Challenging Official Propaganda? Public Opinion Leaders on Sina Weibo.

This article examines the prominence of various user categories as opinion leaders, defined as initiators, agenda setters or disseminators, in 29 corruption cases exposed on SinaWeibo. It finds that ordinary citizens made up the largest category of initiators but that their power of opinion leadership was limited as they had to rely on media organizations to spread news about the cases. News organizations and online media were the main opinion leaders. Government and Party bodies initiated a fair number of cases and, despite not being strong agenda setters or disseminators, were able to dominate public opinion owing to the fact that news organizations and online media mainly published official announcements about the cases. Media organizations also played a secondary role as the voice of the people. While individuals from some other user categories were able to become prominent opinion leaders, news workers are likely to be the most promising user category to challenge official propaganda.Faculty Research Support Scheme of the Faculty of Arts and Social Sciences, the University of Sydney. University of Hong Kong Seed Funding Program for Basic Research and the General Research Fund, Research Grants Council, Hong Kong (Project Code: 17402314)

The Dynamic Impacts of Employee Job Motivation on Employee Job Performance and Corporate Customer Satisfaction: The Contingent Role of ERP System Implementation

Prior research has generally found a significant, positive impact of employees\u27 job motivation on job performance, and which in turn, leads to more satisfied customers. However, little attention is directed towards how implementation of centralized information systems (IS), such as Enterprise Resource Planning (ERP) systems, will affect these relationships in the business to business (B2B) context. Toward this end, we plan to conduct a field study to empirically compare the effects of these relationships before and after the implementation of an ERP system. This cross-disciplinary study will contribute to the extant organization, marketing, and IS literature by examining how a centralized IS implementation moderates the relationships among employees’ job motivation, performance, and corporate customer satisfaction, and testing the proposed framework in the B2B context

Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.

The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malformations. Either maternal grandparent can initiate this phenomenon, which persists for at least four wildtype generations. Here, we use genome-wide approaches to reveal genetic stability in the Mtrr model and genome-wide differential DNA methylation in the germline of Mtrr mutant maternal grandfathers. We observe that, while epigenetic reprogramming occurs, wildtype grandprogeny and great grandprogeny exhibit transcriptional changes that correlate with germline methylation defects. One region encompasses the Hira gene, which is misexpressed in embryos for at least three wildtype generations in a manner that distinguishes Hira transcript expression as a biomarker of maternal phenotypic inheritance

Applications of Direct Injection Soft Chemical Ionisation-Mass Spectrometry for the Detection of Pre-blast Smokeless Powder Organic Additives

Analysis of smokeless powders is of interest from forensics and security perspectives. This article reports the detection of smokeless powder organic additives (in their pre-detonation condition), namely the stabiliser diphenylamine and its derivatives 2-nitrodiphenylamine and 4-nitrodiphenylamine, and the additives (used both as stabilisers and plasticisers) methyl centralite and ethyl centralite, by means of swab sampling followed by thermal desorption and direct injection soft chemical ionisation-mass spectrometry. Investigations on the product ions resulting from the reactions of the reagent ions H3O+ and O2+ with additives as a function of reduced electric field are reported. The method was comprehensively evaluated in terms of linearity, sensitivity and precision. For H3O+, the limits of detection (LoD) are in the range of 41-88 pg of additive, for which the accuracy varied between 1.5 and 3.2%, precision varied between 3.7 and 7.3% and linearity showed R20.9991. For O2+, LoD are in the range of 72 to 1.4 ng, with an accuracy of between 2.8 and 4.9% and a precision between 4.5 and 8.6% and R20.9914. The validated methodology was applied to the analysis of commercial pre-blast gun powders from different manufacturers.(VLID)4826148Accepted versio

Observation of anomalous decoherence effect in a quantum bath at room temperature

Decoherence of quantum objects is critical to modern quantum sciences and technologies. It is generally believed that stronger noises cause faster decoherence. Strikingly, recent theoretical research discovers the opposite case for spins in quantum baths. Here we report experimental observation of the anomalous decoherence effect for the electron spin-1 of a nitrogen-vacancy centre in high-purity diamond at room temperature. We demonstrate that under dynamical decoupling, the double-transition can have longer coherence time than the single-transition, even though the former couples to the nuclear spin bath as twice strongly as the latter does. The excellent agreement between the experimental and the theoretical results confirms the controllability of the weakly coupled nuclear spins in the bath, which is useful in quantum information processing and quantum metrology.Comment: 22 pages, related paper at http://arxiv.org/abs/1102.557

A network biology approach to prostate cancer

There is a need to identify genetic mediators of solid-tumor cancers, such as prostate cancer, where invasion and distant metastases determine the clinical outcome of the disease. Whole-genome expression profiling offers promise in this regard, but can be complicated by the challenge of identifying the genes affected by a condition from the hundreds to thousands of genes that exhibit changes in expression. Here, we show that reverse-engineered gene networks can be combined with expression profiles to compute the likelihood that genes and associated pathways are mediators of a disease. We apply our method to non-recurrent primary and metastatic prostate cancer data, and identify the androgen receptor gene (AR) among the top genetic mediators and the AR pathway as a highly enriched pathway for metastatic prostate cancer. These results were not obtained on the basis of expression change alone. We further demonstrate that the AR gene, in the context of the network, can be used as a marker to detect the aggressiveness of primary prostate cancers. This work shows that a network biology approach can be used advantageously to identify the genetic mediators and mediating pathways associated with a disease

When is universal SEL effective under authentic conditions? Using LPA to examine program implementation in elementary classrooms

As universal social-emotional learning (SEL) programs have become more common in K-12 schools, implementation practices have been found to affect program quality. However, research examining how multiple facets of program implementation interrelate and impact student outcomes, especially under routine conditions in schools, is still limited. As such, we used latent profile analysis (LPA) to examine implementation of a brief universal SEL program (Social Skills Improvement System SEL Classwide Intervention Program) in primary classrooms. Three latent profiles of implementation were identified based on dosage, adherence, quality of delivery, student engagement and teachers’ impression of lessons. Although results suggested that classrooms with moderate- and high-level implementation practices generally showed higher gains in student outcomes than those with low-level implementation, these differences did not reach statistical significance except for academic motivation. Implications for school-based universal SEL program planning, implementation, and evaluation are discussed

Waveguide Bandpass Filters for Millimeter-Wave Radiometers

A fundamental requirement for most mm-wave heterodyne receivers is the rejection of the input image signal which is located close to the local oscillator frequency. For this purpose we use a bandpass filter, which for heterodyne receivers is also called an image rejection filter. In this paper we present a systematic approach to the design of a waveguide bandpass filter with a passband from 100 to 110 GHz and upper rejection bandwidth in the range from 113 to 145 GHz. We consider two non-tunable filter configurations: the first one is relatively selective with 11 sections (poles) whereas the second one is simpler with 5 sections. We used established design equations to propose an initial guess for the geometries of the filters, optimized the geometries, constructed the filters using two different milling methods, measured their transmission and reflection characteristics, and compared the measurements with numerical simulations. Measurements of both filters agree well with simulations in frequency response and rejection bandwidth. The insertion loss of the 11-pole filter is better than 10 dB and that of the 5-pole filter is better than 5 dB. The 11-pole filter has a sharper attenuation roll-off compared with the 5-pole filter. The upper out-of-band rejection is better than 40 dB up to 145 GHz for the 11-pole filter and up to 155 GHz for the 5-pole filter

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.

The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas