High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment

To evaluate ankle joint abnormalities in a knee osteoarthritis (OA) cohort

Liquid State Anomalies for the Stell-Hemmer Core-Softened Potential

We study the Stell-Hemmer potential using both analytic (exact $1d$ and approximate $2d$) solutions and numerical $2d$ simulations. We observe in the liquid phase an anomalous decrease in specific volume and isothermal compressibility upon heating, and an anomalous increase in the diffusion coefficient with pressure. We relate the anomalies to the existence of two different local structures in the liquid phase. Our results are consistent with the possibility of a low temperature/high pressure liquid-liquid phase transition.Comment: 4 pages in one gzipped ps file including 11 figures; One RevTex and 11 gzipped eps figure

Controversies in epilepsy: Debates held during the Fourth International Workshop on Seizure Prediction

Debates on six controversial topics were held during the Fourth International Workshop on Seizure Prediction (IWSP4) convened in Kansas City, KS, USA, July 4–7, 2009. The topics were (1) Ictogenesis: Focus versus Network? (2) Spikes and Seizures: Step-relatives or Siblings? (3) Ictogenesis: A Result of Hyposynchrony? (4) Can Focal Seizures Be Caused by Excessive Inhibition? (5) Do High-Frequency Oscillations Provide Relevant Independent Information? (6) Phase Synchronization: Is It Worthwhile as Measured? This article, written by the IWSP4 organizing committee and the debaters, summarizes the arguments presented during the debates

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Demand-side approaches for limiting global warming to 1.5 °C

The Paris Climate Agreement defined an ambition of limiting global warming to 1.5 °C above preindustrial levels. This has triggered research on stringent emission reduction targets and corresponding mitigation pathways across energy economy and societal systems. Driven by methodological considerations, supply side and carbon dioxide removal options feature prominently in the emerging pathway literature, while much less attention has been given to the role of demand-side approaches. This special issue addresses this gap, and aims to broaden and strengthen the knowledge base in this key research and policy area. This editorial paper synthesizes the special issue’s contributions horizontally through three shared themes we identify: policy interventions, demand-side measures, and methodological approaches. The review of articles is supplemented by insights from other relevant literature. Overall, our paper underlines that stringent demand-side policy portfolios are required to drive the pace and direction of deep decarbonization pathways and keep the 1.5 °C target within reach. It confirms that insufficient attention has been paid to demand-side measures, which are found to be inextricably linked to supply-side decarbonization and able to complement supply-side measures. The paper also shows that there is an abundance of demand-side measures to limit warming to 1.5 °C, but it warns that not all of these options are “seen” or captured by current quantitative tools or progress indicators, and some remain insufficiently represented in the current policy discourse. Based on the set of papers presented in the special issue, we conclude that demand-side mitigation in line with the 1.5 °C goal is possible; however, it remains enormously challenging and dependent on both innovative technologies and policies, and behavioral change. Limiting warming to 1.5 °C requires, more than ever, a plurality of methods and integrated behavioral and technology approaches to better support policymaking and resulting policy interventions

Life cycle greenhouse gas emissions of blended cement concrete including carbonation and durability

