Prospectus, November 19, 1971

BROADCASTING COMES TO PARKLAND; National Award to Parkland Instructor; Registration Requirements; Final Examination Schedule; Registration Schedule; Study Area or Playground; Parkland\u27s Pig Sty; Voting and Registration Requirements; Susie Speaks; Letter to Editor; A Dream come true ; Play Misty For Me ; SWAMP is here to stay; Mother Goosey: Humpty Dumpty; What\u27s going on: Free Decals, Thanksgiving LRC Hours, Free bowling and pool, Student Employment, Phi Beta Lambda, Student Parking, TAU Epsilon, I.O.C., Student Services, Bake Sale, Turkey Raffle; Counseling.....A Full Service; Meet Your Counselors; Hart Beat; Wrestlers - Strongest Ever; Basketball Schedule; Wrestling Schedulehttps://spark.parkland.edu/prospectus_1971/1001/thumbnail.jp

The Ursinus Weekly, November 8, 1973

Dr. Pancoast predicts much competition for teachers • Civil service commission announces test dates • Service organization shows true colors • Christmas concert • Campus Chest schedules fund raising activities • Concert cancellation • Editorial: When the life sciences become the death sciences • Letters to the editor: Beef over rhetoric; Physics dept. maintains status quo; A plea for silence; What are we doing here? • Alumni corner • Faculty Portrait: Mr. Ted Xaras • The stage: ProTheatre begins year with three one-act plays in new theatre • A bundle of letters • Film: “Jeremy” • Third team goes undefeated! • Football Bears tie, 21-21 • Once beaten Harriers enter MAC championship • Women’s volleyball team into actionhttps://digitalcommons.ursinus.edu/weekly/1005/thumbnail.jp

Presence: Twelve Artists

Show card featuring alumni and faculty.https://digitalcommons.udallas.edu/alumni_87-88/1009/thumbnail.jp

Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay

Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolated from the sponge Xestospongia cf. carbonaria, collected in Palau. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1–6 were evaluated in a zebrafish phenotype-based assay. Amphimedine (4) was the only compound that caused a phenotype in zebrafish embryos at 30 μM. No phenotype other than death was observed for compounds 1–3, 5, 6

Impact of a Randomized Campus/Community Trial to Prevent High-Risk Drinking Among College Students

High-risk drinking by college students continues to pose a significant threat to public health. Despite increasing evidence of the contribution of community-level and campus-level environmental factors to high risk drinking, there have been few rigorous tests of interventions that focus on changing these interlinked environments. The Study to Prevent Alcohol Related Consequences (SPARC) assessed the efficacy of a comprehensive intervention using a community organizing approach to implement environmental strategies in and around college campuses. The goal of SPARC was to reduce high-risk drinking and alcohol-related consequences among college students

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

AbstractObjectiveWe sought to assess whether genetic risk factors for atrial fibrillation can explain cardioembolic stroke risk.MethodsWe evaluated genetic correlations between a prior genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously-validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.ResultsWe observed strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson’s r=0.77 and 0.76, respectively, across SNPs with p &lt; 4.4 × 10−4 in the prior AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio (OR) per standard deviation (sd) = 1.40, p = 1.45×10−48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per sd = 1.07, p = 0.004), but no other primary stroke subtypes (all p &gt; 0.1).ConclusionsGenetic risk for AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.</jats:sec

Office Automation Technology and Concepts

X, 337 tr.; 23 cm

Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs

Correction: Volume65, Issue6 Article Numbere00653- 21 DOI10.1128/AAC.00653-21Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry. We hypothesize that repurposing of combinations of orally administered approved drugs provides effective suppression of arenaviruses. In this report, we demonstrate that arbidol, an approved influenza antiviral previously shown to inhibit EBOV, LASV, and many other viruses, inhibits murine leukemia virus (MLV) reporter viruses pseudotyped with the fusion glycoproteins (GPs) of other arenaviruses (Junin virus (JUNV], lymphocytic choriomeningitis virus (LCMV), and Pichinde virus (PICA). Arbidol and other approved drugs, including aripiprazole, amodiaquine, sertraline, and niclosamide, also inhibit infection of cells by infectious PICV, and arbidol, sertraline, and niclosamide inhibit infectious LASV. Combining arbidol with aripiprazole or sertraline results in the synergistic suppression of LASV and JUNV GP-bearing pseudoviruses. This proof-of-concept study shows that arenavirus infection in vitro can be synergistically inhibited by combinations of approved drugs. This approach may lead to a proactive strategy with which to prepare for and control known and new arenavirus outbreaks.Peer reviewe

Thiazoline Peptides and a Tris-Phenethyl Urea from <i>Didemnum molle</i> with Anti-HIV Activity

As part of our screening for anti-HIV agents from marine invertebrates, the MeOH extract of <i>Didemnum molle</i> was tested and showed moderate <i>in vitro</i> anti-HIV activity. Bioassay-guided fractionation of a large-scale extract allowed the identification of two new cyclopeptides, mollamides E and F (<b>1</b> and <b>2</b>), and one new tris-phenethyl urea, molleurea A (<b>3</b>). The absolute configurations were established using the advanced Marfey’s method. The three compounds were evaluated for anti-HIV activity in both an HIV integrase inhibition assay and a cytoprotective cell-based assay. Compound <b>2</b> was active in both assays with IC₅₀ values of 39 and 78 μM, respectively. Compound <b>3</b> was active only in the cytoprotective cell-based assay, with an IC₅₀ value of 60 μM