The All Affected Interests Principle in Democratic Theory and Principle. IHS Political Science Series Working Paper No. 145, July 2017

The principle that all those affected by a collective decision should be included in the decision is long-standing, dating at least back to the Justinian Code (V,59,5,2) in Roman private law: “what touches all must be approved by all” (Quod omnes tangit debet ab omnibus approbari; see also Lane, this volume, for a history). Over the last several decades, the idea has migrated into democratic theory (Young 2000, chaps 1-2; Habermas 1996, 10511; Dahl 1970, 49-63, Benhabib 2004; cf. Fung 2013, Goodin 2007, Näsström 2011, Shapiro 2003, chap. 1). The reason, no doubt, is the principle expresses a very basic intuition about what democracy is good for: I should want to have a say in decisions that significantly affect my life. With say, I am part of networks of co-dependents who can collectively self-determine and provide opportunities for self-development while mitigating life-risks. Without it, I am likely to be subject to forces over which I have little or no control

Participatory Deliberative Democracy in Complex Mass Societies

What might participatory deliberative democracy look like in complex, mass societies? Cristina Lafont’s Democracy Without Shortcuts (2019) challenges us to revisit this question by taking contemporary democratic theory to task for recommending a variety of shortcuts that would seem to reconcile democratic self-government with complex, mass societies, but do so by requiring ‘blind deference’ of citizens to decisions made by others. Here I make three general points. First, democracy is possible in mass, complex societies just because democratic societies and governments are full of shortcuts, through representation, political, epistemic and advocacy divisions of labour, differentiated institutions, multi-level governance, and trust relationships both among citizens and between citizens and governments. Few of these shortcuts require ‘blind deference’ of citizens. Second, because complex societies are highly differentiated in their structures, they also multiply opportunities for participation in ways that Lafont does not theorise owing to a statist focus on constitutional, rights-based politics. But, third, in arguing against shortcuts, Lafont underscores the importance of assessing the many kinds of principal–agent relationships in complex mass societies to ensure they advance rather than undermine the norms of participatory deliberative democracy

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12)

It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes. In contrast to the aerobic pathway, the anaerobic route has remained enigmatic because many of its intermediates have proven technically challenging to isolate, because of their inherent instability. However, by studying the anaerobic cobalamin biosynthetic pathway in Bacillus megaterium and using homologously overproduced enzymes, it has been possible to isolate all of the intermediates between uroporphyrinogen III and cobyrinic acid. Consequently, it has been possible to detail the activities of purified cobinamide biosynthesis (Cbi) proteins CbiF, CbiG, CbiD, CbiJ, CbiET, and CbiC, as well as show the direct in vitro conversion of 5-aminolevulinic acid into cobyrinic acid using a mixture of 14 purified enzymes. This approach has resulted in the isolation of the long sought intermediates, cobalt-precorrin-6A and -6B and cobalt-precorrin-8. EPR, in particular, has proven an effective technique in following these transformations with the cobalt(II) paramagnetic electron in the dyz orbital, rather than the typical dz2. This result has allowed us to speculate that the metal ion plays an unexpected role in assisting the interconversion of pathway intermediates. By determining a function for all of the pathway enzymes, we complete the tool set for cobalamin biosynthesis and pave the way for not only enhancing cobalamin production, but also design of cobalamin derivatives through their combinatorial use and modification

Preliminary analysis of LDEF instrument A0187-1: Chemistry of Micrometeoroids Experiment

The Chemistry of Micrometeoroids Experiment (CME) exposed approximately 0.8 sq. m of gold on the Long Duration Exposure Facility's (LDEF's) trailing edge (location A03) and approximately 1.1 sq. m of aluminum in the forward-facing A11 location. The most significant results to date relate to the discovery of unmelted pyroxene and olivine fragments associated with natural cosmic dust impacts. The latter are sufficiently large for detailed phase studies, and they serve to demonstrate that recovery of unmelted dust fragments is a realistic prospect for further dust experiments that will employ more advanced collector media. We also discovered that man-made debris impacts occur on the LDEF's trailing edge with substantially higher frequency than expected, suggesting that orbital debris in highly elliptical orbits may have been somewhat underestimated

