction of the leading resonances are larger than they would have
been if the coefficient had been fixed at that value since the beginning. From
a quantitative point of view, the scenario depends both on the final value and
the growth rate of the damping coefficient. The relevance of the results for
the spin-orbit model are discussed in some detail.Comment: 30 pages, 6 figure
Conservation of complete trimethylation of lysine-43 in the rotor ring of c-subunits of metazoan adenosine triphosphate (ATP) synthases.
The rotors of ATP synthases turn about 100 times every second. One essential component of the rotor is a ring of hydrophobic c-subunits in the membrane domain of the enzyme. The rotation of these c-rings is driven by a transmembrane proton-motive force, and they turn against a surface provided by another membrane protein, known as subunit a. Together, the rotating c-ring and the static subunit a provide a pathway for protons through the membrane in which the c-ring and subunit a are embedded. Vertebrate and invertebrate c-subunits are well conserved. In the structure of the bovine F1-ATPase-c-ring subcomplex, the 75 amino acid c-subunit is folded into two transmembrane α-helices linked by a short loop. Each bovine rotor-ring consists of eight c-subunits with the N- and C-terminal α-helices forming concentric inner and outer rings, with the loop regions exposed to the phospholipid head-group region on the matrix side of the inner membrane. Lysine-43 is in the loop region and its Δ-amino group is completely trimethylated. The role of this modification is unknown. If the trimethylated lysine-43 plays some important role in the functioning, assembly or degradation of the c-ring, it would be expected to persist throughout vertebrates and possibly invertebrates also. Therefore, we have carried out a proteomic analysis of c-subunits across representative species from different classes of vertebrates and from invertebrate phyla. In the twenty-nine metazoan species that have been examined, the complete methylation of lysine-43 is conserved, and it is likely to be conserved throughout the more than two million extant metazoan species. In unicellular eukaryotes and prokaryotes, when the lysine is conserved it is unmethylated, and the stoichiometries of c-subunits vary from 9-15. One possible role for the trimethylated residue is to provide a site for the specific binding of cardiolipin, an essential component of ATP synthases in mitochondria
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