The Kiln and Red Earthenware Pottery of the Jordan Pottery Site: A Preliminary Overview

No abstract is available at this time

Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi"

The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function. In addition to the complete knock-out by homologous recombination, several different techniques have been developed to temporarily knock down gene expression through methods based on specific sequence recognition, such as knockdown by antisense oligonucleotides, ribozymes, aptamers or RNAi. The ESF workshop on ‘Impact of Nucleic Acid Chemistry on Gene Function Analysis’ brought together researchers who use techniques that are different but highly related. It offered an opportunity for an in-depth discussion of recent progress and common problems. Antisense oligonucleotides aptamers and ribozymes are techniques that have been used successfully for many years to validate targets. However, recent developments, such as increased tightness of binding (e.g. locked nucleic acids) or the combination of different methods (e.g. using aptamers to design ribozymes), have continued to improve the existing techniques. RNA interference (RNAi) is a defence mechanism of the cell against viruses. Since the exact mechanism of action within the cell is still unclear, RNAi was a particularly exciting topic at the workshop and was addressed in the largest number of presentations. Predictability of positional effects (accessibility of RNA) is a problem shared by all techniques using sequence-specific recognition and was the subject of quite controversial debates. The meeting comprised over 50 people from 14 countries (13 European countries and the USA)

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative fluctuations in bulk histone modifications during development. To investigate this issue we analysed histones isolated from four different developmental stages of Xenopus laevis by mass spectrometry. In toto, we quantified 59 modification states on core histones H3 and H4 from blastula to tadpole stages. During this developmental period, we observed in general an increase in the unmodified states, and a shift from histone modifications associated with transcriptional activity to transcriptionally repressive histone marks. We also compared these naturally occurring patterns with the histone modifications of murine ES cells, detecting large differences in the methylation patterns of histone H3 lysines 27 and 36 between pluripotent ES cells and pluripotent cells from Xenopus blastulae. By combining all detected modification transitions we could cluster their patterns according to their embryonic origin, defining specific histone modification profiles (HMPs) for each developmental stage. To our knowledge, this data set represents the first compendium of covalent histone modifications and their quantitative flux during normogenesis in a vertebrate model organism. The HMPs indicate a stepwise maturation of the embryonic epigenome, which may be causal to the progressing restriction of cellular potency during development

Machine Learning for Quantum Mechanical Properties of Atoms in Molecules

We introduce machine learning models of quantum mechanical observables of atoms in molecules. Instant out-of-sample predictions for proton and carbon nuclear chemical shifts, atomic core level excitations, and forces on atoms reach accuracies on par with density functional theory reference. Locality is exploited within non-linear regression via local atom-centered coordinate systems. The approach is validated on a diverse set of 9k small organic molecules. Linear scaling of computational cost in system size is demonstrated for saturated polymers with up to sub-mesoscale lengths

Fuzzy Line Bundles, the Chern Character and Topological Charges over the Fuzzy Sphere

Using the theory of quantized equivariant vector bundles over compact coadjoint orbits we determine the Chern characters of all noncommutative line bundles over the fuzzy sphere with regard to its derivation based differential calculus. The associated Chern numbers (topological charges) arise to be non-integer, in the commutative limit the well known integer Chern numbers of the complex line bundles over the 2-sphere are recovered.Comment: Latex2e, 13 pages, 1 figure. This paper continues and supersedes math-ph/0103003. v2: Typos correcte

NASA Docking System Block 1: NASA's New Direct Electric Docking System Supporting ISS and Future Human Space Exploration

The NASA Docking System (NDS) Block 1 is a key component of NASA's vision for space exploration. It is designed to provide capability for visiting vehicles to dock to the International Space Station's recently-installed International Docking Adapter ports. It is the first docking system to be developed by NASA since the Apollo-Soyuz Test Project of the 1970's. The NDS Block 1 includes provisions for capture, structural attachment, power/data transfer, and undocking. It uses a direct-drive electromechanical Stewart Platform capture system architecture, along with an innovative automated control scheme, to achieve an unprecedented level of performance and simplicity. Its design implements the new International Docking System Standard, which will be a key enabler of diverse and flexible exploration missions in future iterations. NDS qualification was completed in 2017 to support a planned first flight in 2018 on the Boeing CST-100 Starliner

Relativistic Contributions to Deuteron Photodisintegration in the Bethe-Salpeter Formalism

In plane wave one-body approximation the reaction of deuteron photodisintegration is considered in the framework of the Bethe-Salpeter formalism for two-nucleon system. Results are obtained for deuteron vertex function, which is the solution of the homogeneous Bethe-Salpeter equation with a multi-rank separable interaction kernel, with a given analytical form. A comparison is presented with predictions of non-relativistic, quasipotential approaches and the equal time approximation. It is shown that important contributions come from the boost in the arguments of the initial state vertex function and the boost on the relative energy in the one-particle propagator due to recoil.Comment: 29 pages, 6 figure

Centennial Celebration Chimes

Photographs of large groups of people with the photo of a man inset among them.https://scholarsjunction.msstate.edu/cht-sheet-music/2983/thumbnail.jp

Linear Actuator System for the NASA Docking System

The Linear Actuator System (LAS) is a major sub-system within the NASA Docking System (NDS). The NDS Block 1 will be used on the Boeing Crew Space Transportation (CST-100) system to achieve docking with the International Space Station. Critical functions in the Soft Capture aspect of docking are performed by the LAS. This paper describes the general function of the LAS, the system's key requirements and technical challenges, and the development and qualification approach for the system