A Mikola-hagyaték gondozása = Taking care of Mikola-heritage

"A Mikola-hagyaték gondozása" c. kutatási program három területre irányult. (1) Mikola Tibor 1997-ben védte meg akadémiai doktori értekezését, melyben a szamojéd nyelvek történetét tárgyalta. E munkája nem jelent meg nyomtatásban. A kéziratot németre fordíttattuk, majd alapos szerkesztési munkálatokat követően megjelentettük. Tibor Mikola: Studien zur Geschichte der samojedischen Sprachen, aus dem Nachlass herausgegeben von Beáta Wagner-Nagy = Studia-Uralo-Altaica 45, SZTE Finnisch-Ugrisches Institut, Szeged, 175.pp.; ISBN 963 482 679 2 (2) A négyéves program során Wagner-Nagy Beáta elkészítette a nganaszan nyelv morfológiai elemző szótárát. A szótár elektronikus formában készült el, a DB-creator program segítségével használható, alkalmas fonetikai, morfológiai és szintaktikai kutatások végzésére. Mivel jelenleg ez a legteljesebb nganaszan szótár, így lexikai vizsgálatokra is felhasználható. Elektromos formában CD-n terjeszthető, és szerzője tervezi nyomtatott formában való megjelentetését is. (3) Mikola Tibor több évtizedes oktatói munkája során mindig tartott általános uralisztikai tárgyú kurzusokat. E kurzusok tematikáját, valamint Mikola Tibornak a témákhoz kapcsolódó publikációit felhasználva Uralisztika c. oktatási segédanyagot készítettünk, mely mind a magyar szakosok, mind a finnugor szakos hallgatók képzésében hasznosítható. A könyv megjelenése 2006 nyarán várható. | The project targeted three fields. 1. Prof. Tibor Mikola defended his academic dissertation in 1997. Before the start of the project, the work was unpublished. We had the manuscript translated into German, and after a careful edition it was published. (Tibor Mikola: Studien zur Geschichte der samojedischen Sprachen, aus dem Nachlass herausgegeben von Beáta Wagner-Nagy = Studia-Uralo-Altaica 45, SZTE Finnisch-Ugrisches Institut, Szeged, 175. Pp.; ISBN 963 482 679 2) 2. Beáta Wagner-Nagy compiled a Nganasan morphological dictionary during the 4-year program. The dictionary is available in electronic form, its use is supported by DB-creator software and suitable for fonetical, morphological and syntatical research. As this is the most up-to-date Nganasan dictionary, it can be used for lexical investigations. It is available on CD in digital form and the author is planning to publish it, too. 3. Tibor Mikola gave lectures on Uralistics incessantly during his whole carrier. The staff of the Finno-Ugric Dept. of SZTE compiled a course book for students studying Hungarian or Finno-Ugric linguistics using the thematics of Mikola's courses as well as his publications related to these topics

Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis

Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL; p < 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg; p < 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94, p = 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82, p = 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209; p = 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71, p = 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients

Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes

Interleukin-6 (IL-6) has emerged as a potent biomarker for depression as its elevated plasma levels in patients with clinical depression have been confirmed by meta-analyses. Increased plasma IL-6 concentration was associated with various psychological stress factors and physical disorders accompanied by pain. Another modulator of the IL-6 level is rs1800795, a promoter polymorphism in the IL-6 gene which is able to influence its expression rate. Therefore, we examined in a Hungarian population sample of 1053 volunteers with European origins if rs1800795 polymorphism can affect depression symptoms measured by Zung Self-rating Depression Scale (ZSDS), and Brief Symptom Inventory (BSI). We also investigated the interactions of the polymorphism with reported painful physical conditions and Recent Negative Life Events (RLE) measured by the List of Life Threatening Experiences. Rs1800795 significantly interacted with both RLE and painful condition on depressive symptoms measured by ZSDS and BSI using different heritability models, while no main effects of the polymorphism were identified. After correction for multiple testing only the rs1800795 x RLE interaction effect (recessive model) remained significant on the BSI score, while both RLE and painful conditions significantly interacted on the ZSDS. In conclusion, the functional IL-6 rs1800795 polymorphism in interaction with various stress factors increases the risk of depression and has a greater impact on symptoms measured by the ZSDS. Thus, IL-6 and other cytokines may be more relevant in the development of somatic symptoms compared to affective signs of depression, delineating a specific genotype-phenotype relationship in this heterogeneous disorder

Aldosterone Antagonists in Monotherapy Are Protective against Streptozotocin-Induced Diabetic Nephropathy in Rats

Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) are the standard clinical therapy of diabetic nephropathy (DN), while aldosterone antagonists are only used as adjuncts. Previously in experimental DN we showed that Na/K ATPase (NKA) is mislocated and angiotensin II leads to superimposed renal progression. Here we investigated the monotherapeutic effect of aldosterone blockers on the progression of DN and renal NKA alteration in comparison to ACEi and ARBs. Streptozotocin-diabetic rats developing DN were treated with aldosterone antagonists; ACEi and ARB. Renal function, morphology, protein level and tubular localization of NKA were analyzed. To evaluate the effect of high glucose per se; HK-2 proximal tubular cells were cultured in normal or high concentration of glucose and treated with the same agents. Aldosterone antagonists were the most effective in ameliorating functional and structural kidney damage and they normalized diabetes induced bradycardia and weight loss. Aldosterone blockers also prevented hyperglycemia and diabetes induced increase in NKA protein level and enzyme mislocation. A monotherapy with aldosterone antagonists might be as, or more effective than ACEi or ARBs in the prevention of STZ-induced DN. Furthermore the alteration of the NKA could represent a novel pathophysiological feature of DN and might serve as an additional target of aldosterone blockers

Metabolic and renal parameters of control, diabetic and treated diabetic rats.

<p>Data are means ± SD, n = 8–10/group, ^*p<0.05 vs. C; ^§p<0.05 vs. D, ^**p<0.01 vs. C; ^§§p<0.01 vs. D, ^***p<0.001 vs. C; ^§§§p<0.001 vs. D; respectively. UD–undetectable.</p