Where are the Fossils of the First Galaxies? II. True Fossils, Ghost Halos, and the Missing Bright Satellites

We use a new set of cold dark matter simulations of the local universe to investigate the distribution of fossils of primordial dwarf galaxies within, and around the Milky Way. Throughout, we build upon previous results showing agreement between the observed stellar properties of a subset of the ultra-faint dwarfs and our simulated fossils. Here, we show that fossils of the first galaxies have galactocentric distributions and cumulative luminosity functions consistent with observations. In our model there are ~ 300 luminous satellites orbiting the Milky Way, ~50-70% of which are well preserved fossils, with this fraction decreasing with galactocentric distance. Within the Milky Way virial radius, the majority of these fossils have luminosities L_V<10^5 L_solar. This work produces an overabundance of bright dwarf satellites (L_V > 10^4 L_solar) with respect to observations where observations are nearly complete. The "bright satellite problem" is most evident in the outer parts of the Milky Way. We estimate that, although relatively bright, the primordial stellar populations are very diffuse, producing a population with surface brightnesses below surveys` detection limits and are easily stripped by tidal forces. Although we cannot yet present unmistakable evidence for the existence of the fossils of first galaxies in the Local Group, the results of our studies suggest observational strategies that may demonstrate their existence. Primarily, the detection of "ghost halos" of primordial stars around isolated dwarfs would prove that stars formed in minihalos (M<10^8 M_solar) before reionization, and strongly suggest that at least a fraction of the ultra-faint dwarfs are fossils of the first galaxies.Comment: publishing in ApJ with minor revisions in October 2011 V. 741 article ID. 1

PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction

Background/Aims: Renal tissue fibrosis contributes to the development of end-stage renal disease. Causes for renal tissue fibrosis include obstructive nephropathy. The development of renal fibrosis following unilateral ureteral obstruction (UUO) is blunted in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. Similar to Akt isoforms, SGK1 phosphorylates and thus inactivates glycogen synthase kinase GSK-3. The present study explored whether PKB/SGK-dependent phoshorylation of GSK-3α/β impacts on pro-fibrotic signaling following UUO. Methods: UUO was induced in mice carrying a PKB/SGK-resistant GSK-3α/β (gsk-3KI) and corresponding wild-type mice (gsk-3WT). Three days after the obstructive injury, expression of fibrosis markers in kidney tissues was analyzed by quantitative RT-PCR and western blotting. Results: GSK-3α and GSK-3β phosphorylation was absent in both, the non-obstructed and the obstructed kidney tissues from gsk-3KI mice but was increased by UUO in kidney tissues from gsk-3WT mice. Expression of α-smooth muscle actin, type I collagen and type III collagen in the non-obstructed kidney tissues was not significantly different between gsk-3KI mice and gsk-3WT mice but was significantly less increased in the obstructed kidney tissues from gsk-3KI mice than from gsk-3WT mice. After UUO treatment, renal β-catenin protein abundance and renal expression of the β-catenin sensitive genes: c-Myc, Dkk1, Twist and Lef1 were again significantly less increased in kidney tissues from gsk-3KI mice than from gsk-3WT mice. Conclusions: PKB/SGK-dependent phosphorylation of glycogen synthase kinase GSK-3 contributes to the pro-fibrotic signaling leading to renal tissue fibrosis in obstructive nephropathy

Detection of Cell-Fusing Agent virus across ecologically diverse populations of Aedes aegypti on the Caribbean island of Saint Lucia.

