2,252 research outputs found

    PCV105 THE INITIATION AND EXTENT OF DOSE TITRATION OF ACE INHIBITORS AND β-BLOCKERS POST ACUTE MYOCARDIAL INFARCTION: A PROSPECTIVE AUDIT

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    Gene expression of endangered coral (Orbicella spp.) in flower garden banks National Marine Sanctuary after Hurricane Harvey

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    About 190 km south of the Texas–Louisiana border, the East and West Flower Garden Banks (FGB) have maintained > 50% coral cover with infrequent and minor incidents of disease or bleaching since monitoring began in the 1970s. However, a mortality event, affecting 5.6 ha (2.6% of the area) of the East FGB, occurred in late July 2016 and coincided with storm-generated freshwater runoff extending offshore and over the reef system. To capture the immediate effects of storm-driven freshwater runoff on coral and symbiont physiology, we leveraged the heavy rainfall associated with Hurricane Harvey in late August 2017 by sampling FGB corals at two time points: September 2017, when surface water salinity was reduced (∼34 ppt); and 1 month later when salinity had returned to typical levels (∼36 ppt in October 2017). Tissue samples (N = 47) collected midday were immediately preserved for gene expression profiling from two congeneric coral species (Orbicella faveolata and Orbicella franksi) from the East and West FGB to determine the physiological consequences of storm-derived runoff. In the coral, differences between host species and sampling time points accounted for the majority of differentially expressed genes. Gene ontology enrichment for genes differentially expressed immediately after Hurricane Harvey indicated increases in cellular oxidative stress responses. Although tissue loss was not observed on FGB reefs following Hurricane Harvey, our results suggest that poor water quality following this storm caused FGB corals to experience sub-lethal stress. We also found dramatic expression differences across sampling time points in the coral’s algal symbiont, Breviolum minutum. Some of these differentially expressed genes may be involved in the symbionts’ response to changing environments, including a group of differentially expressed post-transcriptional RNA modification genes. In this study, we cannot disentangle the effects of reduced salinity from the collection time point, so these expression patterns could also be related to seasonality. These findings highlight the urgent need for continued monitoring of these reef systems to establish a baseline for gene expression of healthy corals in the FGB system across seasons, as well as the need for integrated solutions to manage stormwater runoff in the Gulf of Mexico.https://www.frontiersin.org/articles/10.3389/fmars.2019.00672/fullPublished versionPublished versio

    A Semantic Data Grid for Satellite Mission Quality Analysis

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    The combination of Semantic Web and Grid technologies and architectures cases the development of applications that share heterogeneous resource,, (data and computing elements) that belong to several organisations. The Aerospace domain has an extensive and heterogeneous network of facilities and institutions, with a strong need to share both data and computational resources for complex processing tasks. One such task is monitoring and data analysis for Satellite Missions. This paper presents a Semantic Data Grid for satellite missions, where flexibility, scalability, interoperability, extensibility and efficient development have been considered the key issues to be addressed

    Symbiont Community Diversity is More Variable in Corals That Respond Poorly to Stress

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    Coral reefs are declining globally as climate change and local water quality press environmental conditions beyond the physiological tolerances of holobionts—the collective of the host and its microbial symbionts. To assess the relationship between symbiont composition and holobiont stress tolerance, community diversity metrics were quantified for dinoflagellate endosymbionts (Family: Symbiodiniaceae) from eight Acropora millepora genets that thrived under or responded poorly to various stressors. These eight selected genets represent the upper and lower tails of the response distribution of 40 coral genets that were exposed to four stress treatments (and control conditions) in a 10-day experiment. Specifically, four ‘best performer’ coral genets were analyzed at the end of the experiment because they survived high temperature, high pCO2, bacterial exposure, or combined stressors, whereas four ‘worst performer’ genets were characterized because they experienced substantial mortality under these stressors. At the end of the experiment, seven of eight coral genets mainly hosted Cladocopium symbionts, whereas the eighth genet was dominated by both Cladocopium and Durusdinium symbionts. Symbiodiniaceae alpha and beta diversity were higher in worst performing genets than in best performing genets. Symbiont communities in worst performers also differed more after stress exposure relative to their controls (based on normalized proportional differences in beta diversity), than did best performers. A generalized joint attribute model estimated the influence of host genet and treatment on Symbiodiniaceae community composition and identified strong associations among particular symbionts and host genet performance, as well as weaker associations with treatment. Although dominant symbiont physiology and function contribute to host performance, these findings emphasize the importance of symbiont community diversity and stochasticity as components of host performance. Our findings also suggest that symbiont community diversity metrics may function as indicators of resilience and have potential applications in diverse disciplines from climate change adaptation to agriculture and medicine

