Urgensi Pembatasan Masa periode Anggota Dewan Perwakilan Rakyat dalam Upaya Pencegahan Penyalahgunaan Kekuasaan

This paper aims to discuss the authority of members of the House of Representatives (DPR) in the 1945 Constitution of the Republic of Indonesia (UUDNRI 1945), the legal vacuum in determining the tenure of the DPR, and the urgency of ideal regulation DPR tenure. The study uses normative juridical research with a statutory and conceptual approach. The power of the DPR in the 1945 Constitution is very broad, not only relates to legislative power but also the executive and judicial. The regulation regarding the time limit for the DPR’s period has not yet been regulated (there is a legal vacuum). There is no statutory regulation governing the time limit for a person to become a member of the DPR. The urgency of limiting the period of members of the House of Representatives is to limit the holding of power too long and provide opportunities for other citizens. Members of the Regional House of Representative (DPRD) can serve for 2 periods at the district/city level, after which they can submit at the provincial level for 2 periods, and finally can apply to become a member of the DPR RI for 2 periods

Visual parameter optimisation for biomedical image processing

Background: Biomedical image processing methods require users to optimise input parameters to ensure high quality output. This presents two challenges. First, it is difficult to optimise multiple input parameters for multiple input images. Second, it is difficult to achieve an understanding of underlying algorithms, in particular, relationships between input and output. Results: We present a visualisation method that transforms users’ ability to understand algorithm behaviour by integrating input and output, and by supporting exploration of their relationships. We discuss its application to a colour deconvolution technique for stained histology images and show how it enabled a domain expert to identify suitable parameter values for the deconvolution of two types of images, and metrics to quantify deconvolution performance. It also enabled a breakthrough in understanding by invalidating an underlying assumption about the algorithm. Conclusions: The visualisation method presented here provides analysis capability for multiple inputs and outputs in biomedical image processing that is not supported by previous analysis software. The analysis supported by our method is not feasible with conventional trial-and-error approaches

Cytokine Production by Leukocytes of Military Personnel with Depressive Symptoms after Deployment to a Combat-Zone: A Prospective, Longitudinal Study

Major depressive disorder (MDD) is frequently diagnosed in military personnel returning from deployment. Literature suggests that MDD is associated with a pro-inflammatory state. To the best of our knowledge, no prospective, longitudinal studies on the association between development of depressive symptomatology and cytokine production by peripheral blood leukocytes have been published. The aim of this study was to investigate whether the presence of depressive symptomatology six months after military deployment is associated with the capacity to produce cytokines, as assessed before and after deployment. 1023 military personnel were included before deployment. Depressive symptoms and LPS- and T-cell mitogen-induced production of 16 cytokines and chemokines in whole blood cultures were measured before (T0), 1 (T1), and 6 (T2) months after return from deployment. Exploratory structural equation modeling (ESEM) was used for data reduction into cytokine patterns. Multiple group latent growth modeling was used to investigate differences in the longitudinal course of cytokine production between individuals with (n = 68) and without (n = 665) depressive symptoms at T2. Individuals with depressive symptoms after deployment showed higher T-cell cytokine production before deployment. Moreover, pre-deployment T-cell cytokine production significantly predicted the presence of depressive symptomatology 6 months after return. There was an increase in T-cell cytokine production over time, but this increase was significantly smaller in individuals developing depressive symptoms. T-cell chemokine and LPS-induced innate cytokine production decreased over time and were not associated with depressive symptoms. These results indicate that increased T-cell mitogen-induced cytokine production before deployment may be a vulnerability factor for development of depressive symptomatology in response to deployment to a combat-zone. In addition, deployment to a combat-zone affects the capacity of T-cells and monocytes to produce cytokines and chemokines until at least 6 months after return

Thalassemias in South Asia:clinical lessons learnt from Bangladesh

Abstract Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite the fact that Bangladesh lies in the world’s thalassemia belt, the information on different aspects (epidemiology, clinical course, mortality, complications and treatment outcomes) of thalassemias is lacking. In this comprehensive review, the aim is to to depict the epidemiological aspects of thalassemias, mutation profile and current treatment and management practices in the country by sharing the experience of dealing with 1178 cases over 2009–2014 time periods in a specialized thalassemia treatment centre. We have also discussed the preventative strategies of thalassemias from the context of Bangladesh which could be effective for other developing countries

Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

INTRODUCTION: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. METHODS: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. RESULTS: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-to-male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all-age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. DISCUSSION: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally

On the construction of metrics from fuzzy metrics and its application to the fixed point theory of multivalued mappings

[EN] We present a procedure to construct a compatible metric from a given fuzzy metric space. We use this approach to obtain a characterization of a large class of complete fuzzy metric spaces by means of a fuzzy version of Caristi’s fixed point theorem, obtaining, in this way, partial solutions to a recent question posed in the literature. Some illustrative examples are also given.The authors thank the referees for several useful suggestions. Salvador Romaguera and Pedro Tirado acknowledge the support of the Ministry of Economy and Competitiveness of Spain, grant MTM2012-37894-C02-01.Castro Company, F.; Romaguera Bonilla, S.; Tirado Peláez, P. (2015). On the construction of metrics from fuzzy metrics and its application to the fixed point theory of multivalued mappings. Fixed Point Theory and Applications. 2015:226. https://doi.org/10.1186/s13663-015-0476-1S2015:226Kelley, JL: General Topology. Springer, New York (1955)Schweizer, B, Sklar, A: Statistical metric spaces. Pac. J. Math. 10, 314-334 (1960)Klement, E, Mesiar, R, Pap, E: Triangular Norms. Kluwer Academic, Dordrecht (2000)Hamacher, H: Über logische Verknüpfungen unscharfer Aussagen und deren zugehörige Bewertungsfunktionen. In: Progress in Cybernetics and Systems Research, pp. 276-287. Hemisphere, New York (1975)Kramosil, I, Michalek, J: Fuzzy metrics and statistical metric spaces. Kybernetika 11, 326-334 (1975)George, A, Veeramani, P: On some results in fuzzy metric spaces. Fuzzy Sets Syst. 64, 395-399 (1994)Gregori, V, Romaguera, S: Some properties of fuzzy metric spaces. Fuzzy Sets Syst. 115, 485-489 (2000)Radu, V: On the triangle inequality in PM-spaces. STPA, West University of Timişoara 39 (1978)Abbas, M, Ali, B, Romaguera, S: Multivalued Caristi’s type mappings in fuzzy metric spaces and a characterization of fuzzy metric completeness. Filomat 29(6), 1217-1222 (2015)Cho, YJ, Grabiec, M, Radu, V: On Nonsymmetric Topological and Probabilistic Structures. Nova Science Publishers, New York (2006)Hadžić, O, Pap, E: Fixed Point Theory in Probabilistic Metric Spaces. Kluwer Academic, Dordrecht (2001)Mihet, D: A note on Hicks type contractions on generalized Menger spaces. STPA, West University of Timişoara 133 (2002)Mihet, D: A Banach contraction theorem in fuzzy metric spaces. Fuzzy Sets Syst. 144, 431-439 (2004)Radu, V: Some fixed point theorems in PM spaces. In: Stability Problems for Stochastic Models. Lecture Notes in Mathematics, vol. 1233, pp. 125-133. Springer, Berlin (1985)Radu, V: Some remarks on the probabilistic contractions on fuzzy Menger spaces (The Eighth Intern. Conf. on Applied Mathematics and Computer Science, Cluj-Napoca, 2001). Autom. Comput. Appl. Math. 11(1), 125-131 (2002)Chauhan, S, Shatanawi, W, Kumar, S, Radenović, S: Existence and uniqueness of fixed points in modified intuitionistic fuzzy metric spaces. J. Nonlinear Sci. Appl. 7, 28-41 (2014)Hussain, N, Salimi, P, Parvaneh, V: Fixed point results for various contractions in parametric and fuzzy b-metric spaces. J. Nonlinear Sci. Appl. 8, 719-739 (2015)Mihet, D: Common coupled fixed point theorems for contractive mappings in fuzzy metric spaces. J. Nonlinear Sci. Appl. 6, 35-40 (2013)Hicks, TL: Fixed point theory in probabilistic metric spaces. Zb. Rad. Prir.-Mat. Fak. (Novi Sad) 13, 63-72 (1983)Radu, V: Some suitable metrics on fuzzy metric spaces. Fixed Point Theory 5, 323-347 (2004)O’Regan, D, Saadati, R: Nonlinear contraction theorems in probabilistic spaces. Appl. Math. Comput. 195, 86-93 (2008)Caristi, J: Fixed point theorems for mappings satisfying inwardness conditions. Trans. Am. Math. Soc. 215, 241-251 (1976)Kirk, WA: Caristi’s fixed-point theorem and metric convexity. Colloq. Math. 36, 81-86 (1976)Ansari, QH: Metric Spaces: Including Fixed Point Theory and Set-Valued Maps. Alpha Science, Oxford (2010

Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature

Libman-Sacks endocarditis of the mitral valve was first described by Libman and Sacks in 1924. Currently, the sterile verrucous vegetative lesions seen in Libman-Sacks endocarditis are regarded as a cardiac manifestation of both systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asymptomatic, complications of Libman-Sacks endocarditis may include superimposed bacterial endocarditis, thromboembolic events, and severe valvular regurgitation and/or stenosis requiring surgery. In this study we report two cases of mitral valve repair and two cases of mitral valve replacement for mitral regurgitation (MR) caused by Libman-Sacks endocarditis. In addition, we provide a systematic review of the English literature on mitral valve surgery for MR caused by Libman-Sacks endocarditis. This report shows that mitral valve repair is feasible and effective in young patients with relatively stable SLE and/or APS and only localized mitral valve abnormalities caused by Libman-Sacks endocarditis. Both clinical and echocardiographic follow-up after repair show excellent mid- and long-term results

The importance of organizational characteristics for improving outcomes in patients with chronic disease: a systematic review of congestive heart failure

Luci K. Leykum, Jacqueline Pugh, Valerie Lawrence, and Polly H. Noel are with the South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio TX, 78229, USA -- Michael Parchman is with the South Texas Veterans Health Care System and Department of Family and Community Medicine, University of Texas Health Science Center at San Antonio, San Antonio TX, 78229, USA -- Reuben R. McDaniel Jr. is with the McComb's School of Business, University of Texas at Austin, Austin TX, USABackground: Despite applications of models of care and organizational or system-level interventions to improve patient outcomes for chronic disease, consistent improvements have not been achieved. This may reflect a mismatch between the interventions and the nature of the settings in which they are attempted. The application of complex adaptive systems (CAS) framework to understand clinical systems and inform efforts to improve them may lead to more successful interventions. We performed a systematic review of interventions to improve outcomes of patients with congestive heart failure (CHF) to examine whether interventions consistent with CAS are more likely to be effective. We then examine differences between interventions that are most effective for improving outcomes for patients with CHF versus previously published data for type 2 diabetes to explore the potential impact of the nature of the disease on the types of interventions that are more likely to be effective. Methods: We conducted a systematic review of the literature between 1998 and 2008 of organizational interventions to improve care of patients with CHF. Two independent reviewers independently assessed studies that met inclusion criteria to determine whether each reported intervention reflected one or more CAS characteristics. The effectiveness of interventions was rated as either 0 (no effect), 0.5 (mixed effect), or 1.0 (effective) based on the type, number, and significance of reported outcomes. Fisher's exact test was used to examine the association between CAS characteristics and intervention effectiveness. Specific CAS characteristics associated with intervention effectiveness for CHF were contrasted with previously published data for type 2 diabetes. Results and discussion: Forty-four studies describing 46 interventions met eligibility criteria. All interventions utilized at least one CAS characteristic, and 85% were either 'mixed effect' or 'effective' in terms of outcomes. The number of CAS characteristics present in each intervention was associated with effectiveness (p < 0.001), supporting the idea that interventions consistent with CAS are more likely to be effective. The individual CAS characteristics associated with CHF intervention effectiveness were learning, self-organization, and co-evolution, a finding different from our previously published analysis of interventions for diabetes. We suggest this difference may be related to the degree of uncertainty involved in caring for patients with diabetes versus CHF. Conclusion: These results suggest that for interventions to be effective, they must be consistent with the CAS nature of clinical systems. The difference in specific CAS characteristics associated with intervention effectiveness for CHF and diabetes suggests that interventions must also take into account attributes of the disease.McCombs School of [email protected]