34 research outputs found

    Comparative analysis of the genes UL1 through UL7 of the duck enteritis virus and other herpesviruses of the subfamily Alphaherpesvirinae

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    The nucleotide sequences of eight open reading frames (ORFs) located at the 5' end of the unique long region of the duck enteritis virus (DEV) Clone-03 strain were determined. The genes identified were designated UL1, UL2, UL3, UL4, UL5, UL6 and UL7 homologues of the herpes simplex virus 1 (HSV-1). The DEV UL3.5 located between UL3 and UL4 had no homologue in the HSV-1. The arrangement and transcription orientation of the eight genes were collinear with their homologues in the HSV-1. Phylogenetic trees were constructed based on the alignments of the deduced amino acids of eight proteins with their homologues in 12 alpha-herpesviruses. In the UL1, UL3, UL3.5, UL5 and UL7 proteins trees, the branches were more closely related to the genus Mardivirus. However, the UL2, UL4, and UL6 proteins phylogenetic trees indicated a large distance from Mardivirus, indicating that the DEV evolved differently from other viruses in the subfamily Alphaherpesvirinae and formed a single branch within this subfamily

    5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

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    Geodynamic of the SouthWest Pacific: a brief review and relations to New Caledonia geology

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    The SW Pacific region consists of a succession of ridges and basins that were created by the fragmentation of Gondwana and the evolution of subduction zones since Mesozoic times. This complex geodynamic evolution shaped the geology of New Caledonia, which lies in the northern part of the Zealandia continent. Alternative tectonic models have been postulated. Most models agree that New Caledonia was situated on an active plate margin of eastern Gondwana during the Mesozoic. Extension affected the region from the Late Cretaceous to the Paleocene and models for this period vary in the location and nature of the plate boundary between the Pacific and Australian plates. Eocene regional tectonic contraction included the obduction of a mantle-derived Peridotite Nappe in New Caledonia. In one class of model, this contractional phase was controlled by an east-dipping subduction zone into which the Norfolk Ridge jammed, whereas and in a second class of model this phase corresponds to the initiation of the west-dipping Tonga–Kermadec subduction zone. Neogene tectonics of the region near New Caledonia was dominated by the eastwards retreat of Tonga–Kermadec subduction, leading to the opening of a back-arc basin east of New Caledonia, and the initiation and southwestwards advance of the New Hebrides–Vanuatu subduction zone towards New Caledonia
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