462 research outputs found
La naturaleza como símbolo del camino espiritual: la poesía de Qi-Ji y de San Juan de la Cruz
Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma
Recent studies indicated nm23-H1 played a role in cancer progression. Therefore, we investigated clinical significance of nm23-H1 expression in oral squamous cell carcinoma (OSCC). In total, 86 OSCC specimens were immunohistochemically stained with nm23-H1-specific monoclonal antibodies. Immunohistochemical staining of nm23-H1 was confirmed by immunoblotting. The relations between nm23-H1 expression and clinicopathologic variables were evaluated by chi(2) analysis. As increased size of primary tumour could escalate metastatic potential and the data of patients at the late T stage might confound statistical analyses, we thus paid special attention to 54 patients at the early T stage of OSCC. Statistical difference of survival was compared by a log-rank test. Immunohistochemically, nm23-H1 expression was detected in 48.8% (42 out of 86) of tumorous specimens. It positively correlated with larger primary tumour size (P = 0.03) and inversely with cigarette-smoking habit (P = 0.042). In patients at the early T stage, decreased nm23 expression was associated with increased incidence of lymph node metastasis (P = 0.004) and indicated poor survival (P = 0.014). Tumour nm23-H1 expression is a prognostic factor for predicting better survival in OSCC patients at the early T stage, which may reflect antimetastatic potential of nm23. Therefore, modulation of nm23-H1 expression in cancer cells can provide a novel possibility of improving therapeutic strategy at this stage. In addition, our results further indicated cigarette smoking could aggravate the extent of nm23-H1 expression and possibly disease progression of OSCC patients. (C) 2004 Cancer Research UK
Equivariant cohomology and analytic descriptions of ring isomorphisms
In this paper we consider a class of connected closed -manifolds with a
non-empty finite fixed point set, each of which is totally non-homologous
to zero in (or -equivariantly formal), where . With the
help of the equivariant index, we give an explicit description of the
equivariant cohomology of such a -manifold in terms of algebra, so that we
can obtain analytic descriptions of ring isomorphisms among equivariant
cohomology rings of such -manifolds, and a necessary and sufficient
condition that the equivariant cohomology rings of such two -manifolds are
isomorphic. This also leads us to analyze how many there are equivariant
cohomology rings up to isomorphism for such -manifolds in 2- and
3-dimensional cases.Comment: 20 pages, updated version with two references adde
Oscillating magnetoresistance in diluted magnetic semiconductor barrier structures
Ballistic spin polarized transport through diluted magnetic semiconductor
(DMS) single and double barrier structures is investigated theoretically using
a two-component model. The tunneling magnetoresistance (TMR) of the system
exhibits oscillating behavior when the magnetic field are varied. An
interesting beat pattern in the TMR and spin polarization is found for
different NMS/DMS double barrier structures which arises from an interplay
between the spin-up and spin-down electron channels which are splitted by the
s-d exchange interaction.Comment: 4 pages, 6 figures, submitted to Phys. Rev.
Association of Chinese Herbal Medicine use with the depression risk among the long-term breast cancer survivors: A longitudinal follow-up study
Background Breast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation(CHM) into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors. Methods A cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at least1 year after diagnosis. After one-to-one matching for age, sex, and baseline comorbidities, breast cancer patients who received (n = 1,450) and did not receive (n = 1,450) CHM treatment were enrolled. The incidence rate and hazard ratio citation(HR) for depression between the two groups was estimated at the end of 2012. A Cox proportional hazard model was constructed to examine the impact of the CHM use on the risk of depression. Results During the study period, the incidence rate of depression was significantly lower in the treated cohort than in the untreated cohort [8.57 compared with 11.01 per 1,000 person-years citation(PYs)], and the adjusted HR remained significant at 0.74 (95% CI 0.58–0.94) in a Cox proportional hazards regression model. The corresponding risk further decreasing to 43% among those using CHM for more than 1 year. Conclusion Finding from this investigation indicated that the lower risk of depression observed in breast cancer patients treated with CHM, suggesting that CHM treatment should be considered for disease management toward breast cancer. Yet, the optimal administered dose should be determined in further clinical trials
Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy
Background: Non-small cell lung cancer (NSCLC) patients with L858R or exon 19 deletion mutations in epidermal growth factor receptor (EGFR) have good responses to the tyrosine kinase inhibitor (TKI), gefitinib. However, patients with wild-type EGFR and acquired mutation in EGFR T790M are resistant to gefitinib treatment. Here, we showed that curcumin can improve the efficiency of gefitinib in the resistant NSCLC cells both in vitro and in vivo models. Methods/Principal Findings: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. In addition, the antitumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP. Interestingly, we observed that the combined treatment group represented better survival rate and less intestinal mucosal damage compare to gefitinib-alone therapy. We showed that curcumin attenuated the gefitinib-induced cell proliferation inhibition and apoptosis through altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell. Conclusions/Significance: Curcumin potentiates antitumor activity of gefitinib in cell lines and xenograft mice model of NSCLC through inhibition of proliferation, EGFR phosphorylation, and induction EGFR ubiquitination and apoptosis. In addition, curcumin attenuates gefitinib-induced gastrointestinal adverse effects via altering p38 activation. These findings provide a novel treatment strategy that curcumin as an adjuvant to increase the spectrum of the usage of gefitinib and overcome the gefitinib inefficiency in NSCLC patients