    The Minimally Tuned Minimal Supersymmetric Standard Model

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    The regions in the Minimal Supersymmetric Standard Model with the minimal amount of fine-tuning of electroweak symmetry breaking are presented for general messenger scale. No a priori relations among the soft supersymmetry breaking parameters are assumed and fine-tuning is minimized with respect to all the important parameters which affect electroweak symmetry breaking. The superpartner spectra in the minimally tuned region of parameter space are quite distinctive with large stop mixing at the low scale and negative squark soft masses at the high scale. The minimal amount of tuning increases enormously for a Higgs mass beyond roughly 120 GeV.Comment: 38 pages, including 2 appendices, 8 figure

    Lyapunov exponents for products of complex Gaussian random matrices

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    The exact value of the Lyapunov exponents for the random matrix product PN=ANAN−1...A1P_N = A_N A_{N-1}...A_1 with each Ai=Σ1/2GicA_i = \Sigma^{1/2} G_i^{\rm c}, where Σ\Sigma is a fixed d×dd \times d positive definite matrix and GicG_i^{\rm c} a d×dd \times d complex Gaussian matrix with entries standard complex normals, are calculated. Also obtained is an exact expression for the sum of the Lyapunov exponents in both the complex and real cases, and the Lyapunov exponents for diffusing complex matrices.Comment: 15 page

    Galaxy And Mass Assembly (GAMA): the signatures of galaxy interactions as viewed from small scale galaxy clustering

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    Statistical studies of galaxy–galaxy interactions often utilize net change in physical properties of progenitors as a function of the separation between their nuclei to trace both the strength and the observable time-scale of their interaction. In this study, we use two-point auto-, cross-, and mark-correlation functions to investigate the extent to which small-scale clustering properties of star-forming galaxies can be used to gain physical insight into galaxy–galaxy interactions between galaxies of similar optical brightness and stellar mass. The H α star formers, drawn from the highly spatially complete Galaxy And Mass Assembly (GAMA) survey, show an increase in clustering at small separations. Moreover, the clustering strength shows a strong dependence on optical brightness and stellar mass, where (1) the clustering amplitude of optically brighter galaxies at a given separation is larger than that of optically fainter systems, (2) the small-scale-clustering properties (e.g. the strength, the scale at which the signal relative to the fiducial power law plateaus) of star-forming galaxies appear to differ as a function of increasing optical brightness of galaxies. According to cross- and mark-correlation analyses, the former result is largely driven by the increased dust content in optically bright star-forming galaxies. The latter could be interpreted as evidence of a correlation between interaction-scale and optical brightness of galaxies, where physical evidence of interactions between optically bright star formers, likely hosted within relatively massive haloes, persists over larger separations than those between optically faint star formers

    Remineralization effect of CPP-ACP and fluoride for white spot lesions in vitro

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    This in vitro study compared the remineralization effect on white spot lesions of casein phosphopeptide-amorphous calcium phosphate crème, or CPP-ACP (MI Paste™), 1.1% NaF dentifrice containing 5000 ppm of fluoride (ControlRX™), or CPP-ACP crème with 900 ppm of fluoride (MI Paste Plus™) with that of a control
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