The final publication is available at Springer via http://dx.doi.org/10.1007/s11367-013-0614-0Purpose Blended cements use waste products to replace Portland cement, the main contributor to CO2 emissions in concrete manufacture. Using blended cements reduces the embodied greenhouse gas emissions; however, little attention has been paid to the reduction in CO2 capture (carbonation) and durability. The aim of this study is to determine if the reduction in production emissions of blended cements compensates for the reduced durability and CO2 capture. Methods This study evaluates CO2 emissions and CO2 capture for a reinforced concrete column during its service life and after demolition and reuse as gravel filling material. Concrete depletion, due to carbonation and the unavoidable steel embedded corrosion, is studied, as this process consequently ends the concrete service life. Carbonation deepens progressively during service life and captures CO2 even after demolition due to the greater exposed surface area. In this study, results are presented as a function of cement replaced by fly ash (FA) and blast furnace slag (BFS). Results and discussion Concrete made with Portland cement, FA (35%FA), and BFS blended cements (80%BFS) captures 47, 41, and 20 % of CO2 emissions, respectively. The service life of blended cements with high amounts of cement replacement, like CEM III/A (50 % BFS), CEM III/B (80 % BFS), and CEMII/B-V (35%FA), was about 10%shorter, given the higher carbonation rate coefficient. Compared to Portland cement and despite the reduced CO2 capture and service life, CEM III/B emitted 20 % less CO2 per year. Conclusions To obtain reliable results in a life cycle assessment, it is crucial to consider carbonation during use and after demolition. Replacing Portland cement with FA, instead of BFS, leads to a lower material emission factor, since FA needs less processing after being collected, and transport distances are usually shorter. However, greater reductions were achieved using BFS, since a larger amount of cement can be replaced. Blended cements emit less CO2 per year during the life cycle of a structure, although a high cement replacement reduces the service life notably. If the demolished concrete is crushed and recycled as gravel filling material, carbonation can cut CO2 emissions by half. A case study is presented in this paper demonstrating how the results may be utilized.This research was financially supported by the Spanish Ministry of Science and Innovation (research project BIA2011-23602). The authors thank the anonymous reviewers for their constructive comments and useful suggestions. The authors are also grateful for the thorough revision of the manuscript by Dr. Debra Westall.García Segura, T.; Yepes Piqueras, V.; Alcalá González, J. (2014). Life cycle greenhouse gas emissions of blended cement concrete including carbonation and durability. International Journal of Life Cycle Assessment. 19(1):3-12. https://doi.org/10.1007/s11367-013-0614-0S312191Aïtcin PC (2000) Cements of yesterday and today: concrete of tomorrow. Cem Concr Res 30(9):1349–1359Angst U, Elsener B, Larsen C (2009) Critical chloride content in reinforced concrete—a review. Cement Concr Res 39(12):1122–1138Berge B (2000) The ecology of building materials. Architectural Press, OxfordBertolini L, Elsener B, Pedeferri P, Polder R (2004) Corrosion of Steel in Concrete—Prevention Diagnosis. Repair, Wiley-VCH, WeinheimBörjesson P, Gustavsson L (2000) Greenhouse gas balances in building construction: wood versus concrete from life cycle and forest land-use perspectives. 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Towards sustainable agriculture: fossil-free ammonia

Citation: Pfromm, P. H. (2017). Towards sustainable agriculture: Fossil-free ammonia. Journal of Renewable and Sustainable Energy, 9(3), 034702. https://doi.org/10.1063/1.4985090About 40% of our food would not exist without synthetic ammonia (NH3) for fertilization. Yet, NH3 production is energy intensive. About 2% of the world's commercial energy is consumed as fossil fuels for NH3 synthesis based on the century-old Haber-Bosch (H.-B.) process. The state of the art and the opportunities for reducing the fossil energy footprint of industrial H.-B. NH3 synthesis are discussed. It is shown that even a hypothetical utterly revolutionary H.-B. catalyst could not significantly reduce the energy demand of H.-B. NH3 as this is governed by hydrogen production. Renewable energy-enabled, fossil-free NH3 synthesis is then evaluated based on the exceptional and continuing cost decline of renewable electricity. H.-B. syngas (H2, N2) is assumed to be produced by electrolysis and cryogenic air separation, and then supplied to an existing H.-B. synthesis loop. Fossil-free NH3 could be produced for energy costs of about $232 per tonne NH3 without claiming any economic benefits for the avoidance of about 1.5 tonnes of CO2 released per tonne NH3 compared to the most efficient H.-B. implementations. Research into alternatives to the H.-B. process might be best targeted at emerging markets with currently little NH3 synthesis capacity but significant future population growth such as Africa. Reduced capital intensity, good scale-down economics, tolerance for process upsets and contamination, and intermittent operability are some desirable characteristics of NH3 synthesis in less developed markets, and for stranded resources. Processes that are fundamentally different from H.-B. may come to the fore under these specific boundary conditions

Multigroup Ethnic Identity Measure (MEIM) Expansion: Measuring Racial, Religious, and National Aspects of Sense of Ethnic Identity Within the United Kingdom

These studies examined the degree to which racial, religious, and national aspects of individuals' sense of ethnic identity stand as interrelated, yet distinct, constructs. Results of exploratory factor analyses in Study 1 (n = 272) revealed that a three-factor model specifying racial, religious, and national identities yielded optimal fit to correlational data from an expanded, 36-item version of the Multigroup Ethnic Identity Measure (MEIM; Roberts et al., 1999), although results left room for improvement in model fit. Subsequently, results of confirmatory factor analyses in Study 2 (n = 291) revealed that, after taking covariance among the items into account, a six-factor model specifying exploration and commitment dimensions within each of the racial, religious, and national identity constructs provided optimal fit. Implications for the utility of Goffman's (1963b) interactionist role theory and Erikson's (1968) ego psychology for understanding the full complexity of felt ethnic identity are discussed

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN