9,378 research outputs found
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study.
BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of high-risk human papillomavirus (H-HPV) infection. Carbonic anhydrase-IX (CA-IX) is highly expressed in conventional glandular lesions (CGLs). However, expression of CA-IX in LEGH or GA has not been studied.MethodsIn all, 12 CGLs, 7 LEGHs, 6 LEGHs with coexisting adenocarcinoma in situ (AIS, 3) and GA (3) were identified from Japanese women with a cytological diagnosis of atypical glandular cells of undetermined significance. Immunostaining was used to detect CA-IX and p16(INK)4(a) (hereafter termed p16) protein expression in the tissues and CA-IX protein expression in the Papanicolaou smears (PSs). Polymerase chain reaction was used to detect H-HPV DNA in liquid-based cytology.ResultsOut of 12 (83%) CGLs, 10 were positive with H-HPV and high levels of CA-IX expression were seen in all (100%) cases. P16 protein expression was observed in 11 out of 12 (92%) cases. None of the LEGHs, LEGHs with AIS or GA were positive for H-HPV and only 8 out of 13 (62%) showed focal weak (1+) p16 expression. In contrast, all cases (100%) exhibited strong CA-IX protein expression.ConclusionOur study suggests that there are different molecular mechanisms of carcinogenesis resulting in CGLs vs LEGHs associated with AIS or GA. There is also a possible link between LEGHs and GAs. Furthermore, CA-IX expression may serve as a useful biomarker for the detection of GAs in the absence of H-HPV infection
Bats Use Magnetite to Detect the Earth's Magnetic Field
While the role of magnetic cues for compass orientation has been confirmed in numerous animals, the mechanism of detection is still debated. Two hypotheses have been proposed, one based on a light dependent mechanism, apparently used by birds and another based on a “compass organelle” containing the iron oxide particles magnetite (Fe3O4). Bats have recently been shown to use magnetic cues for compass orientation but the method by which they detect the Earth's magnetic field remains unknown. Here we use the classic “Kalmijn-Blakemore” pulse re-magnetization experiment, whereby the polarity of cellular magnetite is reversed. The results demonstrate that the big brown bat Eptesicus fuscus uses single domain magnetite to detect the Earths magnetic field and the response indicates a polarity based receptor. Polarity detection is a prerequisite for the use of magnetite as a compass and suggests that big brown bats use magnetite to detect the magnetic field as a compass. Our results indicate the possibility that sensory cells in bats contain freely rotating magnetite particles, which appears not to be the case in birds. It is crucial that the ultrastructure of the magnetite containing magnetoreceptors is described for our understanding of magnetoreception in animals
Trends in the burden of varicella in UK general practice.
Childhood varicella vaccination has not yet been introduced in the UK. To inform decision-making about future vaccine programmes, data on the burden of varicella in general practice over a 10-year period (01/01/2005-31/12/2014) was calculated by age and ethnicity, using anonymised data from >8 million individuals in the Clinical Practice Research Datalink. Varicella consultations peaked at 20 603 in 2007, then decreased annually in all age groups to 11 243 in 2014. Each year, consultation rates were common among infants, were highest among 1-3 year olds (61·2 consultations/1000 person-years in 2007, 39·7/1000 person-years in 2014) and then fell with increasing age to <1·0/1000 person-years at ages ⩾20 years. Varicella acquisition appeared to be delayed in some ethnic groups, with lower consultation rates for children aged <3 years but increased rates for older children and adults aged ⩽40 years among those of black African, Afro-Caribbean, South Asian or other Asian ethnicity. Decreasing general practice consultation rates over time could reflect changes in healthcare utilisation, with patients seeking care in alternative settings such as Accident and Emergency Departments, although current data prevent full assessment of this. Availability of data on varicella diagnoses across all health settings would enable estimation of the total healthcare burden due to varicella and the cost-effectiveness of introducing varicella vaccination
Where do we go from here? An assessment of navigation performance using a compass versus a GPS unit
The Global Positioning System (GPS) looks set to replace the traditional map and
compass for navigation tasks in military and civil domains. However, we may ask
whether GPS has a real performance advantage over traditional methods. We present
an exploratory study using a waypoint plotting task to compare the standard magnetic
compass against a military GPS unit, for both expert and non-expert navigators.
Whilst performance times were generally longer in setting up the GPS unit, once
navigation was underway the GPS was more efficient than the compass. For mediumto
long-term missions, this means that GPS could offer significant performance
benefits, although the compass remains superior for shorter missions.
