Flux emergence and coronal eruption

Our aim is to study the photospheric flux distribution of a twisted flux tube that emerges from the solar interior. We also report on the eruption of a new flux rope when the emerging tube rises into a pre-existing magnetic field in the corona. To study the evolution, we use 3D numerical simulations by solving the time-dependent and resistive MHD equations. We qualitatively compare our numerical results with MDI magnetograms of emerging flux at the solar surface. We find that the photospheric magnetic flux distribution consists of two regions of opposite polarities and elongated magnetic tails on the two sides of the polarity inversion line (PIL), depending on the azimuthal nature of the emerging field lines and the initial field strength of the rising tube. Their shape is progressively deformed due to plasma motions towards the PIL. Our results are in qualitative agreement with observational studies of magnetic flux emergence in active regions (ARs). Moreover, if the initial twist of the emerging tube is small, the photospheric magnetic field develops an undulating shape and does not possess tails. In all cases, we find that a new flux rope is formed above the original axis of the emerging tube that may erupt into the corona, depending on the strength of the ambient field.Comment: 5 pages, 3 figures, accepted for publication in A&

Vitamin K status and physical decline in older adults—The Longitudinal Aging Study Amsterdam

Objective: We examined the association between vitamin K status and physical functioning over 13 years in the Longitudinal Aging Study Amsterdam. Study design: Longitudinal cohort study of 633 community-dwelling adults from the Longitudinal Aging Study Amsterdam (LASA) aged 55–65 years (54% women). Main outcome measures: At baseline (2002–2003), plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured with a sandwich ELISA as a marker of vitamin K status. The outcome measures handgrip strength, calf circumference, self-reported functional limitations and functional performance were obtained at baseline and four follow-up examinations. We used generalized estimating equations to determine the relationship between dp-ucMGP tertiles and the various outcome measurements after adjusting for potential confounders. The lowest dp-ucMGP tertile reflects a high vitamin K status and was the reference. Results: Mean dp-ucMGP was 376 ± 233 pmol/L and mean follow-up was 11.1 years. Participants showed a decline in the outcome measures over time. Compared with the lowest tertile, the highest dp-ucMGP tertile had: lower handgrip strength, 1.1 kg (95% confidence interval (−2.1, −0.1; P-trend <0.001); smaller calf circumference, −0.5 cm (−0.9 −0.1; P-trend = 0.018); and, only among women, a 0.7-point poorer functional performance score (−1.1, −0.3; P-interaction = 0.002). Dp-ucMGP was not related to self-reported functional limitations. No interaction effects between time and dp-ucMGP were observed. Conclusions: Low vitamin K status was associated with lower handgrip strength, smaller calf circumference, and, in women only, with poorer functional performance score. A low vitamin K status was however not related to the 13-year decline in these measures

Unravelling transmission trees of infectious diseases by combining genetic and epidemiological data

Knowledge on the transmission tree of an epidemic can provide valuable insights into disease dynamics. The transmission tree can be reconstructed by analysing either detailed epidemiological data (e.g. contact tracing) or, if sufficient genetic diversity accumulates over the course of the epidemic, genetic data of the pathogen. We present a likelihood-based framework to integrate these two data types, estimating probabilities of infection by taking weighted averages over the set of possible transmission trees. We test the approach by applying it to temporal, geographical and genetic data on the 241 poultry farms infected in an epidemic of avian influenza A (H7N7) in The Netherlands in 2003. We show that the combined approach estimates the transmission tree with higher correctness and resolution than analyses based on genetic or epidemiological data alone. Furthermore, the estimated tree reveals the relative infectiousness of farms of different types and sizes. (Résumé d'auteur

The Three-dimensional Evolution of Rising, Twisted Magnetic Flux Tubes in a Gravitationally Stratified Model Convection Zone

