1,516 research outputs found
Theory and experiment of entanglement in a quasi-phase-matched two-crystal source
We report new results regarding a source of polarization entangled
photon-pairs created by the process of spontaneous parametric downconversion in
two orthogonally oriented, periodically poled, bulk KTiOPO4 crystals (PPKTP).
The source emits light colinearly at the non-degenerate wavelengths of 810 nm
and 1550 nm, and is optimized for single-mode optical fiber collection and
long-distance quantum communication. The configuration favors long crystals,
which promote a high photon-pair production rate at a narrow bandwidth,
together with a high pair-probability in fibers. The quality of entanglement is
limited by chromatic dispersion, which we analyze by determining the output
state. We find that such a decoherence effect is strongly material dependent,
providing for long crystals an upper bound on the visibility of the coincidence
fringes of 41% for KTiOPO4, and zero for LiNbO3. The best obtained raw
visibility, when canceling decoherence with an extra piece of crystal, was 91
\pm 0.2%, including background counts. We confirm by a violation of the
CHSH-inequality (S = 2.679 \pm 0.004 at 55 s^{-1/2} standard deviations) and by
complete quantum state tomography that the fibers carry high-quality entangled
pairs at a maximum rate of 55 x 10^3 s^{-1}THz^{-1}mW^{-1}.Comment: 12 pages, 10 figures, REVTeX
Semisimplicity of the quantum cohomology for smooth Fano toric varieties associated with facet symmetric polytopes
The degree zero part of the quantum cohomology algebra of a smooth Fano toric
symplectic manifold is determined by the superpotential function, W, of its
moment polytope. In particular, this algebra is semisimple, i.e. splits as a
product of fields, if and only if all the critical points of W are
non-degenerate. In this paper we prove that this non-degeneracy holds for all
smooth Fano toric varieties with facet-symmetric duals to moment polytopes.Comment: 16 pages; corrected version, published in Electron. Res. Announc.
Math. Sc
A high-brightness source of polarization-entangled photons optimized for applications in free space
We present a simple but highly efficient source of polarization-entangled
photons based on spontaneous parametric down-conversion (SPDC) in bulk
periodically poled potassium titanyl phosphate crystals (PPKTP) pumped by a 405
nm laser diode. Utilizing one of the highest available nonlinear coefficients
in a non-degenerate, collinear type-0 phase-matching configuration, we generate
polarization entanglement via the crossed-crystal scheme and detect 0.64
million photon pair events/s/mW, while maintaining an overlap fidelity with the
ideal Bell state of 0.98 at a pump power of 0.025 mW
Highly Efficient Source for Indistinguishable Photons of Controlled Shape
We demonstrate a straightforward implementation of a push-button like
single-photon source which is based on a strongly coupled atom-cavity system.
The device operates intermittently for periods of up to 100 microseconds, with
single-photon repetition rates of 1.0 MHz and an efficiency of 60 %. Atoms are
loaded into the cavity using an atomic fountain, with the upper turning point
near the cavity's mode centre. This ensures long interaction times without any
disturbances induced by trapping potentials. The latter is the key to reaching
deterministic efficiencies as high as obtained in probabalistic
photon-heralding schemes. The price to pay is the random loading of atoms into
the cavity and the resulting intermittency. However, for all practical
purposes, this has a negligible impact
UV-induced ligand exchange in MHC class I protein crystals
High-throughput structure determination of protein−ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy. Crystals of a protein complex bound to a photosensitive ligand are exposed to UV light, inducing the departure of the bound ligand, allowing a new ligand to soak in. We exemplify the approach for a class of protein complexes that is especially recalcitrant to high-throughput strategies: the MHC class I proteins. We developed a UV-sensitive, “conditional”, peptide ligand whose UV-induced cleavage in the crystals leads to the exchange of the low-affinity lytic fragments for full-length peptides introduced in the crystallant solution. This “in crystallo” exchange is monitored by the loss of seleno-methionine anomalous diffraction signal of the conditional peptide compared to the signal of labeled MHC β2m subunit. This method has the potential to facilitate high-throughput crystallography in various protein families
The Palomar Testbed Interferometer Calibrator Catalog
The Palomar Testbed Interferometer (PTI) archive of observations between 1998
and 2005 is examined for objects appropriate for calibration of optical
long-baseline interferometer observations - stars that are predictably
point-like and single. Approximately 1,400 nights of data on 1,800 objects were
examined for this investigation. We compare those observations to an
intensively studied object that is a suitable calibrator, HD217014, and
statistically compare each candidate calibrator to that object by computing
both a Mahalanobis distance and a Principal Component Analysis. Our hypothesis
is that the frequency distribution of visibility data associated with
calibrator stars differs from non-calibrator stars such as binary stars.
