Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine – a review

Purpose The impact on patients’ health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE. NET (www.peddose.net), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals. Methods A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (www.ncbi.nlm.nih.gov/pubmed). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting. Results Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago. Conclusion It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained

Untersuchung der Ganzkoerperverteilung nach Myokardszintigraphie mit Thallium-201

SIGLETIB Hannover: DR 3662 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Bezuege von Politikern: Eine Dokumentation

Bibliothek Weltwirtschaft Kiel C 140597 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Abbau und Ersatz der Gewerbesteuer Darstellung, Kritik, Vorschlaege

Bibliothek Weltwirtschaft Kiel A150,822 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Zur Konsolidierung der Bundesanstalt fuer Arbeit

SIGLEBibliothek Weltwirtschaft Kiel A142,270 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Monitoring treatment outcome: A visualization prototype for left ventricular transformation

The analysis of cardiac dynamics - especially of the left ventricle - is a means for evaluating the healthiness of the heart. In case that a malfunction has been detected and afterwards has been treated, the question arises whether the treatment was successful or not. On a longer time scale, it is of clinical interest to compare the results of follow-up studies with those of former examinations. In this paper, we address both issues by presenting a visualization prototype for the comparison of left ventricular dynamics obtained from cine-MRI data. Our approach is based on the computation of differences for standard cardiac parameters between two time series which have been acquired prior to and after treatment. For their visualization, we use a series of bull's-eye displays allowing for an in-depth examination of the treatment outcome. Here, we focus on the special clinical application ventricular reduction surgery where we perform a retrospective evaluation for cine-MRI data acquired prior to and right after surgery as well as several months later. We compare our results with diagnosis information obtained from clinical experts