New lanostanes and naphthoquinones isolated from Antrodia salmonea and their antioxidative burst activity in human leukocytes
Four new compounds were isolated from the basidiomata of the fungus Antrodia salmonea, a newly identified species of Antrodia (Aphyllophorales) in Taiwan. These new compounds are named as lanosta-8,24-diene-3 beta,15 alpha,21-triol (1), 24-methylenelanost-8-ene-3 beta,15 alpha,21-triol (2), 2,3-dimethoxy-5-(2',5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (3), and 2,3-dimethoxy-6-(2,5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (4), respectively. Their structures were elucidated by spectroscopic methods. An in vitro cellular functional assay was performed to evaluate their anti-oxidative burst activity in human leukocytes. They showed inhibitory effects against phorbol 12-myristate-13-acetate (PMA), a direct protein kinase C activator, induced oxidative burst in neutrophils (PMN) and mononuclear cells (MNC) with 50% inhibitory concentration (IC50) ranging from 3.5 to 25.8 mu M. The potency order of these compounds in PMA-activated leukocytes was as 1 > 3 > 4 > 2. They were relatively less effective in formyl-Met-Leu-Phe (fMLP), a G-protein coupled receptor agonist, induced oxidative burst, except for compounds 3 and 4 in fMLP-activated PMN. These results indicated that three (1, 3, and 4) of these four newly identified compounds displayed antioxidative effect in human leukocytes with different potency and might confer anti-inflammatory activity to these drugs
Dynamical properties of the unitary Fermi gas: collective modes and shock waves
We discuss the unitary Fermi gas made of dilute and ultracold atoms with an
infinite s-wave inter-atomic scattering length. First we introduce an efficient
Thomas-Fermi-von Weizsacker density functional which describes accurately
various static properties of the unitary Fermi gas trapped by an external
potential. Then, the sound velocity and the collective frequencies of
oscillations in a harmonic trap are derived from extended superfluid
hydrodynamic equations which are the Euler-Lagrange equations of a
Thomas-Fermi-von Weizsacker action functional. Finally, we show that this
amazing Fermi gas supports supersonic and subsonic shock waves.Comment: 9 pages, 3 figures, invited talk at the International Workshop
"Critical Stability 2011" (Erice, October 2011), to be published in the
journal Few Body System
Quantum Interference in Superconducting Wire Networks and Josephson Junction Arrays: Analytical Approach based on Multiple-Loop Aharonov-Bohm Feynman Path-Integrals
We investigate analytically and numerically the mean-field
superconducting-normal phase boundaries of two-dimensional superconducting wire
networks and Josephson junction arrays immersed in a transverse magnetic field.
The geometries we consider include square, honeycomb, triangular, and kagome'
lattices. Our approach is based on an analytical study of multiple-loop
Aharonov-Bohm effects: the quantum interference between different electron
closed paths where each one of them encloses a net magnetic flux. Specifically,
we compute exactly the sums of magnetic phase factors, i.e., the lattice path
integrals, on all closed lattice paths of different lengths. A very large
number, e.g., up to for the square lattice, exact lattice path
integrals are obtained. Analytic results of these lattice path integrals then
enable us to obtain the resistive transition temperature as a continuous
function of the field. In particular, we can analyze measurable effects on the
superconducting transition temperature, , as a function of the magnetic
filed , originating from electron trajectories over loops of various
lengths. In addition to systematically deriving previously observed features,
and understanding the physical origin of the dips in as a result of
multiple-loop quantum interference effects, we also find novel results. In
particular, we explicitly derive the self-similarity in the phase diagram of
square networks. Our approach allows us to analyze the complex structure
present in the phase boundaries from the viewpoint of quantum interference
effects due to the electron motion on the underlying lattices.Comment: 18 PRB-type pages, plus 8 large figure
The Yuan-Tseh Lee Array for Microwave Background Anisotropy
The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is the
first interferometer dedicated to studying the cosmic microwave background
(CMB) radiation at 3mm wavelength. The choice of 3mm was made to minimize the
contributions from foreground synchrotron radiation and Galactic dust emission.
The initial configuration of seven 0.6m telescopes mounted on a 6-m hexapod
platform was dedicated in October 2006 on Mauna Loa, Hawaii. Scientific
operations began with the detection of a number of clusters of galaxies via the
thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak lensing
data in order to study the structure of dark matter. We also compare our data
with X-ray data in order to derive the Hubble constant.Comment: accepted for publication in ApJ (13 pages, 7 figures); a version with
high resolution figures available at
http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/pho_highreso.pd
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