Spectroscopic binaries resolved by PTI, objects known to be unsuitable for
calibrator use, are similarly tested to establish detection limits of this
approach. From this investigation, we find more than 350 observed stars
suitable for use as calibrators (with an additional being
rejected), corresponding to sky coverage for PTI. This approach
is noteworthy in that it rigorously establishes calibration sources through a
traceable, empirical methodology, leveraging the predictions of spectral energy
distribution modeling but also verifying it with the rich body of PTI's on-sky
observations.Comment: 100 pages, 7 figures, 7 tables; to appear in the May 2008ApJS, v176n
Class I major histocompatibility complexes loaded by a periodate trigger
Class I major histocompatibility complexes (MHCs) present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. The unstable nature of unliganded MHC necessitates the production of recombinant class I complexes through in vitro refolding reactions in the presence of an added excess of peptides. This strategy is not amenable to high-throughput production of vast collections of class I complexes. To address this issue, we recently designed photocaged MHC ligands that can be cleaved by a UV light trigger in the MHC bound state under conditions that do not affect the integrity of the MHC structure. The results obtained with photocaged MHC ligands demonstrate that conditional MHC ligands can form a generally applicable concept for the creation of defined peptide−MHCs. However, the use of UV exposure to mediate ligand exchange is unsuited for a number of applications, due to the lack of UV penetration through cell culture systems and due to the transfer of heat upon UV irradiation, which can induce evaporation. To overcome these limitations, here, we provide proof-of-concept for the generation of defined peptide−MHCs by chemical trigger-induced ligand exchange. The crystal structure of the MHC with the novel chemosensitive ligand showcases that the ligand occupies the expected binding site, in a conformation where the hydroxyl groups should be reactive to periodate. We proceed to validate this technology by producing peptide−MHCs that can be used for T cell detection. The methodology that we describe here should allow loading of MHCs with defined peptides in cell culture devices, thereby permitting antigen-specific T cell expansion and purification for cell therapy. In addition, this technology will be useful to develop miniaturized assay systems for performing high-throughput screens for natural and unnatural MHC ligands
Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials.
BACKGROUND: Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has been largely unknown, and this systematic review was aimed at assessing their short-term efficacies for pain relief. METHODS: Systematic review with meta-analysis of efficacy within 1-4 weeks and at follow up at 1-12 weeks after the end of treatment. RESULTS: 36 randomised placebo-controlled trials (RCTs) were identified with 2434 patients where 1391 patients received active treatment. 33 trials satisfied three or more out of five methodological criteria (Jadad scale). The patient sample had a mean age of 65.1 years and mean baseline pain of 62.9 mm on a 100 mm visual analogue scale (VAS). Within 4 weeks of the commencement of treatment manual acupuncture, static magnets and ultrasound therapies did not offer statistically significant short-term pain relief over placebo. Pulsed electromagnetic fields offered a small reduction in pain of 6.9 mm [95% CI: 2.2 to 11.6] (n = 487). Transcutaneous electrical nerve stimulation (TENS, including interferential currents), electro-acupuncture (EA) and low level laser therapy (LLLT) offered clinically relevant pain relieving effects of 18.8 mm [95% CI: 9.6 to 28.1] (n = 414), 21.9 mm [95% CI: 17.3 to 26.5] (n = 73) and 17.7 mm [95% CI: 8.1 to 27.3] (n = 343) on VAS respectively versus placebo control. In a subgroup analysis of trials with assumed optimal doses, short-term efficacy increased to 22.2 mm [95% CI: 18.1 to 26.3] for TENS, and 24.2 mm [95% CI: 17.3 to 31.3] for LLLT on VAS. Follow-up data up to 12 weeks were sparse, but positive effects seemed to persist for at least 4 weeks after the course of LLLT, EA and TENS treatment was stopped. CONCLUSION: TENS, EA and LLLT administered with optimal doses in an intensive 2-4 week treatment regimen, seem to offer clinically relevant short-term pain relief for OAK
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