199 research outputs found
Development of a hydrogen-oxygen internal combustion engine space power system
Hydrogen-oxygen internal combustion engine space power syste
Taxation and Market Power
We analyze the incidence and welfare e¤ects of unit sales taxes in experimental monopoly and Bertrand markets. We nd, in line with economic theory, that rms with no market power are able to shift a high share of a tax burden on to consumers, independent of whether buyers are automated or human players. In monopoly markets, a monopolist bears a large share of the burden of a tax increase. With human buyers, however, this share is smaller than with automated buyers as the presence of human buyers constrains the pricing behavior of a monopolist.tax incidence;monopoly;Bertrand competition;experiment
Development of a hydrogen-oxygen space power supply system
Hydrogen oxygen engine and component design and failure repor
Development of a hydrogen-oxygen space power supply system Progress report, 1-30 Nov. 1963
Hydrogen-oxygen space power supply syste
Development of a hydrogen-oxygen space power supply system Progress report, Jul. 1-31, 1963
Development of auxiliary electric power generation system for hydrogen-oxygen spacecraft - redesign of oxygen injector and first stage cylinder hea
Taxation and Market Power
We analyze the incidence and welfare e¤ects of unit sales taxes in experimental monopoly and Bertrand markets. We nd, in line with economic theory, that rms with no market power are able to shift a high share of a tax burden on to consumers, independent of whether buyers are automated or human players. In monopoly markets, a monopolist bears a large share of the burden of a tax increase. With human buyers, however, this share is smaller than with automated buyers as the presence of human buyers constrains the pricing behavior of a monopolist.
Fluorocarbon seal replaces metal piston ring in low density gas environment
Reinforced fluorocarbon cupseal, which provides an integral lip-type seal, replaces the metal piston rings in piston-cylinder configurations used in the compression of low density gases. The fluorocarbon seal may be used as cryogenic compressor piston seals
Charmonium-hadron interactions from QCD
The heavy quark system is an excellent probe to learn about the QCD dynamics
at finite density. First, we discuss the properties of the and
meson at finite nucleon density. We discuss why their properties should change
at finite density and then introduce an exact QCD relation among these hadron
properties and the energy momentum tensor of the medium. Second, we discuss
attempts to calculate charmonium-hadron total cross section using effective
hadronic models and perturbative QCD. We emphasize a recent calculation, where
the cross section is derived using QCD factorization theorem. We conclude by
discussing some challenges for SIS 200.Comment: 8 pages, Presented at 6th International Conference on Strange Quarks
in Matter: 2001: A Flavorspace Odyssey (SQM2001), Frankfurt, Germany, 25-29
Sep 2001, submitted to J. Phys.
Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor
T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials. The anti-CD3ε antibody UCHT1 enhanced the in vitro tumor killing activity of human γδ T cells by an unknown molecular mechanism. Here, we demonstrate that Fab fragments of UCHT1, which only bind monovalently to the γδ TCR, also enhanced tumor killing by expanded human Vγ9Vδ2 γδ T cells or pan-γδ T cells of the peripheral blood. The Fab fragments induced Nck recruitment to the γδ TCR, suggesting that they stabilized the γδ TCR in an active CD3ε conformation. However, blocking the Nck-CD3ε interaction in γδ T cells using the small molecule inhibitor AX-024 neither reduced the γδ T cells' natural nor the Fab-enhanced tumor killing activity. Likewise, Nck recruitment to CD3ε was not required for intracellular signaling, CD69 and CD25 up-regulation, or cytokine secretion by γδ T cells. Thus, the Nck-CD3ε interaction seems to be dispensable in γδ T cells
Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor
T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials. The anti-CD3ε antibody UCHT1 enhanced the in vitro tumor killing activity of human γδ T cells by an unknown molecular mechanism. Here, we demonstrate that Fab fragments of UCHT1, which only bind monovalently to the γδ TCR, also enhanced tumor killing by expanded human Vγ9Vδ2 γδ T cells or pan-γδ T cells of the peripheral blood. The Fab fragments induced Nck recruitment to the γδ TCR, suggesting that they stabilized the γδ TCR in an active CD3ε conformation. However, blocking the Nck-CD3ε interaction in γδ T cells using the small molecule inhibitor AX-024 neither reduced the γδ T cells’ natural nor the Fab-enhanced tumor killing activity. Likewise, Nck recruitment to CD3ε was not required for intracellular signaling, CD69 and CD25 up-regulation, or cytokine secretion by γδ T cells. Thus, the Nck-CD3ε interaction seems to be dispensable in γδ T cells
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