Feedback control of unstable cellular solidification fronts

We present a numerical and experimental study of feedback control of unstable cellular patterns in directional solidification (DS). The sample, a dilute binary alloy, solidifies in a 2D geometry under a control scheme which applies local heating close to the cell tips which protrude ahead of the other. For the experiments, we use a real-time image processing algorithm to track cell tips, coupled with a movable laser spot array device, to heat locally. We show, numerically and experimentally, that spacings well below the threshold for a period-doubling instability can be stabilized. As predicted by the numerical calculations, cellular arrays become stable, and the spacing becomes uniform through feedback control which is maintained with minimal heating.Comment: 4 pages, 4 figures, 1 tabl

Resolution of Linear Algebra for the Discrete Logarithm Problem Using GPU and Multi-core Architectures

In cryptanalysis, solving the discrete logarithm problem (DLP) is key to assessing the security of many public-key cryptosystems. The index-calculus methods, that attack the DLP in multiplicative subgroups of finite fields, require solving large sparse systems of linear equations modulo large primes. This article deals with how we can run this computation on GPU- and multi-core-based clusters, featuring InfiniBand networking. More specifically, we present the sparse linear algebra algorithms that are proposed in the literature, in particular the block Wiedemann algorithm. We discuss the parallelization of the central matrix--vector product operation from both algorithmic and practical points of view, and illustrate how our approach has contributed to the recent record-sized DLP computation in GF($2^{809}$).Comment: Euro-Par 2014 Parallel Processing, Aug 2014, Porto, Portugal. \<http://europar2014.dcc.fc.up.pt/\&gt

The effect of network topology on the stability of discrete state models of genetic control

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed uncorrelated random network structure. Real gene networks typically have nontrivial topology significantly different from the random network paradigm. In order to address such situations, we present a general method for determining the stability of large Boolean networks of any specified network topology and predicting their steady-state behavior in response to small perturbations. Additionally, we generalize to the case where individual genes have a distribution of `expression biases,' and we consider non-synchronous update, as well as extension of our method to non-Boolean models in which there are more than two possible gene states. We find that stability is governed by the maximum eigenvalue of a modified adjacency matrix, and we test this result by comparison with numerical simulations. We also discuss the possible application of our work to experimentally inferred gene networks.Comment: 25 pages, 4 figures; added supplementary information, fixed typos and figure, reformatte

From Radio to X-ray: Flares on the dMe Flare Star EV Lacertae

We present the results of a campaign to observe flares on the M dwarf flare star EV Lacertae over the course of two days in 2001 September, utilizing a combination of radio continuum, optical photometric and spectroscopic, ultraviolet spectroscopic, and X-ray spectroscopic observations, to characterize the multi-wavelength nature of flares from this active, single late-type star. We find flares in every wavelength region in which we observed. In the multi-wavelength context, the start of the intense radio flare is coincident with an impulsive optical U-band flare, to within one minute, and yet there is no signature of an X-ray response. There are other intervals of time where optical flaring and UV flaring is occurring, but these cannot be related to the contemporaneous X-ray flaring: the time-integrated luminosities do not match the instantaneous X-ray flare luminosity, as one would expect for the Neupert effect. We investigate the probability of chance occurrences of flares from disparate wavelength regions producing temporal coincidences, but find that not all the flare associations can be explained by a superposition of flares due to a high flaring rate. We caution against making causal associations of multi-wavelength flares based solely on temporal correlations for high flaring rate stars like EV Lac.Comment: 52 pages, 13 figures, accepted for publication in the Astrophysical Journa

On the shortness of vectors to be found by the Ideal-SVP quantum algorithm

The hardness of finding short vectors in ideals of cyclotomic number fields (hereafter, Ideal-SVP) can serve as a worst-case assumption for numerous efficient cryptosystems, via the average-case problems Ring-SIS and Ring-LWE. For a while, it could be assumed the Ideal-SVP problem was as hard a

Integration of the β-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2

THE COMPLEXITY OF WNT SIGNALING LIKELY STEMS FROM TWO SOURCES: multiple pathways emanating from frizzled receptors in response to wnt binding, and modulation of those pathways and target gene responsiveness by context-dependent signals downstream of growth factor and matrix receptors. Both rac1 and c-jun have recently been implicated in wnt signaling, however their upstream activators have not been identified.Here we identify the adapter protein Grb2, which is itself an integrator of multiple signaling pathways, as a modifier of beta-catenin-dependent wnt signaling. Grb2 synergizes with wnt3A, constitutively active (CA) LRP6, Dvl2 or CA-beta-catenin to drive a LEF/TCF-responsive reporter, and dominant negative (DN) Grb2 or siRNA to Grb2 block wnt3A-mediated reporter activity. MMP9 is a target of beta-catenin-dependent wnt signaling, and an MMP9 promoter reporter is also responsive to signals downstream of Grb2. Both a jnk inhibitor and DN-c-jun block transcriptional activation downstream of Dvl2 and Grb2, as does DN-rac1. Integrin ligation by collagen also synergizes with wnt signaling as does overexpression of Focal Adhesion Kinase (FAK), and this is blocked by DN-Grb2.These data suggest that integrin ligation and FAK activation synergize with wnt signaling through a Grb2-rac-jnk-c-jun pathway, providing a context-dependent mechanism for modulation of wnt signaling