Notwithstanding the performance times, significantly more errors, and more serious
errors, occurred when using the compass. Overall, then, the GPS offers some clear
advantages, especially for non-expert users. Nonetheless, concerns over the
development of cognitive maps remain when using GPS technologies
Approximation of the critical buckling factor for composite panels
This article is concerned with the approximation of the critical buckling factor for thin composite plates. A new method to improve the approximation of this critical factor is applied based on its behavior with respect to lamination parameters and loading conditions. This method allows accurate approximation of the critical buckling factor for non-orthotropic laminates under complex combined loadings (including shear loading). The influence of the stacking sequence and loading conditions is extensively studied as well as properties of the critical buckling factor behavior (e.g concavity over tensor D or out-of-plane lamination parameters). Moreover, the critical buckling factor is numerically shown to be piecewise linear for orthotropic laminates under combined loading whenever shear remains low and it is also shown to be piecewise continuous in the general case. Based on the numerically observed behavior, a new scheme for the approximation is applied that separates each buckling mode and builds linear, polynomial or rational regressions for each mode. Results of this approach and applications to structural optimization are presented
A Tale of Two Animats: What does it take to have goals?
What does it take for a system, biological or not, to have goals? Here, this
question is approached in the context of in silico artificial evolution. By
examining the informational and causal properties of artificial organisms
('animats') controlled by small, adaptive neural networks (Markov Brains), this
essay discusses necessary requirements for intrinsic information, autonomy, and
meaning. The focus lies on comparing two types of Markov Brains that evolved in
the same simple environment: one with purely feedforward connections between
its elements, the other with an integrated set of elements that causally
constrain each other. While both types of brains 'process' information about
their environment and are equally fit, only the integrated one forms a causally
autonomous entity above a background of external influences. This suggests that
to assess whether goals are meaningful for a system itself, it is important to
understand what the system is, rather than what it does.Comment: This article is a contribution to the FQXi 2016-2017 essay contest
"Wandering Towards a Goal
Seismotectonics and rupture process of the MW 7.1 2011 Van reverse-faulting earthquake, eastern Turkey, and implications for hazard in regions of distributed shortening
The 2011 October 23 MW 7.1 Van earthquake in eastern Turkey caused ~600 deaths and caused widespread damage and economic loss. The seismogenic rupture was restricted to 10-25 km in depth, but aseismic surface creep, coincident with outcrop fault exposures, was observed in the hours to months after the earthquake. We combine observations from radar interferometry, seismology, geomorphology and Quaternary dating to investigate the geological slip rate and seismotectonic context of the Van earthquake, and assess the implications for continuing seismic hazard in the region. Transient post-seismic slip on the upper Van fault started immediately following the earthquake, and decayed over a period of weeks; it may not fully account for our long-term surface slip-rate estimate of ≥ 0.5 mm yr-1. Post-seismic slip on the Bostaniçi splay fault initiated several days to weeks after the main shock, and we infer that it may have followed the MW 5.9 aftershock on the 9th November. The Van earthquake shows that updip segmentation can be important in arresting seismic ruptures on dip-slip faults. Two large, shallow aftershocks show that the upper 10 km of crust can sustain significant earthquakes, and significant slip is observed to have reached the surface in the late Quaternary, so there may be a continuing seismic hazard from the upper Van fault and the associated splay. The wavelength of folding in the hanging wall of the Van fault is dominated by the structure in the upper 10 km of the crust, masking the effect of deeper seismogenic structures. Thus, models of subsurface faulting based solely on surface folding and faulting in regions of reverse faulting may underestimate the full depth extent of seismogenic structures in the region. In measuring the cumulative post-seismic offsets to anthropogenic structures, we show that Structure-from-Motion can be rapidly deployed to create snapshots of postseismic displacement.We also demonstrate the utility of declassified Corona mission imagery (1960s-1970s) for geomorphic mapping in areas where recent urbanization has concealed the geomorphic markers
Experimental evaluation of interference alignment for broadband WLAN systems
In this paper, we present an experimental study on the performance of spatial interference alignment (IA) in indoor wireless local area network scenarios that use orthogonal frequency division multiplexing (OFDM) according to the physical-layer specifications of the IEEE 802.11a standard. Experiments have been carried out using a wireless network testbed capable of implementing a 3-user MIMO interference channel. We have implemented IA decoding schemes that can be designed according to distinct criteria (e.g., zero-forcing or MaxSINR). The measurement methodology has been validated considering practical issues like the number of OFDM training symbols used for channel estimation or feedback time. In case of asynchronous users, a time-domain IA decoding filter is also compared to its frequency domain counterpart. We also evaluated the performance of IA from bit error ratio measurement-based results in comparison to different time-division multiple access transmission schemes. The comparison includes single- and multiple-antenna systems transmitting over the dominant mode of the MIMO channel. Our results indicate that spatial IA is suitable for practical indoor scenarios in which wireless channels often exhibit relatively large coherence times.This work has been supported by Xunta de Galicia, MINECO of Spain, and by
FEDER funds of the E.U. under Grant 2012/287, Grant TEC2013-47141-C4-R
(RACHEL project), Grant CSD2008-00010 (COMONSENS project), and FPU
Grants AP2010-2189 and AP2009-1105
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