A note on implementing combining networks

In shared-memory multiprocessors, combining networks serve to eliminate hot spots due to concurrent access to the same memory location. Examples are the NYU Ultracomputer, the IBM RP3 and the Fluent Machine. We present a problem that occurs when one tries to implement the Fluent Machine`s network nodes with network chips that do not know their position within the network. We formulate the problem mathematically and present two solutions. The first solution requires some additional hardware around nodes that can be put outside network chips. The second solution requires a minor modification of the routing algorithm, but one can prove that there is no performance loss

HPP : a high performance PRAM

We present a fast shared memory multiprocessor with uniform memory access time. A first prototype (SB-PRAM) is running with 4 processors, a 128 processor version is under construction. A second implementation (HPP) using latest VLSI technology and optical links shall run at a speed of 96 MHz. To achieve this speed, we first investigate the re-design of ASICs and network links. We then balance processor speed and memory bandwidth by investigating the relation between local computation and global memory access in several benchmark applications. On numerical codes such as linpack, 2 and 8 GFlop/s shall be possible with 128 and 512 processors, respectively, thus approaching processor performance of Intel Paragon XPS. As non-numerical codes we consider circuit simulation and raytracing. We achieve speedups over a one processor SGI challenge of 35 and 81 for 128 processors and 140 and 325 for 512 processors

Cytochrome P450 3A-mediated human liver microsomal taxol 6a-hydroxylation

ABSTRACT The antitumor drug taxol was metabolized to one major (6a-hydroxytaxol) and two minor metabolites by human liver microsomes. A 1 0-fold intehndividual variability with a V of 1

The normalized freebase distance

In this paper, we propose the Normalized Freebase Distance (NFD), a new measure for determing semantic concept relatedness that is based on similar principles as the Normalized Web Distance (NWD). We illustrate that the NFD is more effective when comparing ambiguous concepts

What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

BACKGROUND: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. METHODOLOGY: Literature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention or treatment of human diseases?; (2)Are there observed side effects caused by the intake of resveratrol in humans?; (3)What is the relevant dose of resveratrol?; (4)What valid data are available regarding an effect in various species of experimental animals?; (5)Which relevant (overall) mechanisms of action of resveratrol have been documented? CONCLUSIONS/SIGNIFICANCE: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects

To what extent are psychiatrists aware of the comorbid somatic illnesses of their patients with serious mental illnesses? – a cross-sectional secondary data analysis

Background Somatic comorbidities are a serious problem in patients with severe mental illnesses. These comorbidities often remain undiagnosed for a long time. In Germany, physicians are not allowed to access patients’ health insurance data and do not have routine access to documentation from other providers of health care. Against this background, the objective of this article was to investigate psychiatrists’ knowledge of relevant somatic comorbidities in their patients with severe mental illnesses. Methods Cross- sectional secondary data analysis was performed using primary data from a prospective study evaluating a model of integrated care of patients with serious mental illnesses. The primary data were linked with claims data from health insurers. Patients’ diagnoses were derived on the basis of the ICD-10 and the Anatomical Therapeutic Chemical (ATC) classification system. Diabetes, hypertension, coronary artery disease (CAD), hyperlipidaemia, glaucoma, osteoporosis, polyarthritis and chronic obstructive pulmonary disease (COPD) were selected for evaluation. We compared the number of diagnoses reported in the psychiatrists’ clinical report forms with those in the health insurance data. Results The study evaluated records from 1,195 patients with severe mental illnesses. The frequency of documentation of hypertension ranged from 21% in claims data to 4% in psychiatrists’ documentation, for COPD from 12 to 0%, respectively, and for diabetes from 7 to 2%, respectively. The percentage of diagnoses deduced from claims data but not documented by psychiatrists ranged from 68% for diabetes and 83% for hypertension, to 90% for CAD to 98% for COPD. Conclusions The majority of psychiatrists participating in the integrated care programme were insufficiently aware of the somatic comorbidities of their patients. We support allowing physicians to access patients’ entire medical records to increase their knowledge of patients’ medical histories and, consequently, to increase the safety and quality of care

beatLED: the social gaming partyshirt

(Abstract to follow