We present three-dimensional numerical simulations of the rise and fragmentation of twisted, initially horizontal magnetic flux tubes which evolve into emerging Omega-loops. The flux tubes rise buoyantly through an adiabatically stratified plasma that represents the solar convection zone. The MHD equations are solved in the anelastic approximation, and the results are compared with studies of flux tube fragmentation in two dimensions. We find that if the initial amount of field line twist is below a critical value, the degree of fragmentation at the apex of a rising Omega-loop depends on its three-dimensional geometry: the greater the apex curvature of a given Omega-loop, the lesser the degree of fragmentation of the loop as it approaches the photosphere. Thus, the amount of initial twist necessary for the loop to retain its cohesion can be reduced substantially from the two-dimensional limit. The simulations also suggest that as a fragmented flux tube emerges through a relatively quiet portion of the solar disk, extended crescent-shaped magnetic features of opposite polarity should form and steadily recede from one another. These features eventually coalesce after the fragmented portion of the Omega-loop emerges through the photosphere.Comment: 17 pages, 17 figures, uses AAS LaTeX macros v5.0. ApJ, in pres

The Hydromagnetic Interior of a Solar Quiescent Prominence. I. Coupling between Force-balance and Steady Energy-transport

This series of papers investigates the dynamic interior of a quiescent prominence revealed by recent {\it Hinode} and {\it SDO/AIA} high-resolution observations. This first paper is a study of the static equilibrium of the Kippenhahn-Schl\"{u}ter diffuse plasma slab, suspended vertically in a bowed magnetic field, under the frozen-in condition and subject to a theoretical thermal balance among an optically-thin radiation, heating, and field-aligned thermal conduction. The everywhere-analytical solutions to this nonlinear problem are an extremely restricted subset of the physically admissible states of the system. For most values of the total mass frozen into a given bowed field, force-balance and steady energy-transport cannot both be met without a finite fraction of the total mass having collapsed into a cold sheet of zero thickness, within which the frozen-in condition must break down. An exact, resistive hydromagnetic extension of the Kippenhahn-Schl\"{u}ter slab is also presented, resolving the mass-sheet singularity into a finite-thickness layer of steadily-falling dense fluid. Our hydromagnetic result suggests that the narrow, vertical prominence $H_{\alpha}$ threads may be falling across magnetic fields, with optically-thick cores much denser and ionized to much lower degrees than conventionally considered. This implication is discussed in relation to (i) the recent {\it SDO/AIA} observations of quiescent prominences that are massive and yet draining mass everywhere in their interiors, (ii) the canonical range of $5-60 G$ determined from spectral-polarimetric observations of prominence magnetic fields over the years and (iii) the need for a more realistic multi-fluid treatment.Comment: 45 pages, 14 figure

Reversal Of Arterial Disease by modulating Magnesium and Phosphate (ROADMAP-study):rationale and design of a randomized controlled trial assessing the effects of magnesium citrate supplementation and phosphate-binding therapy on arterial stiffness in moderate chronic kidney disease

Background: Arterial stiffness and calcification propensity are associated with high cardiovascular risk and increased mortality in chronic kidney disease (CKD). Both magnesium and phosphate are recognized as modulators of vascular calcification and chronic inflammation, both features of CKD that contribute to arterial stiffness. In this paper, we outline the rationale and design of a randomized controlled trial (RCT) investigating whether 24 weeks of oral magnesium supplementation with or without additional phosphate-binding therapy can improve arterial stiffness and calcification propensity in patients with stage 3-4 CKD. Methods: In this multi-center, placebo-controlled RCT, a total of 180 participants with an estimated glomerular filtration rate of 15 to 50 ml/min/1.73 m(2) without phosphate binder therapy will be recruited. During the 24 weeks intervention, participants will be randomized to one of four intervention groups to receive either magnesium citrate (350 mg elemental magnesium/day) or placebo, with or without the addition of the phosphate binder sucroferric oxyhydroxide (1000 mg/day). Primary outcome of the study is the change of arterial stiffness measured by the carotid-femoral pulse wave velocity over 24 weeks. Secondary outcomes include markers of calcification and inflammation, among others calcification propensity (T-50) and high-sensitivity C-reactive protein. As explorative endpoints, repeated F-18-FDG and F-18-NaF PET-scans will be performed in a subset of participants (n = 40). Measurements of primary and secondary endpoints are performed at baseline, 12 and 24 weeks. Discussion: The combined intervention of magnesium citrate supplementation and phosphate-lowering therapy with sucroferric oxyhydroxide, in stage 3-4 CKD patients without overt hyperphosphatemia, aims to modulate the complex and deregulated mineral metabolism leading to vascular calcification and arterial stiffness and to establish to what extent this is mediated by T(50 )changes. The results of this combined intervention may contribute to future early interventions for CKD patients to reduce the risk of CVD and mortality