11 research outputs found

    The Application of Electric Current Computed Tomography to Defect Imaging in Metals

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    Electric Current Computed Tomography (ECCT) is a technique for producing images of the electrical resistivity profile within a body from measurements made on the body’s exterior. To make these measurements, an array of electrodes is attached to the surface of the body. Sets of current patterns are applied through these electrodes and the voltages needed to maintain these specified currents are measured and recorded. These applied currents and measured voltages are then used in a reconstruction algorithm to produce images that represent approximations to the electrical resistivity distribution in the interior of the body.</p

    Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

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    Contains fulltext : 97744.pdf (publisher's version ) (Open Access)BACKGROUND: M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. RESULTS: The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH), which posits that the species genome possesses a far greater number of genes than any single isolate. Multiple and pair-wise whole genome alignments highlight limited chromosomal re-arrangement. CONCLUSIONS: M. catarrhalis gene content and chromosomal organization data, although supportive of the DGH, show modest overall genic diversity. These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens

    Leukämien

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    Organolead Compounds

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