45 research outputs found
Percolation and cluster Monte Carlo dynamics for spin models
A general scheme for devising efficient cluster dynamics proposed in a
previous letter [Phys.Rev.Lett. 72, 1541 (1994)] is extensively discussed. In
particular the strong connection among equilibrium properties of clusters and
dynamic properties as the correlation time for magnetization is emphasized. The
general scheme is applied to a number of frustrated spin model and the results
discussed.Comment: 17 pages LaTeX + 16 figures; will appear in Phys. Rev.
On the link between rotation, chromospheric activity and Li abundance in subgiant stars
The connection rotation-CaII emission flux-lithium abundance is analyzed for
a sample of bona fide subgiant stars, with evolutionary status determined from
HIPPARCOS trigonometric parallax measurements and from the Toulouse-Geneva
code.Comment: 9 pages, 8 figure
Potential of Macrostomum lignano to recover from γ-ray irradiation
Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1Â month in a dose-dependent manner following exposure to up to 150Â Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210Â Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems
Fluoride inhibits the response of bone cells to mechanical loading
The response of bone cells to mechanical loading is mediated by the cytoskeleton. Since the bone anabolic agent fluoride disrupts the cytoskeleton, we investigated whether fluoride affects the response of bone cells to mechanical loading, and whether this is cytoskeleton mediated. The mechano-response of osteoblasts was assessed in vitro by measuring pulsating fluid flow-induced nitric oxide (NO) production. Osteocyte shape was determined in hamster mandibles in vivo as parameter of osteocyte mechanosensitivity. Pulsating fluid flow (0.7 ± 0.3 Pa, 5 Hz) stimulated NO production by 8-fold within 5 min. NaF (10-50 μM) inhibited pulsating fluid flow-stimulated NO production after 10 min, and decreased F-actin content by ~3-fold. Fluid flow-induced NO response was also inhibited after F-actin disruption by cytochalasin B. NaF treatment resulted in more elongated, smaller osteocytes in interdental bone in vivo. Our results suggest that fluoride inhibits the mechano-response of bone cells, which might occur via cytoskeletal changes. Since decreased mechanosensitivity reduces bone mass, the reported anabolic effect of fluoride on bone mass in vivo is likely mediated by other factors than changed bone cell mechanosensitivity. © 2011 The Society of The Nippon Dental University