Background. Outbreaks of mosquito-borne arboviral diseases including dengue virus (DENV), Zika virus (ZIKV), yellow fever virus (YFV) and chikungunya virus (CHIKV) have recently occurred in the Caribbean. The geographical range of the principal vectors responsible for transmission, Aedes (Ae.) aegypti and Ae. albopictus are increasing and greater mosquito surveillance is needed in the Caribbean given international tourism is so prominent. The island of Saint Lucia has seen outbreaks of DENV and CHIKV in the past five years but vector surveillance has been limited with the last studies dating back to the late 1970s. Natural disasters have changed the landscape of Saint Lucia and the island has gone through significant urbanisation. Methods. In this study, we conducted an entomological survey of Ae. aegypti and Ae. albopictus distribution across the island and analysed environmental parameters associated with the presence of these species in addition to screening for medically important arboviruses and other flaviviruses. Results. Although we collected Ae. aegypti across a range of sites across the island, no Ae. albopictus were collected despite traps being placed in diverse ecological settings. The number of Ae. aegypti collected was significantly associated with higher elevation, and semi-urban settings yielded female mosquito counts per trap-day that were five-fold lower than urban settings. Screening for arboviruses revealed a high prevalence of cell-fusing agent virus (CFAV). Conclusions. Outbreaks of arboviruses transmitted by Ae. aegypti and Ae. albopictus have a history of occurring in small tropical islands and Saint Lucia is particularly vulnerable given the limited resources available to undertake vector control and manage outbreaks. Surveillance strategies can identify risk areas for predicting future outbreaks. Further research is needed to determine the diversity of current mosquito species, investigate insect-specific viruses, as well as pathogenic arboviruses, and this should also be extended to the neighbouring smaller Caribbean islands

An Evaluation of the National Empowerment Project Cultural, Social, and Emotional Wellbeing Program

 An array of cumulative risk and stress factors, and social inequities, have contributed to high suicides and family and community dysfunction, in two communities in Queensland. An independent, post-program evaluation of the National Empowerment Project (NEP) Cultural, Social and Emotional Wellbeing (CSEWB) Program specifically developed to address these issues was conducted in Kuranda and Cherbourg communities, Queensland in early 2017. Summaries of 153 stories of most significant change (SMSC) and 30 interviews undertaken with participants who completed the CSEWB program informed the evaluation. The evaluation assessed if, and how, the CSEWB program contributed to strengthening the cultural, social, and emotional wellbeing of participants, their families and communities. Participant’s interviews describe how the CSEWB Program significantly changed their lives and their families’ lives in various constructive and affirming ways to bring about positive outcomes. The extent of significant changes reported are compelling, and they highlight the need for greater government commitment to services and programs which address the social determinants influencing social and emotional wellbeing (SEWB) within Indigenous communities around Australia

Enhancing spaceflight safety with UOS3 cubesat

Earth orbits are becoming increasingly congested. This will not only impact future space operations but also become a concern for the population on the ground; with more spacecraft being flown, more objects will re-enter the atmosphere in an uncontrolled fashion. Parts of these satellites can reach Earth surface and endanger the ground population (e.g. ROSAT or UARS satellites). A student-run project from the University of Southampton aims to build a 1U cubesat (approx. 10 by 10 by 10 cm satellite), which will gather data that will improve the accuracy of re-entry predictions. The cubesat will record and deliver its position and attitude during the orbital decay, thus providing validation data for re-entry prediction tools. This will reduce the risk to the ground population because more accurate prognoses will allow mitigation measures to be implemented in the areas at risk. The mission could also allow the risk of collision between spacecraft to be estimated more accurately thanks to improvement of the atmospheric models. This would give the decision makers more complete information to use, for instance, in collision avoidance manoeuvre plannin

Calibration database for the Murchison Widefield Array All-Sky Virtual Observatory

We present a calibration component for the Murchison Widefield Array All-Sky Virtual Observatory (MWA ASVO) utilising a newly developed PostgreSQL database of calibration solutions. Since its inauguration in 2013, the MWA has recorded over thirty-four petabytes of data archived at the Pawsey Supercomputing Centre. According to the MWA Data Access policy, data become publicly available eighteen months after collection. Therefore, most of the archival data are now available to the public. Access to public data was provided in 2017 via the MWA ASVO interface, which allowed researchers worldwide to download MWA uncalibrated data in standard radio astronomy data formats (CASA measurement sets or UV FITS files). The addition of the MWA ASVO calibration feature opens a new, powerful avenue for researchers without a detailed knowledge of the MWA telescope and data processing to download calibrated visibility data and create images using standard radio-astronomy software packages. In order to populate the database with calibration solutions from the last six years we developed fully automated pipelines. A near-real-time pipeline has been used to process new calibration observations as soon as they are collected and upload calibration solutions to the database, which enables monitoring of the interferometric performance of the telescope. Based on this database we present an analysis of the stability of the MWA calibration solutions over long time intervals.Comment: 12 pages, 9 figures, Accepted for publication in PAS

Where are the Fossils of the First Galaxies? I. Local Volume Maps and Properties of the Undetected Dwarfs

We present a new method for generating initial conditions for LCDM N-body simulations which provides the dynamical range necessary to follow the evolution and distribution of the fossils of the first galaxies on Local Volume, 5-10 Mpc, scales. The initial distribution of particles represents the position, velocity and mass distribution of the dark and luminous halos extracted from pre-reionization simulations. We confirm previous results that ultra-faint dwarfs have properties compatible with being well preserved fossils of the first galaxies. However, because the brightest pre-reionization dwarfs form preferentially in biased regions, they most likely merge into non-fossil halos with circular velocities >20-30 km/s. Hence, we find that the maximum luminosity of true-fossils in the Milky Way is L_V<10^5 L_solar, casting doubts on the interpretation that some classical dSphs are true-fossils. In addition, we argue that most ultra-faints at small galactocentric distance, R<50 kpc, had their stellar properties modified by tides, while a large population of fossils is still undetected due to their extremely low surface brightness log(Sigma_V) < -1.4. We estimate that the region outside R_50 (~ 400 kpc) up to 1 Mpc from the Milky Way contains about a hundred true fossils of the first galaxies with V-band luminosities 10^3 - 10^5 L_solar and half-light radii, r_hl ~ 100-1000 pc.Comment: published in ApJ October 2011 with minor revisions V. 741 article ID. 1

Improved Techniques for the Surveillance of the Near Earth Space Environment with the Murchison Widefield Array

In this paper we demonstrate improved techniques to extend coherent processing intervals for passive radar processing, with the Murchison Widefield Array. Specifically, we apply a two stage linear range and Doppler migration compensation by utilising Keystone Formatting and a recent dechirping method. These methods are used to further demonstrate the potential for the surveillance of space with the Murchison Widefield Array using passive radar, by detecting objects orders of magnitude smaller than previous work. This paper also demonstrates how the linear Doppler migration methods can be extended to higher order compensation to further increase potential processing intervals.Comment: Presented at the 2019 IEEE Radar Conference in Boston earlier this yea

Independent discovery of a nulling pulsar with unusual subpulse drifting properties with the Murchison Widefield Array

We report the independent discovery of PSR J0026-1955 with the Murchison Widefield Array (MWA) in the ongoing Southern-sky MWA Rapid Two-metre pulsar survey. J0026-1955 has a period of ∼1.306 s, a dispersion measure of ∼20.869 pc cm-3, and a nulling fraction of ∼77%. This pulsar highlights the advantages of the survey's long dwell times (∼80 minutes), which, when fully searched, will be sensitive to the expected population of similarly bright, intermittent pulsars with long nulls. A single-pulse analysis in the MWA's 140-170 MHz band also reveals a complex subpulse drifting behavior, including both rapid changes of the drift rate characteristic of mode switching pulsars, as well as a slow, consistent evolution of the drift rate within modes. In some longer drift sequences, interruptions in the otherwise smooth drift rate evolution occur preferentially at a particular phase, typically lasting a few pulses. These properties make this pulsar an ideal test bed for prevailing models of drifting behavior such as the carousel model