Cardiovascular Magnetic Resonance Imaging of Scar Development Following Pulmonary Vein Isolation: A Prospective Study

Aims Cardiovascular magnetic resonance (MR) provides non-invasive assessment of early (24-hour) edema and injury following pulmonary vein isolation (by ablation) and subsequent scar formation. We hypothesize that 24-hours after ablation, cardiovascular MR would demonstrate a pattern of edema and injury due to ablation and the severity would correlate with subsequent scar. Methods: Fifteen atrial fibrillation patients underwent cardiovascular MR prior to pulmonary vein isolation, 24-hours post (N = 11) and 30-days post (N = 7) ablation, with T2-weighted (T2W) and late gadolinium enhancement (LGE) imaging. Left atrial wall thickness, edema enhancement ratio and LGE enhancement were assessed at each time point. Volumes of LGE and edema enhancement were measured, and the circumferential presence of injury was assessed at 24-hours, including comparison with LGE enhancement at 30 days. Results: Left atrial wall thickness was increased 24-hours post-ablation (10.7±4.1 mm vs. 7.0±1.8 mm pre-PVI, p<0.05). T2W enhancement at 24-hours showed increased edema enhancement ratio (1.5±0.4 for post-ablation, vs. 0.9±0.2 pre-ablation, p<0.001). Edema and LGE volumes at 24-hours were correlated with 30-day LGE volume (R = 0.76, p = 0.04, and R = 0.74, p = 0.09, respectively). Using a 16 segment model for assessment, 24-hour T2W had sensitivity, specificity, and accuracy of 82%, 63%, and 79% respectively, for predicting 30-day LGE. 24-hour LGE had sensitivity, specificity, and accuracy of 91%, 47%, and 84%. Conclusions: Increased left atrial wall thickening and edema were characterized on cardiovascular MR early post-ablation, and found to correlate with 30-day LGE scar

Natural fracture patterns at Swift Reservoir anticline, NW Montana : the influence of structural position and lithology from multiple observation scales

Acknowledgements We gratefully acknowledge constructive reviews by Amerigo Corradetti and an anonymous reviewer and thank Stefano Tavani for editorial handling. Adam J. Cawood is grateful to David Ferrill, Kevin Smart, and Paul Gillespie for helpful conversations about fracture patterns, although the data and interpretations shown here are of course the sole responsibility of the authors. This study was carried out as part of a University of Aberdeen doctoral programme supported by the Natural Environment Research Council (NERC) Centre for Doctoral Training in Oil and Gas. Additional funding for fieldwork was provided by the University of Aberdeen Fold–Thrust Research Group. Petroleum Experts (formerly Midland Valley Exploration) is acknowledged for allowing the academic use of Move 2016.1 software. Financial support This research has been supported by the Natural Environment Research Council (grant no. NE/M00578X/1).Peer reviewedPublisher PD

Fracture distribution on the Swift Reservoir Anticline, Montana : implications for structural and lithological controls on fracture intensity

Title of special publication: Folding and Fracturing of Rocks: 50 Years of Research since the Seminal Text Book of J. G. Ramsay This research was funded by Oil Search Ltd, Santos Ltd and InterOil, through the University of Aberdeen Fold-Thrust Research Group. Electron Microscopy was performed in the ACEMAC Facility at the University of Aberdeen with assistance from John Still. Joyce Neilson is thanked for advice on the use of ImageJ software. Midland Valley are thanked for the use of their Move software for field data collection and model building. We thank Alfred Lacazette and Stefano Tavani for reviewing the manuscript and providing constructive comments.Peer reviewedPostprin